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    Rhot2 ras homolog family member T2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 287156, updated on 14-Nov-2024

    Summary

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    Official Symbol
    Rhot2provided by RGD
    Official Full Name
    ras homolog family member T2provided by RGD
    Primary source
    RGD:727970
    See related
    EnsemblRapid:ENSRNOG00000019930 AllianceGenome:RGD:727970
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Miro2
    Summary
    Predicted to enable GTP binding activity and GTPase activity. Predicted to be involved in cellular homeostasis; mitochondrial outer membrane permeabilization; and mitochondrion transport along microtubule. Predicted to be located in mitochondrion. Predicted to be active in mitochondrial outer membrane. Orthologous to human RHOT2 (ras homolog family member T2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Heart (RPKM 137.3), Kidney (RPKM 132.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rhot2 in Genome Data Viewer
    Location:
    10q12
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (15363467..15369263, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (14858954..14864751, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (15205943..15211739, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene jumonji domain containing 8 Neighboring gene STIP1 homology and U-box containing protein 1 Neighboring gene rhomboid like 1 Neighboring gene WD repeat domain 90 Neighboring gene MAPK regulated co-repressor interacting protein 2 Neighboring gene methyltransferase like 26 Neighboring gene transfer RNA glycine (anticodon CCC) 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Bidirectional Ca2+-dependent control of mitochondrial dynamics by the Miro GTPase. Saotome M, et al. Proc Natl Acad Sci U S A, 2008 Dec 30. PMID 19098100, Free PMC Article
    2. Atypical Rho GTPases have roles in mitochondrial homeostasis and apoptosis. Fransson A, et al. J Biol Chem, 2003 Feb 21. PMID 12482879
    3. The atypical Rho GTPases Miro-1 and Miro-2 have essential roles in mitochondrial trafficking. Fransson S, et al. Biochem Biophys Res Commun, 2006 Jun 2. PMID 16630562
    4. Cloning and characterization of the mouse Arht2 gene which encodes a putative atypical GTPase. Shan Y, et al. Cytogenet Genome Res, 2004. PMID 15218247
    5. Regulation of mitochondrial transport in neurons. Lin MY, et al. Exp Cell Res, 2015 May 15. PMID 25612908, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in cellular homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in mitochondrial outer membrane permeabilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrial outer membrane permeabilization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in mitochondrion organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrion transport along microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrion transport along microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrion transport along microtubule ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial outer membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial outer membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial outer membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    mitochondrial Rho GTPase 2
    Names
    MIRO-2
    ras homolog gene family, member T2
    NP_861544.1
    XP_017452558.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_181823.1 → NP_861544.1  mitochondrial Rho GTPase 2

      See identical proteins and their annotated locations for NP_861544.1

      Status: PROVISIONAL

      Source sequence(s)
      AY303973
      UniProtKB/Swiss-Prot
      Q7TSA0
      UniProtKB/TrEMBL
      A6HD65
      Conserved Domains (6) summary
      smart00174
      Location:7 → 169
      RHO; Rho (Ras homology) subfamily of Ras-like small GTPases
      cd01892
      Location:414 → 593
      Miro2; Mitochondrial Rho family 2 (Miro2), C-terminal
      cd01893
      Location:3 → 169
      Miro1; Mitochondrial Rho family 1 (Miro1), N-terminal
      COG1100
      Location:422 → 534
      Gem1; GTPase SAR1 family domain [General function prediction only]
      pfam08355
      Location:341 → 408
      EF_assoc_1; EF hand associated
      pfam08356
      Location:221 → 301
      EF_assoc_2; EF hand associated

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      15363467..15369263 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017597069.2 → XP_017452558.1  mitochondrial Rho GTPase 2 isoform X1

      UniProtKB/Swiss-Prot
      Q7TSA0
      UniProtKB/TrEMBL
      A6HD65
      Related
      ENSRNOP00000027083.3, ENSRNOT00000027083.7
      Conserved Domains (6) summary
      smart00174
      Location:7 → 169
      RHO; Rho (Ras homology) subfamily of Ras-like small GTPases
      cd01892
      Location:414 → 593
      Miro2; Mitochondrial Rho family 2 (Miro2), C-terminal
      cd01893
      Location:3 → 169
      Miro1; Mitochondrial Rho family 1 (Miro1), N-terminal
      COG1100
      Location:422 → 534
      Gem1; GTPase SAR1 family domain [General function prediction only]
      pfam08355
      Location:341 → 408
      EF_assoc_1; EF hand associated
      pfam08356
      Location:221 → 301
      EF_assoc_2; EF hand associated
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7TSA0.1 GenPept UniProtKB/Swiss-Prot:Q7TSA0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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