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    Rtkn rhotekin [ Rattus norvegicus (Norway rat) ]

    Gene ID: 297383, updated on 3-Dec-2024

    Summary

    Symbol
    Rtknprovided by RGD
    Full Name
    rhotekinprovided by RGD
    Primary source
    RGD:727874
    See related
    EnsemblRapid:ENSRNOG00000009022 AllianceGenome:RGD:727874
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable GTPase inhibitor activity and small GTPase binding activity. Predicted to be involved in several processes, including Rho protein signal transduction; cytoskeleton-dependent cytokinesis; and septin ring organization. Predicted to be active in actomyosin contractile ring. Orthologous to human RTKN (rhotekin). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 67.7), Kidney (RPKM 44.4) and 8 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Rtkn in Genome Data Viewer
    Location:
    4q34
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (117198496..117215660)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (115640813..115657952)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (114833453..114850705)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene WW domain binding protein 1 Neighboring gene INO80 complex subunit B Neighboring gene uncharacterized LOC108350719 Neighboring gene WD repeat domain 54 Neighboring gene similar to human chromosome 2 open reading frame 81 Neighboring gene dynactin subunit 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables GTPase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GTPase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables GTPase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables GTPase inhibitor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables small GTPase binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in Rho protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in Rho protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in Rho protein signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in actomyosin contractile ring assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mitotic cytokinesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in septin ring organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in actomyosin contractile ring IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001415851.2NP_001402780.1  rhotekin isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/Swiss-Prot
      Q6V7V1, Q6V7V2
      UniProtKB/TrEMBL
      A0A8I6G5K4, A6IAK9
      Related
      ENSRNOP00000032233.3, ENSRNOT00000031964.6
    2. NM_001415852.2NP_001402781.1  rhotekin isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A0A8I6AIK7, A0A8I6G5K4
      Related
      ENSRNOP00000092765.1, ENSRNOT00000101909.2
    3. NM_001415853.2NP_001402782.1  rhotekin isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A0A8I6G5K4
      Related
      ENSRNOP00000099265.1, ENSRNOT00000124729.1
    4. NM_001415854.2NP_001402783.1  rhotekin isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
    5. NM_184046.3NP_908935.1  rhotekin isoform 1

      See identical proteins and their annotated locations for NP_908935.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/Swiss-Prot
      Q6V7V1, Q6V7V2
      UniProtKB/TrEMBL
      A0A8I6G5K4, A6IAK9
      Conserved Domains (3) summary
      smart00742
      Location:2378
      Hr1; Rho effector or protein kinase C-related kinase homology region 1 homologues
      pfam08174
      Location:104257
      Anillin; Cell division protein anillin
      cl17171
      Location:296406
      PH-like; Pleckstrin homology-like domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      117198496..117215660
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063285792.1XP_063141862.1  rhotekin isoform X5

      UniProtKB/TrEMBL
      A0A8I6G5K4
    2. XM_063285795.1XP_063141865.1  rhotekin isoform X7

      UniProtKB/TrEMBL
      A0A8I6G5K4
    3. XM_039107325.2XP_038963253.1  rhotekin isoform X4

      UniProtKB/TrEMBL
      A0A8I6G5K4
      Conserved Domains (3) summary
      pfam08174
      Location:67220
      Anillin; Cell division protein anillin
      cl00087
      Location:141
      HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases
      cl17171
      Location:259369
      PH-like; Pleckstrin homology-like domain
    4. XM_063285797.1XP_063141867.1  rhotekin isoform X9

    5. XM_063285794.1XP_063141864.1  rhotekin isoform X7

      UniProtKB/TrEMBL
      A0A8I6G5K4
    6. XM_063285793.1XP_063141863.1  rhotekin isoform X6

      UniProtKB/TrEMBL
      A0A8I6G5K4
    7. XM_063285796.1XP_063141866.1  rhotekin isoform X8

    8. XM_008763038.4XP_008761260.1  rhotekin isoform X3

      See identical proteins and their annotated locations for XP_008761260.1

      UniProtKB/TrEMBL
      A0A8L2UPK3
      Conserved Domains (4) summary
      smart00742
      Location:80135
      Hr1; Rho effector or protein kinase C-related kinase homology region 1 homologues
      pfam00169
      Location:377455
      PH; PH domain
      pfam08174
      Location:161314
      Anillin; Cell division protein anillin
      cl17171
      Location:353463
      PH-like; Pleckstrin homology-like domain
    9. XM_008763037.4XP_008761259.1  rhotekin isoform X2

      See identical proteins and their annotated locations for XP_008761259.1

      UniProtKB/TrEMBL
      A0A8L2UPK3
      Conserved Domains (4) summary
      smart00742
      Location:80135
      Hr1; Rho effector or protein kinase C-related kinase homology region 1 homologues
      pfam00169
      Location:307385
      PH; PH domain
      pfam08174
      Location:161244
      Anillin; Cell division protein anillin
      cl17171
      Location:283393
      PH-like; Pleckstrin homology-like domain
    10. XM_008763034.4XP_008761256.1  rhotekin isoform X1

      See identical proteins and their annotated locations for XP_008761256.1

      UniProtKB/TrEMBL
      A0A8L2UPK3
      Related
      ENSRNOP00000069449.3, ENSRNOT00000079547.3
      Conserved Domains (4) summary
      smart00742
      Location:80135
      Hr1; Rho effector or protein kinase C-related kinase homology region 1 homologues
      pfam00169
      Location:377455
      PH; PH domain
      pfam08174
      Location:161314
      Anillin; Cell division protein anillin
      cl17171
      Location:353463
      PH-like; Pleckstrin homology-like domain