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    Lmf1 lipase maturation factor 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360495, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Lmf1provided by RGD
    Official Full Name
    lipase maturation factor 1provided by RGD
    Primary source
    RGD:1310180
    See related
    EnsemblRapid:ENSRNOG00000000230 AllianceGenome:RGD:1310180
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1310180
    Summary
    Predicted to be involved in protein maturation and triglyceride metabolic process. Predicted to act upstream of or within several processes, including chylomicron remnant clearance; positive regulation of lipoprotein lipase activity; and regulation of lipid metabolic process. Predicted to be active in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in familial lipase maturation factor 1 deficiency. Orthologous to human LMF1 (lipase maturation factor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 68.3), Liver (RPKM 61.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Lmf1 in Genome Data Viewer
    Location:
    10q12
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (15094432..15188665)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (14597726..14684071)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (14945185..15031855)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120095051 Neighboring gene SRY-box transcription factor 8 Neighboring gene uncharacterized LOC120095315 Neighboring gene chromosome transmission fidelity factor 18 Neighboring gene G protein subunit gamma 13

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Lipase maturation factor 1: its expression in Zucker diabetic rats, and effects of metformin and fenofibrate. Forcheron F, et al. Diabetes Metab, 2009 Dec. PMID 19854668
    2. Differential effect of combined lipase deficiency (cld/cld) on human hepatic lipase and lipoprotein lipase secretion. Boedeker JC, et al. J Lipid Res, 2001 Nov. PMID 11714855
    3. Brefeldin A enables synthesis of active lipoprotein lipase in cld/cld and castanospermine-treated mouse brown adipocytes via translocation of Golgi components to endoplasmic reticulum. Park JW, et al. Biochem J, 1996 Jul 1. PMID 8694753, Free PMC Article
    4. Combined lipase deficiency (cld/cld) in mice. Demonstration that an inactive form of lipoprotein lipase is synthesized. Olivecrona T, et al. J Biol Chem, 1985 Feb 25. PMID 3972797
    5. Combined lipase deficiency in the mouse. Evidence of impaired lipase processing and secretion. Davis RC, et al. J Biol Chem, 1990 Oct 15. PMID 2211673

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    acts_upstream_of_or_within chylomicron remnant clearance ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within endoplasmic reticulum to Golgi vesicle-mediated transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of lipoprotein lipase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein glycosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein maturation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein maturation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein secretion ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of cholesterol metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of triglyceride metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in triglyceride metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    lipase maturation factor 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427222.1 → NP_001414151.1  lipase maturation factor 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      D3ZF16
      Related
      ENSRNOP00000000246.8, ENSRNOT00000000246.9

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      15094432..15188665
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063269313.1 → XP_063125383.1  lipase maturation factor 1 isoform X1

    2. XM_063269312.1 → XP_063125382.1  lipase maturation factor 1 isoform X1

    3. XM_039087107.2 → XP_038943035.1  lipase maturation factor 1 isoform X2

      Conserved Domains (1) summary
      pfam06762
      Location:1 → 312
      LMF1; Lipase maturation factor

    4. XM_039087108.2 → XP_038943036.1  lipase maturation factor 1 isoform X3

      Conserved Domains (1) summary
      pfam06762
      Location:2 → 299
      LMF1; Lipase maturation factor

    5. XM_063269314.1 → XP_063125384.1  lipase maturation factor 1 isoform X4

    RNA

    1. XR_010055201.1 RNA Sequence

    2. XR_010055202.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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