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    Mthfd2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 680308, updated on 9-Dec-2024

    Summary

    Official Symbol
    Mthfd2provided by RGD
    Official Full Name
    methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolaseprovided by RGD
    Primary source
    RGD:1311313
    See related
    EnsemblRapid:ENSRNOG00000010833 AllianceGenome:RGD:1311313
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including magnesium ion binding activity; methenyltetrahydrofolate cyclohydrolase activity; and methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity. Predicted to be involved in tetrahydrofolate interconversion. Predicted to be active in mitochondrion. Biomarker of hepatocellular carcinoma. Orthologous to human MTHFD2 (methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 961.6), Thymus (RPKM 265.8) and 2 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Mthfd2 in Genome Data Viewer
    Location:
    4q34
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (117368833..117380350, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (115811135..115822663, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (115004433..115015965, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene WD repeat domain 54 Neighboring gene dynactin subunit 1 Neighboring gene solute carrier family 4 member 5 Neighboring gene uncharacterized LOC134486596 Neighboring gene uncharacterized LOC134486597 Neighboring gene MOB kinase activator 1A Neighboring gene bolA family member 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables methenyltetrahydrofolate cyclohydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables methenyltetrahydrofolate cyclohydrolase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables methylenetetrahydrofolate dehydrogenase (NAD+) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables methylenetetrahydrofolate dehydrogenase (NAD+) activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables methylenetetrahydrofolate dehydrogenase (NADP+) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables methylenetetrahydrofolate dehydrogenase (NADP+) activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphate ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
     
    involved_in tetrahydrofolate interconversion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in tetrahydrofolate metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial
    Names
    methylenetetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase
    methylenetetrahydrofolate dehydrogenase 2
    NP_001102868.1
    XP_038964266.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109398.1NP_001102868.1  bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial

      See identical proteins and their annotated locations for NP_001102868.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473957
      UniProtKB/TrEMBL
      A6IAL8, D4A1Y5
      Related
      ENSRNOP00000014603.7, ENSRNOT00000014603.7
      Conserved Domains (1) summary
      COG0190
      Location:38332
      FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      117368833..117380350 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039108338.2XP_038964266.1  bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial isoform X1

      UniProtKB/TrEMBL
      A0A8I6GID3, D4A1Y5
      Related
      ENSRNOP00000089768.1, ENSRNOT00000103961.2
      Conserved Domains (1) summary
      COG0190
      Location:38376
      FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]