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    Ciao3 cytosolic iron-sulfur assembly component 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360496, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ciao3provided by RGD
    Official Full Name
    cytosolic iron-sulfur assembly component 3provided by RGD
    Primary source
    RGD:1305982
    See related
    EnsemblRapid:ENSRNOG00000019522 AllianceGenome:RGD:1305982
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Narfl
    Summary
    Predicted to enable 4 iron, 4 sulfur cluster binding activity and metal ion binding activity. Predicted to be involved in several processes, including intracellular oxygen homeostasis; iron-sulfur cluster assembly; and response to hypoxia. Predicted to act upstream of or within hematopoietic progenitor cell differentiation. Predicted to be part of cytosolic [4Fe-4S] assembly targeting complex. Orthologous to human CIAO3 (cytosolic iron-sulfur assembly component 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 193.3), Muscle (RPKM 142.3) and 9 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Ciao3 in Genome Data Viewer
    Location:
    10q12
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (15300403..15309467)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (14795888..14804953)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (15143732..15152706)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene mesothelin-like Neighboring gene mesothelin Neighboring gene hydroxyacylglutathione hydrolase-like Neighboring gene coiled-coil domain containing 78 Neighboring gene adenine nucleotide translocase lysine methyltransferase

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Clone Names

    • MGC109005

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 4 iron, 4 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in hematopoietic progenitor cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within hematopoietic progenitor cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intracellular oxygen homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in intracellular oxygen homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in iron-sulfur cluster assembly IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within iron-sulfur cluster assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in iron-sulfur cluster assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in iron-sulfur cluster assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to hypoxia IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of cytosolic [4Fe-4S] assembly targeting complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of cytosolic [4Fe-4S] assembly targeting complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of cytosolic [4Fe-4S] assembly targeting complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of cytosolic [4Fe-4S] assembly targeting complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    cytosolic iron-sulfur assembly component 3
    Names
    IOP1
    cytosolic Fe-S cluster assembly factor NARFL
    iron-only hydrogenase-like protein 1
    nuclear prelamin A recognition factor-like protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013183.1NP_001013201.1  cytosolic iron-sulfur assembly component 3

      See identical proteins and their annotated locations for NP_001013201.1

      Status: PROVISIONAL

      Source sequence(s)
      BC091240
      UniProtKB/Swiss-Prot
      Q5BK18
      UniProtKB/TrEMBL
      A6HD46
      Conserved Domains (2) summary
      smart00902
      Location:418466
      Fe_hyd_SSU; Iron hydrogenase small subunit
      pfam02906
      Location:112403
      Fe_hyd_lg_C; Iron only hydrogenase large subunit, C-terminal domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      15300403..15309467
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039086277.2XP_038942205.1  cytosolic iron-sulfur assembly component 3 isoform X3

      Conserved Domains (1) summary
      pfam02906
      Location:112348
      Fe_hyd_lg_C; Iron only hydrogenase large subunit, C-terminal domain
    2. XM_039086276.2XP_038942204.1  cytosolic iron-sulfur assembly component 3 isoform X2

      Related
      ENSRNOP00000108952.1, ENSRNOT00000144894.1
      Conserved Domains (2) summary
      smart00902
      Location:399447
      Fe_hyd_SSU; Iron hydrogenase small subunit
      pfam02906
      Location:93384
      Fe_hyd_lg_C; Iron only hydrogenase large subunit, C-terminal domain
    3. XM_039086275.2XP_038942203.1  cytosolic iron-sulfur assembly component 3 isoform X1

      UniProtKB/TrEMBL
      A0A8L2QFN5
      Related
      ENSRNOP00000026518.4, ENSRNOT00000026518.7
      Conserved Domains (2) summary
      smart00902
      Location:413461
      Fe_hyd_SSU; Iron hydrogenase small subunit
      pfam02906
      Location:107398
      Fe_hyd_lg_C; Iron only hydrogenase large subunit, C-terminal domain
    4. XM_039086278.2XP_038942206.1  cytosolic iron-sulfur assembly component 3 isoform X4

      Conserved Domains (2) summary
      smart00902
      Location:234282
      Fe_hyd_SSU; Iron hydrogenase small subunit
      pfam02906
      Location:1219
      Fe_hyd_lg_C; Iron only hydrogenase large subunit, C-terminal domain