grem2b gremlin 2, DAN family BMP antagonist b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: grem2bprovided by ZNC
Official Full Name: gremlin 2, DAN family BMP antagonist bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030911-9
See related: Ensembl:ENSDARG00000103092 AllianceGenome:ZFIN:ZDB-GENE-030911-9
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: prdc; grem2; zgc:112207
Summary: Predicted to enable cytokine activity. Acts upstream of or within BMP signaling pathway; cartilage morphogenesis; and heart development. Predicted to be located in extracellular space. Is expressed in several structures, including digestive system; head; optic cup; optic vesicle; and swim bladder bud. Human ortholog(s) of this gene implicated in tooth agenesis. Orthologous to human GREM2 (gremlin 2, DAN family BMP antagonist). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 12

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	12	NC_007123.7 (47543832..47558276, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	12	NC_007123.6 (47544633..47560549, complement)

Chromosome 12 - NC_007123.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Through regulation of bone morphogenetic protein signaling, GREM2 is required for cardiac laterality and atrial differentiation during embryonic development.
Title: Functional modeling in zebrafish demonstrates that the atrial-fibrillation-associated gene GREM2 regulates cardiac laterality, cardiomyocyte differentiation and atrial rhythm.
Gremlin 2 regulates distinct roles of BMP and Endothelin 1 signaling in dorsoventral patterning of the facial skeleton.
Title: Gremlin 2 regulates distinct roles of BMP and Endothelin 1 signaling in dorsoventral patterning of the facial skeleton.
Prdc is expressed in the developing eyes and the first two pharyngeal arches, in the outer layers of the optic cup, in the arch mesenchyme expands stepwise to the remaining posterior arches, and in the somites and the the swim bladder.
Title: Expression of the protein related to Dan and Cerberus gene--prdc--During eye, pharyngeal arch, somite, and swim bladder development in zebrafish.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

NoName (e-PCR)
- UniSTS:238350

Z3467 (e-PCR)
- UniSTS:10475

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables cytokine activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within BMP signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cardiac atrium development	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cardiac atrium development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cardiac chamber development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cartilage development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cartilage morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell surface receptor signaling pathway involved in heart development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: gremlin-2b

Names: gremlin 2, cysteine knot superfamily; protein related to DAN and cerberus homolog

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.