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    MIR570HG MIR570 host gene [ Homo sapiens (human) ]

    Gene ID: 440993, updated on 17-Sep-2024

    Summary

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    Official Symbol
    MIR570HGprovided by HGNC
    Official Full Name
    MIR570 host geneprovided by HGNC
    Primary source
    HGNC:HGNC:53743
    See related
    AllianceGenome:HGNC:53743
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LINC00969
    Expression
    Ubiquitous expression in testis (RPKM 6.0), small intestine (RPKM 5.6) and 25 other tissues See more
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    Genomic context

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    See MIR570HG in Genome Data Viewer
    Location:
    3q29
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (195688498..195711875)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (198397911..198407978)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (195415369..195438746)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene ReSE screen-validated silencer GRCh37_chr3:195345772-195345926 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:195350846-195351842 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:195354448-195355072 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:195355073-195355695 Neighboring gene mucin 20, cell surface associated pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:195359633-195360132 Neighboring gene uncharacterized LOC105374297 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:195373516-195374016 Neighboring gene serine/threonine-protein phosphatase 4 regulatory subunit 2-like Neighboring gene SDHA pseudogene 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:195408429-195408928 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:195410251-195410972 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:195410973-195411692 Neighboring gene uncharacterized LOC124909477 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr3:195431923-195432494 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:195437307-195437978 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:195437979-195438649 Neighboring gene microRNA 570 Neighboring gene somatomedin B domain containing 1, pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:195453109-195453610 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:195461991-195462491 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:195466177-195466985 Neighboring gene mucin 20, cell surface associated Neighboring gene ReSE screen-validated silencer GRCh37_chr3:195474413-195474579 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:195489021-195489522 Neighboring gene mucin 4, cell surface associated Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:195495435-195495936 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr3:195505212-195506411 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:195508163-195508662 Neighboring gene Sharpr-MPRA regulatory region 430 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:195533677-195534240 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:195535933-195536496 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:195536497-195537060

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Exosomal Linc00969 induces trastuzumab resistance in breast cancer by increasing HER-2 protein expression and mRNA stability by binding to HUR. Liu C, et al. Breast Cancer Res, 2023 Oct 17. PMID 37848981, Free PMC Article
    2. LINC00969 promotes the degeneration of intervertebral disk by sponging miR-335-3p and regulating NLRP3 inflammasome activation. Yu L, et al. IUBMB Life, 2019 May. PMID 30592131
    3. Identification of long noncoding RNAs for the detection of early stage lung squamous cell carcinoma by microarray analysis. Cheng Z, et al. Oncotarget, 2017 Feb 21. PMID 28076325, Free PMC Article
    4. Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism. Corominas R, et al. Nat Commun, 2014 Apr 11. PMID 24722188, Free PMC Article
    5. Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. Dias Neto E, et al. Proc Natl Acad Sci U S A, 2000 Mar 28. PMID 10737800, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Exosomal Linc00969 induces trastuzumab resistance in breast cancer by increasing HER-2 protein expression and mRNA stability by binding to HUR.
      Title: Exosomal Linc00969 induces trastuzumab resistance in breast cancer by increasing HER-2 protein expression and mRNA stability by binding to HUR.
    2. High LINC00969 expression is associated with degeneration of intervertebral disk.
      Title: LINC00969 promotes the degeneration of intervertebral disk by sponging miR-335-3p and regulating NLRP3 inflammasome activation.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Other Names

    • long intergenic non-protein coding RNA 969

    Clone Names

    • AC069513.3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_122105.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC233280

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      195688498..195711875
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NT_187532.1 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      58995..82372
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_2

    Genomic

    1. NT_187649.1 Reference GRCh38.p14 ALT_REF_LOCI_2

      Range
      81285..103902 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_3

    Genomic

    1. NT_187678.1 Reference GRCh38.p14 ALT_REF_LOCI_3

      Range
      84169..107546 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_4

    Genomic

    1. NT_187688.1 Reference GRCh38.p14 ALT_REF_LOCI_4

      Range
      81492..104464 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_5

    Genomic

    1. NT_187689.1 Reference GRCh38.p14 ALT_REF_LOCI_5

      Range
      58995..82372
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_6

    Genomic

    1. NT_187690.1 Reference GRCh38.p14 ALT_REF_LOCI_6

      Range
      81799..105176 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_7

    Genomic

    1. NT_187691.1 Reference GRCh38.p14 ALT_REF_LOCI_7

      Range
      82066..106613 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      198397911..198407978
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001013714.1: Suppressed sequence

      Description
      NM_001013714.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.