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    PARP16 poly(ADP-ribose) polymerase family member 16 [ Homo sapiens (human) ]

    Gene ID: 54956, updated on 10-Dec-2024

    Summary

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    Official Symbol
    PARP16provided by HGNC
    Official Full Name
    poly(ADP-ribose) polymerase family member 16provided by HGNC
    Primary source
    HGNC:HGNC:26040
    See related
    Ensembl:ENSG00000138617 MIM:620391; AllianceGenome:HGNC:26040
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ARTD15; pART15; C15orf30
    Summary
    Enables NAD+-protein ADP-ribosyltransferase activity; kinase binding activity; and protein serine/threonine kinase activator activity. Involved in IRE1-mediated unfolded protein response; negative regulation of cytoplasmic translation; and protein auto-ADP-ribosylation. Located in endoplasmic reticulum tubular network and nuclear envelope. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in ovary (RPKM 4.7), endometrium (RPKM 3.3) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See PARP16 in Genome Data Viewer
    Location:
    15q22.31
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (65230917..65286883, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (63040296..63096236, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (65550437..65579221, complement)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene cartilage intermediate layer protein Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:65504440-65505341 Neighboring gene RNA, U6 small nuclear 686, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:65532106-65532606 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:65532607-65533107 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:65545798-65546298 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6554 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9594 Neighboring gene small nucleolar RNA, H/ACA box 24B Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr15:65588516-65589427 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:65593529-65594044 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6555 Neighboring gene RNA, U5A small nuclear 1 Neighboring gene RNA, U5B small nuclear 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Poly (ADP-ribose) polymerases 16 triggers pathological cardiac hypertrophy via activating IRE1α-sXBP1-GATA4 pathway. Su H, et al. Cell Mol Life Sci, 2023 May 23. PMID 37219631, Free PMC Article
    2. Regulation of nucleocytoplasmic transport by ADP-ribosylation: the emerging role of karyopherin-β1 mono-ADP-ribosylation by ARTD15. Di Girolamo M. Curr Top Microbiol Immunol, 2015. PMID 25037261
    3. Regulation of poly ADP-ribosylation of VEGF by an interplay between PARP-16 and TNKS-2. Kunhiraman H, et al. Mol Cell Biochem, 2020 Aug. PMID 32472322
    4. PARP16/ARTD15 is a novel endoplasmic-reticulum-associated mono-ADP-ribosyltransferase that interacts with, and modifies karyopherin-ß1. Di Paola S, et al. PLoS One, 2012. PMID 22701565, Free PMC Article
    5. Ribosome ADP-ribosylation inhibits translation and maintains proteostasis in cancers. Challa S, et al. Cell, 2021 Aug 19. PMID 34314702, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Poly (ADP-ribose) polymerases 16 triggers pathological cardiac hypertrophy via activating IRE1alpha-sXBP1-GATA4 pathway.
      Title: Poly (ADP-ribose) polymerases 16 triggers pathological cardiac hypertrophy via activating IRE1α-sXBP1-GATA4 pathway.
    2. Regulation of poly ADP-ribosylation of VEGF by an interplay between PARP-16 and TNKS-2.
      Title: Regulation of poly ADP-ribosylation of VEGF by an interplay between PARP-16 and TNKS-2.
    3. ARTD15 plays role in nucleocytoplasmic shuttling, through karyopherin-beta1 mono-ADP-ribosylation. [review]
      Title: Regulation of nucleocytoplasmic transport by ADP-ribosylation: the emerging role of karyopherin-β1 mono-ADP-ribosylation by ARTD15.
    4. PARP16 is a tail-anchored endoplasmic reticulum protein required for the PERK- and IRE1alpha-mediated unfolded protein response.
      Title: PARP16 is a tail-anchored endoplasmic reticulum protein required for the PERK- and IRE1α-mediated unfolded protein response.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ20509, FLJ25281

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables NAD+-histone H2BE18 glutamate ADP-ribosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NAD+-histone H2BE2 glutamate ADP-ribosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NAD+-protein ADP-ribosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables NAD+-protein poly-ADP-ribosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables NAD+-protein poly-ADP-ribosyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables NAD+-protein poly-ADP-ribosyltransferase activity TAS
    Traceable Author Statement
    more info
    		  
    enables NAD+-protein-aspartate ADP-ribosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables NAD+-protein-glutamate ADP-ribosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables NAD+-protein-lysine ADP-ribosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables nucleotidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein serine/threonine kinase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activator activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in IRE1-mediated unfolded protein response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in NAD biosynthesis via nicotinamide riboside salvage pathway TAS
    Traceable Author Statement
    more info
    		  
    involved_in cellular response to leukemia inhibitory factor IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in endoplasmic reticulum unfolded protein response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endoplasmic reticulum unfolded protein response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of cytoplasmic translation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein auto-ADP-ribosylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein auto-ADP-ribosylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in viral protein processing TAS
    Traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in endoplasmic reticulum IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum tubular network IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum tubular network IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in membrane HDA PubMed 
    is_active_in nuclear envelope IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein mono-ADP-ribosyltransferase PARP16
    Names
    ADP-ribosyltransferase diphtheria toxin-like 15
    PARP-16
    mono [ADP-ribose] polymerase PARP16
    poly [ADP-ribose] polymerase 16
    NP_001303872.1
    NP_001303873.1
    NP_060321.3
    XP_006720652.1
    XP_006720653.1
    XP_006720655.1
    XP_011520044.1
    XP_016877875.1
    XP_016877876.1
    XP_016877877.1
    XP_016877878.1
    XP_024305737.1
    XP_024305738.1
    XP_047288731.1
    XP_047288732.1
    XP_047288733.1
    XP_047288734.1
    XP_054234305.1
    XP_054234306.1
    XP_054234307.1
    XP_054234308.1
    XP_054234309.1
    XP_054234310.1
    XP_054234311.1
    XP_054234312.1
    XP_054234313.1
    XP_054234314.1
    XP_054234315.1
    XP_054234316.1
    XP_054234317.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001316943.2 → NP_001303872.1  protein mono-ADP-ribosyltransferase PARP16 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice junction in the 3' end compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is 1 aa shorter compared to isoform 1.
      Source sequence(s)
      AC068213, AK000516, BC031074, DA110379
      Consensus CDS
      CCDS92018.1
      UniProtKB/Swiss-Prot
      A0A024R5Y7, Q6PK64, Q8N5Y8, Q9NX03
      Related
      ENSP00000496935.1, ENST00000649807.2
      Conserved Domains (2) summary
      pfam00644
      Location:95 → 273
      PARP; Poly(ADP-ribose) polymerase catalytic domain
      cl00283
      Location:150 → 259
      ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...

    2. NM_001316944.2 → NP_001303873.1  protein mono-ADP-ribosyltransferase PARP16 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks two alternate in-frame exons and uses an alternate in-frame splice junction at the 3' end compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AC068213, AK000516
      Consensus CDS
      CCDS81897.1
      UniProtKB/Swiss-Prot
      Q8N5Y8
      UniProtKB/TrEMBL
      A0A024R5Y7
      Related
      ENSP00000396118.2, ENST00000444347.2
      Conserved Domains (2) summary
      pfam00644
      Location:61 → 158
      PARP; Poly(ADP-ribose) polymerase catalytic domain
      pfam18084
      Location:11 → 64
      ARTD15_N; ARTD15 N-terminal domain

    3. NM_017851.6 → NP_060321.3  protein mono-ADP-ribosyltransferase PARP16 isoform 1

      See identical proteins and their annotated locations for NP_060321.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC068213, AK000516, BC006389, DA110379
      Consensus CDS
      CCDS10204.1
      UniProtKB/Swiss-Prot
      Q8N5Y8
      Related
      ENSP00000261888.6, ENST00000261888.10
      Conserved Domains (1) summary
      pfam00644
      Location:95 → 273
      PARP; Poly(ADP-ribose) polymerase catalytic domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      65230917..65286883 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047432777.1 → XP_047288733.1  protein mono-ADP-ribosyltransferase PARP16 isoform X7

    2. XM_047432778.1 → XP_047288734.1  protein mono-ADP-ribosyltransferase PARP16 isoform X13

    3. XM_006720590.4 → XP_006720653.1  protein mono-ADP-ribosyltransferase PARP16 isoform X2

      Conserved Domains (2) summary
      pfam00644
      Location:102 → 273
      PARP; Poly(ADP-ribose) polymerase catalytic domain
      pfam18084
      Location:11 → 90
      ARTD15_N; ARTD15 N-terminal domain

    4. XM_006720589.4 → XP_006720652.1  protein mono-ADP-ribosyltransferase PARP16 isoform X1

      Conserved Domains (2) summary
      pfam00644
      Location:102 → 273
      PARP; Poly(ADP-ribose) polymerase catalytic domain
      pfam18084
      Location:11 → 90
      ARTD15_N; ARTD15 N-terminal domain

    5. XM_047432775.1 → XP_047288731.1  protein mono-ADP-ribosyltransferase PARP16 isoform X3

    6. XM_047432776.1 → XP_047288732.1  protein mono-ADP-ribosyltransferase PARP16 isoform X4

    7. XM_024449969.2 → XP_024305737.1  protein mono-ADP-ribosyltransferase PARP16 isoform X10

      Conserved Domains (2) summary
      pfam00644
      Location:59 → 227
      PARP; Poly(ADP-ribose) polymerase catalytic domain
      pfam18084
      Location:11 → 66
      ARTD15_N; ARTD15 N-terminal domain

    8. XM_024449970.2 → XP_024305738.1  protein mono-ADP-ribosyltransferase PARP16 isoform X14

      Conserved Domains (2) summary
      pfam00644
      Location:108 → 204
      PARP; Poly(ADP-ribose) polymerase catalytic domain
      pfam18084
      Location:11 → 90
      ARTD15_N; ARTD15 N-terminal domain

    9. XM_017022387.3 → XP_016877876.1  protein mono-ADP-ribosyltransferase PARP16 isoform X9

      Conserved Domains (2) summary
      pfam00644
      Location:59 → 227
      PARP; Poly(ADP-ribose) polymerase catalytic domain
      pfam18084
      Location:11 → 65
      ARTD15_N; ARTD15 N-terminal domain

    10. XM_011521742.4 → XP_011520044.1  protein mono-ADP-ribosyltransferase PARP16 isoform X8

      Conserved Domains (2) summary
      pfam00644
      Location:59 → 227
      PARP; Poly(ADP-ribose) polymerase catalytic domain
      pfam18084
      Location:11 → 66
      ARTD15_N; ARTD15 N-terminal domain

    11. XM_017022386.3 → XP_016877875.1  protein mono-ADP-ribosyltransferase PARP16 isoform X6

      Conserved Domains (1) summary
      cl00283
      Location:131 → 240
      ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...

    12. XM_006720592.4 → XP_006720655.1  protein mono-ADP-ribosyltransferase PARP16 isoform X5

      See identical proteins and their annotated locations for XP_006720655.1

      Conserved Domains (2) summary
      pfam00644
      Location:86 → 254
      PARP; Poly(ADP-ribose) polymerase catalytic domain
      pfam18084
      Location:11 → 85
      ARTD15_N; ARTD15 N-terminal domain

    13. XM_017022389.3 → XP_016877878.1  protein mono-ADP-ribosyltransferase PARP16 isoform X12

      Conserved Domains (2) summary
      pfam00644
      Location:108 → 204
      PARP; Poly(ADP-ribose) polymerase catalytic domain
      pfam18084
      Location:11 → 90
      ARTD15_N; ARTD15 N-terminal domain

    14. XM_017022388.3 → XP_016877877.1  protein mono-ADP-ribosyltransferase PARP16 isoform X11

      Conserved Domains (2) summary
      pfam00644
      Location:108 → 204
      PARP; Poly(ADP-ribose) polymerase catalytic domain
      pfam18084
      Location:11 → 90
      ARTD15_N; ARTD15 N-terminal domain

    RNA

    1. XR_007064469.1 RNA Sequence

    2. XR_001751341.3 RNA Sequence

    3. XR_001751342.3 RNA Sequence

    4. XR_429460.4 RNA Sequence

    5. XR_429459.4 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      63040296..63096236 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054378335.1 → XP_054234310.1  protein mono-ADP-ribosyltransferase PARP16 isoform X7

    2. XM_054378341.1 → XP_054234316.1  protein mono-ADP-ribosyltransferase PARP16 isoform X13

    3. XM_054378331.1 → XP_054234306.1  protein mono-ADP-ribosyltransferase PARP16 isoform X2

    4. XM_054378330.1 → XP_054234305.1  protein mono-ADP-ribosyltransferase PARP16 isoform X1

    5. XM_054378332.1 → XP_054234307.1  protein mono-ADP-ribosyltransferase PARP16 isoform X4

    6. XM_054378338.1 → XP_054234313.1  protein mono-ADP-ribosyltransferase PARP16 isoform X10

    7. XM_054378342.1 → XP_054234317.1  protein mono-ADP-ribosyltransferase PARP16 isoform X14

    8. XM_054378337.1 → XP_054234312.1  protein mono-ADP-ribosyltransferase PARP16 isoform X9

    9. XM_054378336.1 → XP_054234311.1  protein mono-ADP-ribosyltransferase PARP16 isoform X8

    10. XM_054378334.1 → XP_054234309.1  protein mono-ADP-ribosyltransferase PARP16 isoform X6

    11. XM_054378333.1 → XP_054234308.1  protein mono-ADP-ribosyltransferase PARP16 isoform X5

    12. XM_054378340.1 → XP_054234315.1  protein mono-ADP-ribosyltransferase PARP16 isoform X12

    13. XM_054378339.1 → XP_054234314.1  protein mono-ADP-ribosyltransferase PARP16 isoform X11

    RNA

    1. XR_008488981.1 RNA Sequence

    2. XR_008488977.1 RNA Sequence

    3. XR_008488979.1 RNA Sequence

    4. XR_008488980.1 RNA Sequence

    5. XR_008488978.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8N5Y8.2 GenPept UniProtKB/Swiss-Prot:Q8N5Y8

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