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    Pde7b phosphodiesterase 7B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 140929, updated on 14-Nov-2024

    Summary

    Official Symbol
    Pde7bprovided by RGD
    Official Full Name
    phosphodiesterase 7Bprovided by RGD
    Primary source
    RGD:621016
    See related
    EnsemblRapid:ENSRNOG00000013436 AllianceGenome:RGD:621016
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables 3',5'-cyclic-AMP phosphodiesterase activity. Predicted to be involved in cAMP-mediated signaling. Predicted to be active in cytosol; nucleus; and perinuclear region of cytoplasm. Orthologous to human PDE7B (phosphodiesterase 7B). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 117.0), Muscle (RPKM 90.9) and 9 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Pde7b in Genome Data Viewer
    Location:
    1p12
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (16994072..17312828, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (15174001..15493267, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (15889845..16203909, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene BCL2-associated transcription factor 1 Neighboring gene mitochondrial fission regulator 2 Neighboring gene uncharacterized LOC134484964 Neighboring gene uncharacterized LOC134484963 Neighboring gene histidine-rich glycoprotein-like Neighboring gene uncharacterized LOC120098802 Neighboring gene small nucleolar RNA SNORA41

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 3',5'-cyclic-AMP phosphodiesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables 3',5'-cyclic-AMP phosphodiesterase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables 3',5'-cyclic-AMP phosphodiesterase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables 3',5'-cyclic-GMP phosphodiesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in cAMP-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cAMP-mediated signaling TAS
    Traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    3',5'-cyclic-AMP phosphodiesterase 7B
    Names
    cAMP-specific 3',5'-cyclic phosphodiesterase 7B
    NP_543170.1
    XP_008756813.1
    XP_008756814.1
    XP_038938754.1
    XP_038938792.1
    XP_038938818.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_080894.2NP_543170.1  3',5'-cyclic-AMP phosphodiesterase 7B

      See identical proteins and their annotated locations for NP_543170.1

      Status: PROVISIONAL

      Source sequence(s)
      AB057409
      UniProtKB/TrEMBL
      A6JPD2, Q8VIE4
      Related
      ENSRNOP00000070401.1, ENSRNOT00000078586.3
      Conserved Domains (1) summary
      pfam00233
      Location:172406
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      16994072..17312828 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039082826.2XP_038938754.1  3',5'-cyclic-AMP phosphodiesterase 7B isoform X2

      UniProtKB/TrEMBL
      A6JPD3
      Conserved Domains (1) summary
      pfam00233
      Location:224427
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    2. XM_039082864.2XP_038938792.1  3',5'-cyclic-AMP phosphodiesterase 7B isoform X3

      UniProtKB/TrEMBL
      A0A8I6AIQ8, F1LN39, Q8VIE2
      Related
      ENSRNOP00000018556.6, ENSRNOT00000018556.8
      Conserved Domains (1) summary
      pfam00233
      Location:185419
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    3. XM_008758591.4XP_008756813.1  3',5'-cyclic-AMP phosphodiesterase 7B isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZWQ4, A6JPD3
      Related
      ENSRNOP00000094058.2, ENSRNOT00000101303.2
      Conserved Domains (1) summary
      pfam00233
      Location:224458
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    4. XM_039082890.2XP_038938818.1  3',5'-cyclic-AMP phosphodiesterase 7B isoform X4

      UniProtKB/TrEMBL
      A0A8I6A9G5, Q8VIE3
      Conserved Domains (1) summary
      pfam00233
      Location:85319
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    5. XM_008758592.4XP_008756814.1  3',5'-cyclic-AMP phosphodiesterase 7B isoform X4

      See identical proteins and their annotated locations for XP_008756814.1

      UniProtKB/TrEMBL
      A0A8I6A9G5, Q8VIE3
      Related
      ENSRNOP00000088274.2, ENSRNOT00000117741.2
      Conserved Domains (1) summary
      pfam00233
      Location:85319
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    RNA

    1. XR_005488707.2 RNA Sequence