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    UQCRC1 ubiquinol-cytochrome c reductase core protein 1 [ Homo sapiens (human) ]

    Gene ID: 7384, updated on 10-Dec-2024

    Summary

    Official Symbol
    UQCRC1provided by HGNC
    Official Full Name
    ubiquinol-cytochrome c reductase core protein 1provided by HGNC
    Primary source
    HGNC:HGNC:12585
    See related
    Ensembl:ENSG00000010256 MIM:191328; AllianceGenome:HGNC:12585
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    QCR1; PKNPY; UQCR1; D3S3191
    Summary
    Enables ubiquitin protein ligase binding activity. Predicted to be involved in oxidative phosphorylation. Predicted to act upstream of or within mitochondrial electron transport, ubiquinol to cytochrome c. Located in mitochondrion. Part of mitochondrial inner membrane. Implicated in Alzheimer's disease. Biomarker of Alzheimer's disease. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in heart (RPKM 170.6), kidney (RPKM 96.0) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See UQCRC1 in Genome Data Viewer
    Location:
    3p21.31
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (48599002..48609646, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (48627962..48639898, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (48636435..48647079, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:48605535-48606482 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:48607079-48607628 Neighboring gene collagen type VII alpha 1 chain Neighboring gene urocortin 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:48625763-48626466 Neighboring gene microRNA 711 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:48626467-48627168 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:48638465-48638965 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14334 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19838 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:48647149-48647663 Neighboring gene small nucleolar RNA, H/ACA box 94 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:48651179-48651678 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:48666910-48667410 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:48667411-48667911 Neighboring gene transmembrane protein 89 Neighboring gene solute carrier family 26 member 6 Neighboring gene microRNA 6824

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of ubiquinol-cytochrome c reductase core protein I (UQCRC1) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-containing complex binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquinol-cytochrome-c reductase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in aerobic respiration TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in cellular respiration NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in mitochondrial electron transport, ubiquinol to cytochrome c NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in oxidative phosphorylation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to activity IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to alkaloid IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrial inner membrane TAS
    Traceable Author Statement
    more info
     
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion HTP PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
     
    part_of respiratory chain complex TAS
    Traceable Author Statement
    more info
    PubMed 
    part_of respiratory chain complex III IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    cytochrome b-c1 complex subunit 1, mitochondrial
    Names
    complex III subunit 1
    core protein I
    ubiquinol-cytochrome c reductase core protein I
    ubiquinol-cytochrome-c reductase complex core protein 1
    NP_003356.2
    XP_054203719.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_003365.3NP_003356.2  cytochrome b-c1 complex subunit 1, mitochondrial precursor

      See identical proteins and their annotated locations for NP_003356.2

      Status: VALIDATED

      Source sequence(s)
      AA284910, AK129903, L16842
      Consensus CDS
      CCDS2774.1
      UniProtKB/Swiss-Prot
      B2R7R8, P31930, Q96DD2
      UniProtKB/TrEMBL
      A0AAQ5BHN1
      Related
      ENSP00000203407.5, ENST00000203407.6
      Conserved Domains (1) summary
      COG0612
      Location:41469
      PqqL; Predicted Zn-dependent peptidase [General function prediction only]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      48599002..48609646 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      48627962..48639898 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054347744.1XP_054203719.1  cytochrome b-c1 complex subunit 1, mitochondrial isoform X1

      UniProtKB/Swiss-Prot
      B2R7R8, P31930, Q96DD2
      UniProtKB/TrEMBL
      A0AAQ5BHN1