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    Lama2 laminin subunit alpha 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 309368, updated on 3-Dec-2024

    Summary

    Official Symbol
    Lama2provided by RGD
    Official Full Name
    laminin subunit alpha 2provided by RGD
    Primary source
    RGD:1308889
    See related
    EnsemblRapid:ENSRNOG00000011134 AllianceGenome:RGD:1308889
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be an extracellular matrix structural constituent. Involved in Schwann cell differentiation. Located in basement membrane and dendritic spine. Biomarker of renovascular hypertension. Human ortholog(s) of this gene implicated in autosomal recessive limb-girdle muscular dystrophy; congenital merosin-deficient muscular dystrophy 1A; muscular dystrophy; and myopia. Orthologous to human LAMA2 (laminin subunit alpha 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Heart (RPKM 674.5), Muscle (RPKM 322.3) and 7 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Lama2 in Genome Data Viewer
    Location:
    1p12
    Exon count:
    67
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (19492126..20140056)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (17672675..18320641)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (18491264..19143486)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein lateral stalk subunit P0, pseudogene 4 Neighboring gene RuvB-like AAA ATPase 1, pseudogene 2 Neighboring gene U6 spliceosomal RNA Neighboring gene nucleophosmin 1, pseudogene 5 Neighboring gene uncharacterized LOC120098807 Neighboring gene U6 spliceosomal RNA Neighboring gene LSM5 homolog, U6 small nuclear RNA associated Neighboring gene Rho GTPase activating protein 18

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables extracellular matrix structural constituent IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables signaling receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in Schwann cell differentiation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in animal organ morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in axon guidance IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within axon guidance ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within positive regulation of synaptic transmission, cholinergic ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of embryonic development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in tissue development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in basement membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in basement membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in basement membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendritic spine IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in neuromuscular junction ISO
    Inferred from Sequence Orthology
    more info
     
    located_in sarcolemma ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in synaptic cleft ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    laminin subunit alpha-2
    Names
    laminin, alpha 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427039.1NP_001413968.1  laminin subunit alpha-2 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A0G2JWX2, F1M614

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      19492126..20140056
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063264627.1XP_063120697.1  laminin subunit alpha-2 isoform X1

      UniProtKB/TrEMBL
      F1M614
    2. XM_063264628.1XP_063120698.1  laminin subunit alpha-2 isoform X2

      UniProtKB/TrEMBL
      F1M614
    3. XM_063264630.1XP_063120700.1  laminin subunit alpha-2 isoform X4

      UniProtKB/TrEMBL
      F1M614
    4. XM_063264632.1XP_063120702.1  laminin subunit alpha-2 isoform X5

      UniProtKB/TrEMBL
      A0A8I5ZPP7, F1M614
      Related
      ENSRNOP00000070049.3, ENSRNOT00000079138.3
    5. XM_063264629.1XP_063120699.1  laminin subunit alpha-2 isoform X3

      UniProtKB/TrEMBL
      F1M614
    6. XM_063264637.1XP_063120707.1  laminin subunit alpha-2 isoform X6

      UniProtKB/TrEMBL
      F1M614
    7. XM_063264642.1XP_063120712.1  laminin subunit alpha-2 isoform X7

      UniProtKB/TrEMBL
      A6JPF2, F1M614
      Related
      ENSRNOP00000014917.9, ENSRNOT00000014917.9