Piezo1 piezo-type mechanosensitive ion channel component 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Piezo1provided by MGI
Official Full Name: piezo-type mechanosensitive ion channel component 1provided by MGI
Primary source: MGI:MGI:3603204
See related: Ensembl:ENSMUSG00000014444 AllianceGenome:MGI:3603204
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Fam38a; mKIAA0233; 9630020g22
Summary: Enables identical protein binding activity and mechanosensitive monoatomic cation channel activity. Involved in monoatomic cation transport and positive regulation of myotube differentiation. Acts upstream of or within detection of mechanical stimulus and regulation of membrane potential. Located in cuticular plate; plasma membrane; and stereocilium. Is expressed in several structures, including brain; hemolymphoid system; liver; lung; and skin. Human ortholog(s) of this gene implicated in dehydrated hereditary stomatocytosis 1 and hereditary lymphedema. Orthologous to human PIEZO1 (piezo type mechanosensitive ion channel component 1 (Er blood group)). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in lung adult (RPKM 39.8), ovary adult (RPKM 31.9) and 23 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 E1; 8 71.31 cM

Exon count:: 53

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (123208437..123278068, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (122481698..122551329, complement)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Acute contact with profibrotic macrophages mechanically activates fibroblasts via alphavbeta3 integrin-mediated engagement of Piezo1.
Title: Acute contact with profibrotic macrophages mechanically activates fibroblasts via αvβ3 integrin-mediated engagement of Piezo1.
Mechanosensing by Piezo1 in gastric ghrelin cells contributes to hepatic lipid homeostasis in mice.
Title: Mechanosensing by Piezo1 in gastric ghrelin cells contributes to hepatic lipid homeostasis in mice.
Piezo1 mediates mechanical signals in TRPV1-positive nociceptors in mice.
Title: Piezo1 mediates mechanical signals in TRPV1-positive nociceptors in mice.
Piezo1 activation on microglial cells exacerbates demyelination in sepsis by influencing the CCL25/GRP78 pathway.
Title: Piezo1 activation on microglial cells exacerbates demyelination in sepsis by influencing the CCL25/GRP78 pathway.
Functional coupling between Piezo1 and TRPM4 influences the electrical activity of HL-1 atrial myocytes.
Title: Functional coupling between Piezo1 and TRPM4 influences the electrical activity of HL-1 atrial myocytes.
Piezo1 ion channels are capable of conformational signaling.
Title: Piezo1 ion channels are capable of conformational signaling.
Piezo1 stretch-activated channel activity differs between murine bone marrow-derived and cardiac tissue-resident macrophages.
Title: Piezo1 stretch-activated channel activity differs between murine bone marrow-derived and cardiac tissue-resident macrophages.
Piezo1 mediates the degradation of cartilage extracellular matrix in malocclusion-induced TMJOA.
Title: Piezo1 mediates the degradation of cartilage extracellular matrix in malocclusion-induced TMJOA.
PIEZO1 targeting in macrophages boosts phagocytic activity and foam cell apoptosis in atherosclerosis.
Title: PIEZO1 targeting in macrophages boosts phagocytic activity and foam cell apoptosis in atherosclerosis.
Occlusal force orchestrates alveolar bone homeostasis via Piezo1 in female mice.
Title: Occlusal force orchestrates alveolar bone homeostasis via Piezo1 in female mice.

Submit: New GeneRIF Correction See all GeneRIFs (173)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (7) 1 citation
Gene trapped (1)
Targeted (10) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables mechanosensitive monoatomic cation channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables mechanosensitive monoatomic cation channel activity	ISO Inferred from Sequence Orthology more info
enables mechanosensitive monoatomic ion channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables mechanosensitive monoatomic ion channel activity	IDA Inferred from Direct Assay more info	PubMed
enables mechanosensitive monoatomic ion channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables monoatomic cation channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables monoatomic cation channel activity	IDA Inferred from Direct Assay more info	PubMed
enables monoatomic cation channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to mechanical stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in detection of mechanical stimulus	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within detection of mechanical stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in monoatomic cation transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoatomic cation transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in monoatomic cation transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell-cell adhesion mediated by integrin	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell-cell adhesion mediated by integrin	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of integrin activation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of integrin activation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of myotube differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of myotube differentiation	ISO Inferred from Sequence Orthology more info
involved_in regulation of membrane potential	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of membrane potential	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cuticular plate	IDA Inferred from Direct Assay more info	PubMed
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum-Golgi intermediate compartment membrane	IEA Inferred from Electronic Annotation more info
located_in lamellipodium membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in stereocilium	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: piezo-type mechanosensitive ion channel component 1

Names: family with sequence similarity 38, member A; protein PIEZO1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001037298.1 → NP_001032375.1 piezo-type mechanosensitive ion channel component 1 isoform 2

Status: VALIDATED

Source sequence(s)

AC114917

Consensus CDS

CCDS52695.1

UniProtKB/Swiss-Prot

E2JF22

UniProtKB/TrEMBL

E9PUQ9

Related

ENSMUSP00000089777.6, ENSMUST00000067252.14

Conserved Domains (2) summary

pfam12166
Location:2126 → 2544

Piezo_RRas_bdg; Piezo non-specific cation channel, R-Ras-binding domain

pfam15917
Location:1229 → 1452

PIEZO; Piezo
NM_001357349.1 → NP_001344278.1 piezo-type mechanosensitive ion channel component 1 isoform 1

Status: VALIDATED

Source sequence(s)

AC114917

Consensus CDS

CCDS90474.1

UniProtKB/Swiss-Prot

E2JF22

UniProtKB/TrEMBL

F7AC58

Related

ENSMUSP00000114584.3, ENSMUST00000156333.9

Conserved Domains (2) summary

pfam12166
Location:2127 → 2545

Piezo_RRas_bdg; Piezo non-specific cation channel, R-Ras-binding domain

pfam15917
Location:1230 → 1453

PIEZO; Piezo

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

123208437..123278068 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006530954.2 → XP_006531017.2 piezo-type mechanosensitive ion channel component 1 isoform X2

UniProtKB/Swiss-Prot

E2JF22

Conserved Domains (2) summary

pfam12166
Location:2121 → 2539

Piezo_RRas_bdg; Piezo non-specific cation channel, R-Ras-binding domain

pfam15917
Location:1224 → 1447

PIEZO; Piezo
XM_006530956.2 → XP_006531019.2 piezo-type mechanosensitive ion channel component 1 isoform X3

UniProtKB/Swiss-Prot

E2JF22

Conserved Domains (2) summary

pfam12166
Location:2098 → 2516

Piezo_RRas_bdg; Piezo non-specific cation channel, R-Ras-binding domain

pfam15917
Location:1225 → 1424

PIEZO; Piezo
XM_006530953.2 → XP_006531016.2 piezo-type mechanosensitive ion channel component 1 isoform X1

UniProtKB/Swiss-Prot

E2JF22

Conserved Domains (2) summary

pfam12166
Location:2122 → 2540

Piezo_RRas_bdg; Piezo non-specific cation channel, R-Ras-binding domain

pfam15917
Location:1225 → 1448

PIEZO; Piezo
XM_006530959.3 → XP_006531022.1 piezo-type mechanosensitive ion channel component 1 isoform X5

UniProtKB/TrEMBL

Q80XT7

Conserved Domains (2) summary

pfam12166
Location:1397 → 1815

Piezo_RRas_bdg; Piezo non-specific cation channel, R-Ras-binding domain

pfam15917
Location:500 → 723

PIEZO; Piezo
XM_011248372.2 → XP_011246674.1 piezo-type mechanosensitive ion channel component 1 isoform X6

UniProtKB/TrEMBL

Q6ZQF9

Conserved Domains (2) summary

pfam12166
Location:976 → 1394

Piezo_RRas_bdg; Piezo non-specific cation channel, R-Ras-binding domain

pfam15917
Location:79 → 302

PIEZO; Piezo
XM_006530957.3 → XP_006531020.2 piezo-type mechanosensitive ion channel component 1 isoform X4

UniProtKB/Swiss-Prot

E2JF22

Conserved Domains (2) summary

pfam12166
Location:2122 → 2173

Piezo_RRas_bdg; Piezo non-specific cation channel, R-Ras-binding domain

pfam15917
Location:1225 → 1448

PIEZO; Piezo