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    LOC400499 putative uncharacterized protein LOC400499 [ Homo sapiens (human) ]

    Gene ID: 400499, updated on 10-Dec-2024

    Summary

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    Gene symbol
    LOC400499
    Gene description
    putative uncharacterized protein LOC400499
    See related
    Ensembl:ENSG00000188897
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    all
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    Genomic context

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    See LOC400499 in Genome Data Viewer
    Location:
    16p13.13
    Exon count:
    69
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (11372015..11527577, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (11408320..11563682, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (11465872..11621103, complement)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371082 Neighboring gene uncharacterized LOC105371083 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7202 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7203 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:11448108-11448960 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10438 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10439 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10440 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:11464582-11465082 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10441 Neighboring gene mitochondrial ribosomal protein L18 pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:11480804-11481686 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:11483724-11484478 Neighboring gene RecQ mediated genome instability 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:11507777-11508748 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10444 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:11550335-11550854 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:11550855-11551372 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10445 Neighboring gene uncharacterized LOC101927131 Neighboring gene uncharacterized LOC124903807 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:11564147-11564648 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:11588027-11589023 Neighboring gene Sharpr-MPRA regulatory region 8116 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:11592015-11592563 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:11595297-11596228 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:11610059-11610587 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:11612139-11612638 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:11620432-11621366 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:11621367-11622300 Neighboring gene OCT4-H3K4me1 hESC enhancer GRCh37_chr16:11637410-11638225 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:11654074-11654928 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:11656029-11656658 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:11657289-11657918 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:11657919-11658546 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:11665841-11666778 Neighboring gene Sharpr-MPRA regulatory region 2706 Neighboring gene lipopolysaccharide induced TNF factor Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10450 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7205 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7204 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:11688769-11689642 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:11689643-11690514 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:11697089-11697681 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:11699131-11699630 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10451 Neighboring gene Sharpr-MPRA regulatory region 4417 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:11708187-11708794 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:11708795-11709402 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:11715855-11716623 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:11720940-11721474 Neighboring gene uncharacterized LOC124903643 Neighboring gene Sharpr-MPRA regulatory region 8349

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome. Yao Z, et al. Mol Cell, 2017 Jan 19. PMID 28065597, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    General protein information

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    Preferred Names
    putative uncharacterized protein LOC400499

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001370704.1 → NP_001357633.1  putative uncharacterized protein LOC400499 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AC099489, KF573656
      Consensus CDS
      CCDS92108.1
      UniProtKB/TrEMBL
      A0A8Q3SIG1
      Related
      ENSP00000512464.1, ENST00000696174.1
      Conserved Domains (3) summary
      cl26969
      Location:50 → 585
      Vitellogenin_N; Lipoprotein amino terminal region
      pfam08742
      Location:3262 → 3308
      C8; C8 domain
      pfam09172
      Location:618 → 910
      DUF1943; Domain of unknown function (DUF1943)

    2. NM_001395505.1 → NP_001382434.1  putative uncharacterized protein LOC400499 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC099489, KF573656
      Consensus CDS
      CCDS92107.1
      UniProtKB/TrEMBL
      M0QZD8
      Related
      ENSP00000470478.3, ENST00000598234.6
      Conserved Domains (2) summary
      smart00832
      Location:3207 → 3253
      C8; This domain contains 8 conserved cysteine residues
      cl26969
      Location:50 → 585
      Vitellogenin_N; Lipoprotein amino terminal region

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      11372015..11527577 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017023946.1 → XP_016879435.1  putative uncharacterized protein LOC400499 isoform X1

    2. XM_047434105.1 → XP_047290061.1  putative uncharacterized protein LOC400499 isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      11408320..11563682 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054380319.1 → XP_054236294.1  putative uncharacterized protein LOC400499 isoform X1

    2. XM_054380320.1 → XP_054236295.1  putative uncharacterized protein LOC400499 isoform X2

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001013671.1: Suppressed sequence

      Description
      NM_001013671.1: This RefSeq record was removed by NCBI staff. Contact [email protected] for further information.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6ZTK2.1 GenPept UniProtKB/Swiss-Prot:Q6ZTK2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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