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    Bclaf1 BCL2-associated transcription factor 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 293017, updated on 3-Dec-2024

    Summary

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    Official Symbol
    Bclaf1provided by RGD
    Official Full Name
    BCL2-associated transcription factor 1provided by RGD
    Primary source
    RGD:1309704
    See related
    EnsemblRapid:ENSRNOG00000058050 AllianceGenome:RGD:1309704
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Aa2-041
    Summary
    Predicted to enable DNA binding activity. Predicted to be involved in DNA damage response; positive regulation of DNA-templated transcription initiation; and positive regulation of intrinsic apoptotic signaling pathway. Predicted to act upstream of or within cellular response to leukemia inhibitory factor; negative regulation of DNA-templated transcription; and positive regulation of apoptotic process. Predicted to be located in nuclear speck. Orthologous to human BCLAF1 (BCL2 associated transcription factor 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 523.8), Adrenal (RPKM 431.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Bclaf1 in Genome Data Viewer
    Location:
    1p12
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (16904572..16937106)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (15088436..15117666)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (15799753..15828838)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene microtubule-associated protein 7 Neighboring gene uncharacterized LOC120098801 Neighboring gene U6 spliceosomal RNA Neighboring gene mitochondrial fission regulator 2 Neighboring gene phosphodiesterase 7B Neighboring gene uncharacterized LOC134484964

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Protein kinase C delta induces transcription of the TP53 tumor suppressor gene by controlling death-promoting factor Btf in the apoptotic response to DNA damage. Liu H, et al. Mol Cell Biol, 2007 Dec. PMID 17938203, Free PMC Article
    2. Btf, a novel death-promoting transcriptional repressor that interacts with Bcl-2-related proteins. Kasof GM, et al. Mol Cell Biol, 1999 Jun. PMID 10330179, Free PMC Article
    3. Identification of Wilms' tumor 1-associating protein complex and its role in alternative splicing and the cell cycle. Horiuchi K, et al. J Biol Chem, 2013 Nov 15. PMID 24100041, Free PMC Article
    4. Involvement of Bcl-2-associated transcription factor 1 in the differentiation of early-born retinal cells. Orieux G, et al. J Neurosci, 2014 Jan 22. PMID 24453340, Free PMC Article
    5. miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic stem cells. Tarantino C, et al. FASEB J, 2010 Sep. PMID 20439489

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in aerobic respiration IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cellular response to leukemia inhibitory factor ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrial fission IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-templated transcription initiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of intrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    bcl-2-associated transcription factor 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001047852.2 → NP_001041317.2  bcl-2-associated transcription factor 1

      See identical proteins and their annotated locations for NP_001041317.2

      Status: PROVISIONAL

      Source sequence(s)
      BC161968
      UniProtKB/TrEMBL
      A0A8I5Y6Z0, B1WC16
      Related
      ENSRNOP00000072352.3, ENSRNOT00000089966.3
      Conserved Domains (2) summary
      pfam15440
      Location:157 → 746
      THRAP3_BCLAF1; THRAP3/BCLAF1 family
      cl09653
      Location:828 → 893
      Btz; CASC3/Barentsz eIF4AIII binding

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      16904572..16937106
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063284458.1 → XP_063140528.1  bcl-2-associated transcription factor 1 isoform X2

      UniProtKB/TrEMBL
      A0A8I5Y6Z0, B1WC16

    2. XM_063284466.1 → XP_063140536.1  bcl-2-associated transcription factor 1 isoform X4

      UniProtKB/TrEMBL
      A0A8I5Y6Z0

    3. XM_063284478.1 → XP_063140548.1  bcl-2-associated transcription factor 1 isoform X6

      UniProtKB/TrEMBL
      A0A0G2JU04
      Related
      ENSRNOP00000097938.2, ENSRNOT00000094509.2

    4. XM_063284485.1 → XP_063140555.1  bcl-2-associated transcription factor 1 isoform X7

    5. XM_063284439.1 → XP_063140509.1  bcl-2-associated transcription factor 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I5Y6Z0, A0A8I6AX06

    6. XM_006227654.5 → XP_006227716.1  bcl-2-associated transcription factor 1 isoform X3

      UniProtKB/TrEMBL
      A0A8I5Y6Z0
      Conserved Domains (2) summary
      pfam15440
      Location:155 → 741
      THRAP3_BCLAF1; THRAP3/BCLAF1 family
      cl09653
      Location:826 → 891
      Btz; CASC3/Barentsz eIF4AIII binding

    7. XM_006227652.5 → XP_006227714.1  bcl-2-associated transcription factor 1 isoform X2

      See identical proteins and their annotated locations for XP_006227714.1

      UniProtKB/TrEMBL
      A0A8I5Y6Z0, B1WC16
      Conserved Domains (2) summary
      pfam15440
      Location:157 → 746
      THRAP3_BCLAF1; THRAP3/BCLAF1 family
      cl09653
      Location:828 → 893
      Btz; CASC3/Barentsz eIF4AIII binding

    8. XM_006227653.4 → XP_006227715.1  bcl-2-associated transcription factor 1 isoform X2

      See identical proteins and their annotated locations for XP_006227715.1

      UniProtKB/TrEMBL
      A0A8I5Y6Z0, B1WC16
      Related
      ENSRNOP00000076713.2, ENSRNOT00000100188.2
      Conserved Domains (2) summary
      pfam15440
      Location:157 → 746
      THRAP3_BCLAF1; THRAP3/BCLAF1 family
      cl09653
      Location:828 → 893
      Btz; CASC3/Barentsz eIF4AIII binding

    9. XM_063284449.1 → XP_063140519.1  bcl-2-associated transcription factor 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I5Y6Z0, A0A8I6AX06
      Related
      ENSRNOP00000071825.3, ENSRNOT00000088025.3

    10. XM_039105467.2 → XP_038961395.1  bcl-2-associated transcription factor 1 isoform X3

      UniProtKB/TrEMBL
      A0A8I5Y6Z0
      Related
      ENSRNOP00000068911.3, ENSRNOT00000078589.3
      Conserved Domains (2) summary
      pfam15440
      Location:155 → 741
      THRAP3_BCLAF1; THRAP3/BCLAF1 family
      cl09653
      Location:826 → 891
      Btz; CASC3/Barentsz eIF4AIII binding

    11. XM_063284473.1 → XP_063140543.1  bcl-2-associated transcription factor 1 isoform X5

      UniProtKB/TrEMBL
      A0A8I5Y6Z0

    RNA

    1. XR_010064690.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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