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    Bola3 bolA family member 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 297388, updated on 27-Nov-2024

    Summary

    Official Symbol
    Bola3provided by RGD
    Official Full Name
    bolA family member 3provided by RGD
    Primary source
    RGD:1305975
    See related
    EnsemblRapid:ENSRNOG00000021866 AllianceGenome:RGD:1305975
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1305975
    Summary
    Predicted to be involved in protein maturation by [4Fe-4S] cluster transfer. Predicted to be located in cytosol; mitochondrion; and nuclear body. Predicted to be part of iron-sulfur cluster assembly complex. Predicted to be active in mitochondrial matrix. Human ortholog(s) of this gene implicated in multiple mitochondrial dysfunctions syndrome 2. Orthologous to human BOLA3 (bolA family member 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Heart (RPKM 247.4), Muscle (RPKM 195.4) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Bola3 in Genome Data Viewer
    Location:
    4q34
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (117411044..117420491)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (115853350..115862797)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (115046693..115056140)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase Neighboring gene uncharacterized LOC134486597 Neighboring gene MOB kinase activator 1A Neighboring gene tet methylcytosine dioxygenase 3 Neighboring gene uncharacterized LOC102548361 Neighboring gene uncharacterized LOC134486594 Neighboring gene deoxyguanosine kinase

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    acts_upstream_of_or_within adaptive thermogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in biological_process ND
    No biological Data available
    more info
     
    acts_upstream_of_or_within energy homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within glucose metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within iron-sulfur cluster assembly ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within protein lipoylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein maturation by [4Fe-4S] cluster transfer IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within response to lipoic acid ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    part_of iron-sulfur cluster assembly complex ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear body IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    bolA-like protein 3
    Names
    bolA homolog 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106601.1NP_001100071.1  bolA-like protein 3

      See identical proteins and their annotated locations for NP_001100071.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473957
      UniProtKB/TrEMBL
      A6IAM1, D3ZT98
      Related
      ENSRNOP00000030813.4, ENSRNOT00000031583.6
      Conserved Domains (1) summary
      cl00386
      Location:38109
      BolA; BolA-like protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      117411044..117420491
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039107335.2XP_038963263.1  bolA-like protein 3 isoform X1

      Conserved Domains (1) summary
      cl00386
      Location:1182
      BolA; BolA-like protein