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    Arhgap18 Rho GTPase activating protein 18 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 293947, updated on 27-Nov-2024

    Summary

    Official Symbol
    Arhgap18provided by RGD
    Official Full Name
    Rho GTPase activating protein 18provided by RGD
    Primary source
    RGD:1305053
    See related
    EnsemblRapid:ENSRNOG00000011245 AllianceGenome:RGD:1305053
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable GTPase activator activity. Predicted to be involved in several processes, including regulation of actin filament polymerization; regulation of small GTPase mediated signal transduction; and small GTPase-mediated signal transduction. Predicted to be located in several cellular components, including cytoplasmic microtubule; nuclear speck; and ruffle. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human ARHGAP18 (Rho GTPase activating protein 18). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 204.7), Heart (RPKM 177.4) and 9 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Arhgap18 in Genome Data Viewer
    Location:
    1p12
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (20222948..20456827, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (18403531..18637306, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (19227115..19463139, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene laminin subunit alpha 2 Neighboring gene uncharacterized LOC120098807 Neighboring gene U6 spliceosomal RNA Neighboring gene LSM5 homolog, U6 small nuclear RNA associated Neighboring gene cytochrome b-c1 complex subunit 10-like Neighboring gene ribosomal protein S10 like 2 Neighboring gene L3MBTL histone methyl-lysine binding protein 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GTPase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in ruffle ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    rho GTPase-activating protein 18

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001170575.1NP_001164046.1  rho GTPase-activating protein 18

      See identical proteins and their annotated locations for NP_001164046.1

      Status: VALIDATED

      Source sequence(s)
      CB579768, CK367489, CV116120, FM089382, FM117434
      UniProtKB/TrEMBL
      A6JPF6, F1LXP8
      Related
      ENSRNOP00000015548.5, ENSRNOT00000015547.8
      Conserved Domains (1) summary
      cd04391
      Location:323536
      RhoGAP_ARHGAP18; RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP18-like proteins. The function of ArhGAP18 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      20222948..20456827 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017589037.3XP_017444526.1  rho GTPase-activating protein 18 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A5D2
      Related
      ENSRNOP00000087899.1, ENSRNOT00000096976.2
    2. XM_006227680.5XP_006227742.1  rho GTPase-activating protein 18 isoform X2

      Conserved Domains (1) summary
      cd04391
      Location:278491
      RhoGAP_ARHGAP18; RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP18-like proteins. The function of ArhGAP18 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their ...
    3. XM_039108944.2XP_038964872.1  rho GTPase-activating protein 18 isoform X3

      Conserved Domains (1) summary
      cl02570
      Location:323365
      RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001106354.1: Suppressed sequence

      Description
      NM_001106354.1: This RefSeq was permanently suppressed because there is currently insufficient support for the transcript and the protein.