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    LNCRI lncRNA radiation induced regulator of PLK1 and RAD51 [ Homo sapiens (human) ]

    Gene ID: 401296, updated on 10-Dec-2024

    Summary

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    Official Symbol
    LNCRIprovided by HGNC
    Official Full Name
    lncRNA radiation induced regulator of PLK1 and RAD51provided by HGNC
    Primary source
    HGNC:HGNC:53790
    See related
    AllianceGenome:HGNC:53790
    Gene type
    ncRNA
    RefSeq status
    MODEL
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    lnc-RI
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

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    See LNCRI in Genome Data Viewer
    Location:
    7p22.3
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (1691906..1694350, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (1804468..1806912, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375303 Neighboring gene transcription factor A, mitochondrial pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:1688785-1689292 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:1708637-1709344 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:1709345-1710051 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:1710052-1710758 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:1710759-1711465 Neighboring gene extracellular leucine rich repeat and fibronectin type III domain containing 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:1744455-1745164 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:1745165-1745874 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:1748146-1748646 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:1748647-1749147 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:1752367-1753267 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:1753268-1754167 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:1756087-1756786 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:1756787-1757486 Neighboring gene uncharacterized LOC124901819 Neighboring gene uncharacterized LOC105375124 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:1764307-1764893

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Long noncoding RNA lnc-RI regulates DNA damage repair and radiation sensitivity of CRC cells through NHEJ pathway. Liu R, et al. Cell Biol Toxicol, 2020 Oct. PMID 32279126
    2. LncRNA lnc-RI regulates homologous recombination repair of DNA double-strand breaks by stabilizing RAD51 mRNA as a competitive endogenous RNA. Shen L, et al. Nucleic Acids Res, 2018 Jan 25. PMID 29216366, Free PMC Article
    3. Long noncoding RNA lnc-RI is a new regulator of mitosis via targeting miRNA-210-3p to release PLK1 mRNA activity. Wang ZD, et al. Sci Rep, 2016 May 10. PMID 27160062, Free PMC Article
    4. The palmitoyl acyltransferase HIP14 shares a high proportion of interactors with huntingtin: implications for a role in the pathogenesis of Huntington's disease. Butland SL, et al. Hum Mol Genet, 2014 Aug 1. PMID 24705354, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Long noncoding RNA lnc-RI regulates DNA damage repair and radiation sensitivity of CRC cells through NHEJ pathway.
      Title: Long noncoding RNA lnc-RI regulates DNA damage repair and radiation sensitivity of CRC cells through NHEJ pathway.
    2. The expression of RAD51 recombinase (RAD51), a key recombinase in the homologous recombination (HR) repair pathway, decreased sharply in long non-coding RNA lnc-RI-depressed cells.
      Title: LncRNA lnc-RI regulates homologous recombination repair of DNA double-strand breaks by stabilizing RAD51 mRNA as a competitive endogenous RNA.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Clone Names

    • AC074389.6, AC074389.7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      1691906..1694350 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_007060188.1 RNA Sequence

    2. XR_007060189.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      1804468..1806912 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_007078216.1 RNA Sequence

    2. XR_007078217.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001024677.1: Suppressed sequence

      Description
      NM_001024677.1: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
    Nucleotide Protein
    Heading Accession and Version

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