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    Wfikkn1 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 363555, updated on 9-Dec-2024

    Summary

    Official Symbol
    Wfikkn1provided by RGD
    Official Full Name
    WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1provided by RGD
    Primary source
    RGD:1565835
    See related
    AllianceGenome:RGD:1565835
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Oc29; RGD1565835
    Summary
    Predicted to enable receptor antagonist activity and transforming growth factor beta binding activity. Predicted to be involved in negative regulation of transforming growth factor beta receptor signaling pathway and transforming growth factor beta receptor signaling pathway. Predicted to act upstream of or within muscle cell development; roof of mouth development; and skeletal system development. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Orthologous to human WFIKKN1 (WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 47.8), Adrenal (RPKM 37.5) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Wfikkn1 in Genome Data Viewer
    Location:
    10q12
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (15400953..15403280, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (14896442..14898770, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (15243429..15245757, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene MAPK regulated co-repressor interacting protein 2 Neighboring gene methyltransferase like 26 Neighboring gene transfer RNA glycine (anticodon CCC) 5 Neighboring gene Rab40c, member RAS oncogene family Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class Q Neighboring gene uncharacterized LOC134480763

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables receptor antagonist activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables receptor antagonist activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables receptor antagonist activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transforming growth factor beta binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables transforming growth factor beta binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables transforming growth factor beta binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular region ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 1
    Names
    WAP, FS, Ig, KU, and NTR-containing protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001129776.1NP_001123248.1  WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 1 precursor

      See identical proteins and their annotated locations for NP_001123248.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473948
      UniProtKB/Swiss-Prot
      P0C5J5
      UniProtKB/TrEMBL
      A0A8L2UMW2
      Conserved Domains (7) summary
      cd05765
      Location:204284
      Ig_3; Subgroup of the immunoglobulin (Ig) superfamily
      smart00131
      Location:361413
      KU; BPTI/Kunitz family of serine protease inhibitors
      cd00104
      Location:124159
      KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
      pfam07679
      Location:196284
      I-set; Immunoglobulin I-set domain
      pfam00095
      Location:3480
      WAP; WAP-type (Whey Acidic Protein) 'four-disulfide core'
      cl00101
      Location:311356
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
      cl02512
      Location:431541
      NTR_like; NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      15400953..15403280 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)