ndr2 nodal-related 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ndr2provided by ZNC
Official Full Name: nodal-related 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-990415-181
See related: Ensembl:ENSDARG00000101279 AllianceGenome:ZFIN:ZDB-GENE-990415-181
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cyc; ndr1; znr1; Ndr-2; Znr-1; cyclops
Summary: Predicted to enable cytokine activity. Acts upstream of or within several processes, including embryonic morphogenesis; nervous system development; and regionalization. Part of protein-containing complex. Is expressed in several structures, including axis; embryonic structure; forebrain; forebrain neural keel; and mesoderm. Human ortholog(s) of this gene implicated in visceral heterotaxy. Orthologous to human NODAL (nodal growth differentiation factor). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: chromosome: 12

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	12	NC_007123.7 (48204979..48212734)
105	previous assembly	GRCz10 (GCF_000002035.5)	12	NC_007123.6 (48295205..48302968)

Chromosome 12 - NC_007123.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The pattern of nodal morphogen signaling is shaped by co-receptor expression.
Title: The pattern of nodal morphogen signaling is shaped by co-receptor expression.
Zebrafish Cdx1b modulates epithalamic asymmetry by regulating ndr2 and lft1 expression.
Title: Zebrafish Cdx1b modulates epithalamic asymmetry by regulating ndr2 and lft1 expression.
Results indicate the structure-function of the nodal-related 2 protein (ndr2) gene.
Title: Analysis of novel domain-specific mutations in the zebrafish ndr2/cyclops gene generated using CRISPR-Cas9 RNPs.
Theauthors find that zebrafish lefty mutants exhibit excess Nodal signaling and increased specification of mesendoderm, resulting in embryonic lethality.
Title: Nodal patterning without Lefty inhibitory feedback is functional but fragile.
These results favour a model in which Apelin receptor is required to fine-tune Nodal output, acting as a specific rheostat for the Nodal/TGFbeta pathway during the earliest stages of cardiogenesis.
Title: The Apelin receptor enhances Nodal/TGFβ signaling to ensure proper cardiac development.
results indicate that differential diffusivity is the major determinant of the differences in Nodal/Lefty range and provide biophysical support for reaction-diffusion models of activator/inhibitor-mediated patterning
Title: Differential diffusivity of Nodal and Lefty underlies a reaction-diffusion patterning system.
This study identified a Nanog-like-Mxtx2-Nodal pathway and establishes a role for Nanog-like in regulating the formation of the extraembryonic tissue required for endoderm induction.
Title: Nanog-like regulates endoderm formation through the Mxtx2-Nodal pathway.
show that the co-disruption of extraembryonic Ndr2, extraembryonic Ndr1 and maternal Ndr1 eliminates endoderm and anterior (head and trunk) mesoderm, recapitulating the loss of Nodal signaling phenotype
Title: Embryonic mesoderm and endoderm induction requires the actions of non-embryonic Nodal-related ligands and Mxtx2.
characterize the zebrafish Nodal-related factor Cyclops (Cyc) and find unexpected functions for the pro-domain in regulating Cyc activity
Title: The pro-domain of the zebrafish Nodal-related protein Cyclops regulates its signaling activities.
the zebrafish Nodal-related proteins Squint and Cyclops are required in the YSL for endoderm and head mesoderm formation.
Title: Nodal signals mediate interactions between the extra-embryonic and embryonic tissues in zebrafish.

Submit: New GeneRIF Correction See all GeneRIFs (15)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables growth factor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Spemann organizer formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within animal organ morphogenesis	IMP Inferred from Mutant Phenotype more info
acts_upstream_of_or_within anterior/posterior pattern specification	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within brain morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell fate commitment	IGI Inferred from Genetic Interaction more info
acts_upstream_of_or_within cell fate determination	IMP Inferred from Mutant Phenotype more info
acts_upstream_of_or_within determination of left/right symmetry	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within dorsal/ventral pattern formation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within dorsal/ventral pattern formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic eye morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic heart tube morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within floor plate development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within floor plate formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart looping	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hypothalamus development	IMP Inferred from Mutant Phenotype more info
acts_upstream_of_or_within inner ear development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within lens placode formation involved in camera-type eye formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mesendoderm development	IMP Inferred from Mutant Phenotype more info
acts_upstream_of_or_within mesoderm formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within notochord development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within notochord formation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within protein processing	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of protein secretion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of BMP signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within retina development in camera-type eye	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within retinal ganglion cell axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within telencephalon development	IMP Inferred from Mutant Phenotype more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
part_of protein-containing complex	IPI Inferred from Physical Interaction more info	PubMed

General protein information

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Preferred Names: nodal-related 2

Names: cyc-1; nodal-related 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_139133.1 → NP_624359.1 nodal-related 2 precursor

See identical proteins and their annotated locations for NP_624359.1

Status: PROVISIONAL

Source sequence(s)

AF002219

UniProtKB/TrEMBL

P87358, Q9PSU9

Related

ENSDARP00000157283.1, ENSDART00000190534.1

Conserved Domains (3) summary

pfam00019
Location:401 → 500

TGF_beta; Transforming growth factor beta like domain

pfam00688
Location:44 → 174

TGFb_propeptide; TGF-beta propeptide

pfam07793
Location:175 → 277

DUF1631; Protein of unknown function (DUF1631)