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    Chtf18 chromosome transmission fidelity factor 18 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 287146, updated on 14-Nov-2024

    Summary

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    Official Symbol
    Chtf18provided by RGD
    Official Full Name
    chromosome transmission fidelity factor 18provided by RGD
    Primary source
    RGD:1310473
    See related
    EnsemblRapid:ENSRNOG00000019174 AllianceGenome:RGD:1310473
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable DNA binding activity. Predicted to contribute to DNA clamp loader activity and single-stranded DNA helicase activity. Predicted to be involved in positive regulation of DNA-directed DNA polymerase activity. Predicted to act upstream of or within germ cell development; meiotic nuclear division; and negative regulation of chromosome segregation. Predicted to be located in cytosol; male germ cell nucleus; and nucleoplasm. Predicted to be part of Ctf18 RFC-like complex. Predicted to be active in nucleus. Orthologous to human CHTF18 (chromosome transmission fidelity factor 18). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 38.6), Spleen (RPKM 27.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Chtf18 in Genome Data Viewer
    Location:
    10q12
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (15247525..15255573, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (14743006..14751044, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (15090762..15098825, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene lipase maturation factor 1 Neighboring gene uncharacterized LOC120095315 Neighboring gene G protein subunit gamma 13 Neighboring gene RNA pseudouridine synthase domain containing 1 Neighboring gene mesothelin-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Germline expression of mammalian CTF18, an evolutionarily conserved protein required for germ cell proliferation in the fly and sister chromatid cohesion in yeast. Berkowitz KM, et al. Mol Hum Reprod, 2008 Mar. PMID 18250106
    2. Disruption of CHTF18 causes defective meiotic recombination in male mice. Berkowitz KM, et al. PLoS Genet, 2012. PMID 23133398, Free PMC Article
    3. The alternative Ctf18-Dcc1-Ctf8-replication factor C complex required for sister chromatid cohesion loads proliferating cell nuclear antigen onto DNA. Bermudez VP, et al. Proc Natl Acad Sci U S A, 2003 Sep 2. PMID 12930902, Free PMC Article
    4. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to DNA clamp loader activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to DNA clamp loader activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to single-stranded DNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to single-stranded DNA helicase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA duplex unwinding IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of chromosome segregation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within germ cell development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within male meiotic nuclear division ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of chromosome segregation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-directed DNA polymerase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within reciprocal meiotic recombination ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of Ctf18 RFC-like complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in male germ cell nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    chromosome transmission fidelity protein 18 homolog
    Names
    CTF18, chromosome transmission fidelity factor 18 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001105773.1 → NP_001099243.1  chromosome transmission fidelity protein 18 homolog

      See identical proteins and their annotated locations for NP_001099243.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473948
      UniProtKB/TrEMBL
      A0A8I6ALU6, A6HD39, D4AC99
      Related
      ENSRNOP00000026139.8, ENSRNOT00000026139.8
      Conserved Domains (2) summary
      cd00009
      Location:345 → 515
      AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
      cl19912
      Location:485 → 552
      DNA_pol3_delta; DNA polymerase III, delta subunit

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      15247525..15255573 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006245936.5 → XP_006245998.1  chromosome transmission fidelity protein 18 homolog isoform X1

      UniProtKB/TrEMBL
      D4AC99
      Related
      ENSRNOP00000089836.2, ENSRNOT00000099898.2
      Conserved Domains (2) summary
      cd00009
      Location:346 → 516
      AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
      cl19912
      Location:486 → 553
      DNA_pol3_delta; DNA polymerase III, delta subunit

    2. XM_017597066.3 → XP_017452555.1  chromosome transmission fidelity protein 18 homolog isoform X2

      UniProtKB/TrEMBL
      D4AC99
    Nucleotide Protein Strain
    Heading Accession and Version

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