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    Iqcn IQ motif containing N [ Mus musculus (house mouse) ]

    Gene ID: 637079, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Iqcnprovided by MGI
    Official Full Name
    IQ motif containing Nprovided by MGI
    Primary source
    MGI:MGI:3708784
    See related
    Ensembl:ENSMUSG00000110622 AllianceGenome:MGI:3708784
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm16486
    Summary
    Involved in spermatid development. Predicted to be located in mitochondrion. Human ortholog(s) of this gene implicated in spermatogenic failure 78. Orthologous to human IQCN (IQ motif containing N). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward testis adult (RPKM 68.7) See more
    Orthologs
    human all
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    Genomic context

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    See Iqcn in Genome Data Viewer
    Location:
    8 B3.3; 8 34.15 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (71154661..71170299)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (70701321..70717650)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 39191 Neighboring gene STARR-positive B cell enhancer ABC_E6647 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:73219441-73219628 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:73222195-73222304 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:73222558-73222745 Neighboring gene STARR-positive B cell enhancer ABC_E6648 Neighboring gene jun D proto-oncogene Neighboring gene predicted gene, 34255 Neighboring gene predicted gene 3336 Neighboring gene phosphodiesterase 4C, cAMP specific

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Loss-of-function mutations in IQCN cause male infertility in humans and mice owing to total fertilization failure. Wang Y, et al. Mol Hum Reprod, 2023 Jun 30. PMID 37184908
    2. Biallelic variants in IQCN cause sperm flagellar assembly defects and male infertility. Li Q, et al. Hum Reprod, 2023 Jul 5. PMID 37140151
    3. IQCN disruption causes fertilization failure and male infertility due to manchette assembly defect. Dai J, et al. EMBO Mol Med, 2022 Dec 7. PMID 36321563, Free PMC Article
    4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Biallelic variants in IQCN cause sperm flagellar assembly defects and male infertility.
      Title: Biallelic variants in IQCN cause sperm flagellar assembly defects and male infertility.
    2. Loss-of-function mutations in IQCN cause male infertility in humans and mice owing to total fertilization failure.
      Title: Loss-of-function mutations in IQCN cause male infertility in humans and mice owing to total fertilization failure.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in spermatid development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spermatid development ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    IQ domain-containing protein N

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001370846.1 → NP_001357775.1  IQ domain-containing protein N

      Status: VALIDATED

      Source sequence(s)
      AC162446
      UniProtKB/Swiss-Prot
      A0A1D5RMD1
      UniProtKB/TrEMBL
      A0A9L6JPS2
      Related
      ENSMUSP00000148728.2, ENSMUST00000212436.2
      Conserved Domains (2) summary
      smart00015
      Location:1360 → 1381
      IQ; Calmodulin-binding motif
      PRK14971
      Location:280 → 384
      PRK14971; DNA polymerase III subunit gamma/tau

    2. NM_001370847.1 → NP_001357776.1  IQ domain-containing protein N

      Status: VALIDATED

      Source sequence(s)
      AC162446
      UniProtKB/Swiss-Prot
      A0A1D5RMD1
      UniProtKB/TrEMBL
      A0A9L6JPS2
      Conserved Domains (2) summary
      smart00015
      Location:1360 → 1381
      IQ; Calmodulin-binding motif
      PRK14971
      Location:280 → 384
      PRK14971; DNA polymerase III subunit gamma/tau

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      71154661..71170299
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036154224.1 → XP_036010117.1  IQ domain-containing protein N isoform X1

      Conserved Domains (3) summary
      smart00015
      Location:3061 → 3082
      IQ; Calmodulin-binding motif
      PHA03247
      Location:1714 → 2275
      PHA03247; large tegument protein UL36; Provisional
      PRK14971
      Location:280 → 384
      PRK14971; DNA polymerase III subunit gamma/tau
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A1D5RMD1.2 GenPept UniProtKB/Swiss-Prot:A0A1D5RMD1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials