U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Tlx2 T-cell leukemia homeobox 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 680117, updated on 27-Nov-2024

    Summary

    Official Symbol
    Tlx2provided by RGD
    Official Full Name
    T-cell leukemia homeobox 2provided by RGD
    Primary source
    RGD:1595506
    See related
    EnsemblRapid:ENSRNOG00000055188 AllianceGenome:RGD:1595506
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Hox11L.1
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in animal organ development and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within enteric nervous system development; mesoderm formation; and negative regulation of dendrite morphogenesis. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Orthologous to human TLX2 (T cell leukemia homeobox 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward (RPKM 19.6) See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Tlx2 in Genome Data Viewer
    Location:
    4q34
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (117131516..117133359, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (115573736..115576097, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (114766401..114768243, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene AUP1, lipid droplet regulating VLDL assembly factor Neighboring gene DEAQ box RNA-dependent ATPase 1 Neighboring gene polycomb group ring finger 1 Neighboring gene ladybird homeobox 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    T-cell leukemia homeobox protein 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001172125.1NP_001165596.1  T-cell leukemia homeobox protein 2

      See identical proteins and their annotated locations for NP_001165596.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A0A0G2JVZ2, A6IAJ7
      Related
      ENSRNOP00000069677.1, ENSRNOT00000087788.3
      Conserved Domains (1) summary
      pfam00046
      Location:160213
      Homeobox; Homeobox domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      117131516..117133359 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)