Abhd2 abhydrolase domain containing 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Abhd2provided by MGI
Official Full Name: abhydrolase domain containing 2provided by MGI
Primary source: MGI:MGI:1914344
See related: Ensembl:ENSMUSG00000039202 AllianceGenome:MGI:1914344
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: LABH2; Labh-2; 2210009N18Rik
Summary: Predicted to enable carboxylic ester hydrolase activity; hormone binding activity; and nuclear steroid receptor activity. Involved in acrosome reaction. Acts upstream of or within negative regulation of smooth muscle cell migration and response to wounding. Located in acrosomal vesicle. Is expressed in several structures, including cardiovascular system; central nervous system; endocrine gland; genitourinary system; and sensory organ. Orthologous to human ABHD2 (abhydrolase domain containing 2, acylglycerol lipase). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in genital fat pad adult (RPKM 82.7), adrenal adult (RPKM 56.2) and 22 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 44.96 cM; 7 D2

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (78923002..79015257)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (79273266..79361601)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Abhd2, a Candidate Gene Regulating Airway Remodeling in COPD via TGF-beta.
Title: Abhd2, a Candidate Gene Regulating Airway Remodeling in COPD via TGF-β.
ABHD2 deficiency aggravates ovalbumin-induced airway remodeling through the PI3K/Akt pathway in an animal model of chronic asthma.
Title: ABHD2 deficiency aggravates ovalbumin-induced airway remodeling through the PI3K/Akt pathway in an animal model of chronic asthma.
Lipidomic QTL in Diversity Outbred mice identifies a novel function for alpha/beta hydrolase domain 2 (Abhd2) as an enzyme that metabolizes phosphatidylcholine and cardiolipin.
Title: Lipidomic QTL in Diversity Outbred mice identifies a novel function for α/β hydrolase domain 2 (Abhd2) as an enzyme that metabolizes phosphatidylcholine and cardiolipin.
These findings suggest that derangement in alveolar phospholipid metabolism can induce emphysema, and that Abhd2 plays a critical role in maintaining lung structural integrity.
Title: Age-related pulmonary emphysema in mice lacking alpha/beta hydrolase domain containing 2 gene.
LABH-2 protein is a member of a novel family of membrane bound enzymes whose function has yet to be determined; highest expression level in the testis
Title: Cloning and tissue distribution of three murine alpha/beta hydrolase fold protein cDNAs.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation
Gene trapped (2) 1 citation
Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

07.MMHAP24FLC1.seq (e-PCR)
- UniSTS:122881

Abhd2 (e-PCR), detects polymorphism
- UniSTS:265209

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables acetylesterase activity	IBA Inferred from Biological aspect of Ancestor more info
enables acetylesterase activity	ISO Inferred from Sequence Orthology more info
enables acetylesterase activity	ISS Inferred from Sequence or Structural Similarity more info
enables diacylglycerol lipase activity	ISO Inferred from Sequence Orthology more info
enables diacylglycerol lipase activity	ISS Inferred from Sequence or Structural Similarity more info
enables hormone binding	ISO Inferred from Sequence Orthology more info
enables hormone binding	ISS Inferred from Sequence or Structural Similarity more info
enables monoacylglycerol lipase activity	IBA Inferred from Biological aspect of Ancestor more info
enables monoacylglycerol lipase activity	ISO Inferred from Sequence Orthology more info
enables monoacylglycerol lipase activity	ISS Inferred from Sequence or Structural Similarity more info
enables nuclear steroid receptor activity	ISO Inferred from Sequence Orthology more info
enables nuclear steroid receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables triacylglycerol lipase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in acrosome reaction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in acylglycerol catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in acylglycerol catabolic process	ISO Inferred from Sequence Orthology more info
involved_in acylglycerol catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in medium-chain fatty acid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in medium-chain fatty acid catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of smooth muscle cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to progesterone	ISO Inferred from Sequence Orthology more info
involved_in response to progesterone	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within response to wounding	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of smooth muscle cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sperm capacitation	IBA Inferred from Biological aspect of Ancestor more info
involved_in sperm capacitation	IEA Inferred from Electronic Annotation more info
involved_in sperm capacitation	ISO Inferred from Sequence Orthology more info
involved_in steroid hormone receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in steroid hormone receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in steroid hormone receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in acrosomal membrane	IEA Inferred from Electronic Annotation more info
located_in acrosomal vesicle	IDA Inferred from Direct Assay more info	PubMed
is_active_in sperm flagellum	IBA Inferred from Biological aspect of Ancestor more info
located_in sperm flagellum	IEA Inferred from Electronic Annotation more info
located_in sperm flagellum	ISO Inferred from Sequence Orthology more info
is_active_in sperm plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in sperm plasma membrane	IEA Inferred from Electronic Annotation more info
located_in sperm plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: monoacylglycerol lipase ABHD2

Names: 2-arachidonoylglycerol hydrolase; abhydrolase domain-containing protein 2; acetylesterase; alpha/beta hydrolase fold protein; lung alpha/beta hydrolase 2; mmLABH2; triacylglycerol lipase

NP_061281.3

EC 3.1.1.23

EC 3.1.1.6

EC 3.1.1.79

XP_036009150.1

EC 3.1.1.23

EC 3.1.1.6

EC 3.1.1.79

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_018811.6 → NP_061281.3 monoacylglycerol lipase ABHD2

See identical proteins and their annotated locations for NP_061281.3

Status: PROVISIONAL

Source sequence(s)

AC160464

Consensus CDS

CCDS21380.1

UniProtKB/Swiss-Prot

Q3U5E8, Q5FWC6, Q9D7Y8, Q9QXM0

Related

ENSMUSP00000038361.7, ENSMUST00000037315.13

Conserved Domains (1) summary

cl21494
Location:65 → 400

Abhydrolase; alpha/beta hydrolases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

78923002..79015257

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036153257.1 → XP_036009150.1 monoacylglycerol lipase ABHD2 isoform X1

UniProtKB/Swiss-Prot

Q3U5E8, Q5FWC6, Q9D7Y8, Q9QXM0

Conserved Domains (1) summary

cl21494
Location:65 → 400

Abhydrolase; alpha/beta hydrolases