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    SLC41A2 solute carrier family 41 member 2 [ Homo sapiens (human) ]

    Gene ID: 84102, updated on 27-Nov-2024

    Summary

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    Official Symbol
    SLC41A2provided by HGNC
    Official Full Name
    solute carrier family 41 member 2provided by HGNC
    Primary source
    HGNC:HGNC:31045
    See related
    Ensembl:ENSG00000136052 MIM:610802; AllianceGenome:HGNC:31045
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SLC41A1-L1
    Summary
    Predicted to enable magnesium ion transmembrane transporter activity. Involved in magnesium ion transport. Located in plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in liver (RPKM 11.3), duodenum (RPKM 5.8) and 20 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See SLC41A2 in Genome Data Viewer
    Location:
    12q23.3
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (104801801..104958746, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (104763412..104920359, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (105195579..105352524, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene carbohydrate sulfotransferase 11 Neighboring gene ATP synthase F(0) complex subunit C1, mitochondrial-like Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6921 Neighboring gene Sharpr-MPRA regulatory region 14866 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr12:104920569-104921159 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6922 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:104949096-104949598 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:104950760-104951594 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_23947 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6923 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6924 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6925 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6926 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6927 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:104997281-104997908 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:104997909-104998535 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:104998957-104999544 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:104999545-105000132 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr12:105017531-105018268 Neighboring gene microRNA 3922 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:105026139-105026640 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6928 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6929 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:105065189-105065793 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:105081721-105081916 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6930 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6931 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:105102028-105102832 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:105102833-105103637 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6932 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:105114284-105114912 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:105116877-105117495 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6934 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:105136527-105137148 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr12:105144840-105145417 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6935 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6936 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_24027 Neighboring gene Sharpr-MPRA regulatory region 12146 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6937 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_24038 Neighboring gene Sharpr-MPRA regulatory region 3023 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6938 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4799 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4800 Neighboring gene uncharacterized LOC105369952 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:105379748-105380260 Neighboring gene keratin 18 pseudogene 20 Neighboring gene NOP protein chaperone 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. SLC41A2 encodes a plasma-membrane Mg2+ transporter. Sahni J, et al. Biochem J, 2007 Jan 15. PMID 16984228, Free PMC Article
    2. Functional characterization of the mouse [corrected] solute carrier, SLC41A2. Goytain A, et al. Biochem Biophys Res Commun, 2005 May 13. PMID 15809054
    3. The human solute carrier SLC41A1 belongs to a novel eukaryotic subfamily with homology to prokaryotic MgtE Mg2+ transporters. Wabakken T, et al. Biochem Biophys Res Commun, 2003 Jul 4. PMID 12810078
    4. Systematic identification of pathological lamin A interactors. Dittmer TA, et al. Mol Biol Cell, 2014 May. PMID 24623722, Free PMC Article
    5. Estrogen-regulated feedback loop limits the efficacy of estrogen receptor-targeted breast cancer therapy. Xiao T, et al. Proc Natl Acad Sci U S A, 2018 Jul 31. PMID 29987050, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC125330, MGC125331, DKFZp434K0427

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables magnesium ion transmembrane transporter activity TAS
    Traceable Author Statement
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cobalt ion transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in iron ion transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in magnesium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in magnesium ion transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in manganese ion transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in nickel cation transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    solute carrier family 41 member 2
    Names
    SLC41A1-like 1
    solute carrier family 41 (magnesium transporter), member 2

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001352169.2 → NP_001339098.1  solute carrier family 41 member 2 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-8 all encode the same isoform (a).
      Source sequence(s)
      AC089985, AC090051
      Consensus CDS
      CCDS9100.2
      UniProtKB/Swiss-Prot
      Q3KP68, Q96JW4, Q9H0E5
      Conserved Domains (1) summary
      pfam01769
      Location:414 → 555
      MgtE; Divalent cation transporter

    2. NM_001352170.3 → NP_001339099.1  solute carrier family 41 member 2 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-8 all encode the same isoform (a).
      Source sequence(s)
      AC089985, AC090051
      Consensus CDS
      CCDS9100.2
      UniProtKB/Swiss-Prot
      Q3KP68, Q96JW4, Q9H0E5
      Conserved Domains (1) summary
      pfam01769
      Location:414 → 555
      MgtE; Divalent cation transporter

    3. NM_001352171.3 → NP_001339100.1  solute carrier family 41 member 2 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1-8 all encode the same isoform (a).
      Source sequence(s)
      AC089985, AC090051
      Consensus CDS
      CCDS9100.2
      UniProtKB/Swiss-Prot
      Q3KP68, Q96JW4, Q9H0E5
      Related
      ENSP00000258538.3, ENST00000258538.8
      Conserved Domains (1) summary
      pfam01769
      Location:414 → 555
      MgtE; Divalent cation transporter

    4. NM_001352172.3 → NP_001339101.1  solute carrier family 41 member 2 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1-8 all encode the same isoform (a).
      Source sequence(s)
      AC089985, AC090051
      Consensus CDS
      CCDS9100.2
      UniProtKB/Swiss-Prot
      Q3KP68, Q96JW4, Q9H0E5
      Conserved Domains (1) summary
      pfam01769
      Location:414 → 555
      MgtE; Divalent cation transporter

    5. NM_001387125.1 → NP_001374054.1  solute carrier family 41 member 2 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. Variants 1-8 all encode the same isoform (a).
      Source sequence(s)
      AC089985, AC090051
      Consensus CDS
      CCDS9100.2
      UniProtKB/Swiss-Prot
      Q3KP68, Q96JW4, Q9H0E5
      Conserved Domains (1) summary
      pfam01769
      Location:414 → 555
      MgtE; Divalent cation transporter

    6. NM_001387126.1 → NP_001374055.1  solute carrier family 41 member 2 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 1. Variants 1-8 all encode the same isoform (a).
      Source sequence(s)
      AC089985, AC090051
      Consensus CDS
      CCDS9100.2
      UniProtKB/Swiss-Prot
      Q3KP68, Q96JW4, Q9H0E5
      Conserved Domains (1) summary
      pfam01769
      Location:414 → 555
      MgtE; Divalent cation transporter

    7. NM_001387127.1 → NP_001374056.1  solute carrier family 41 member 2 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) differs in the 5' UTR compared to variant 1. Variants 1-8 all encode the same isoform (a).
      Source sequence(s)
      AC089985, AC090051
      Consensus CDS
      CCDS9100.2
      UniProtKB/Swiss-Prot
      Q3KP68, Q96JW4, Q9H0E5
      Conserved Domains (1) summary
      pfam01769
      Location:414 → 555
      MgtE; Divalent cation transporter

    8. NM_001387128.1 → NP_001374057.1  solute carrier family 41 member 2 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (9), as well as variants 10 and 11, encodes isoform b.
      Source sequence(s)
      AC089985, AC090051
      Conserved Domains (1) summary
      pfam01769
      Location:200 → 332
      MgtE; Divalent cation transporter

    9. NM_001387129.1 → NP_001374058.1  solute carrier family 41 member 2 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (10), as well as variants 9 and 11, encodes isoform b.
      Source sequence(s)
      AC089985, AC090051
      Conserved Domains (1) summary
      pfam01769
      Location:200 → 332
      MgtE; Divalent cation transporter

    10. NM_001387130.1 → NP_001374059.1  solute carrier family 41 member 2 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (11), as well as variants 9 and 10, encodes isoform b.
      Source sequence(s)
      AC089985, AC090051
      Conserved Domains (1) summary
      pfam01769
      Location:200 → 332
      MgtE; Divalent cation transporter

    11. NM_001387131.1 → NP_001374060.1  solute carrier family 41 member 2 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (12), as well as variants 13 and 14, encodes isoform c.
      Source sequence(s)
      AC089985, AC090051
      Conserved Domains (1) summary
      pfam01769
      Location:200 → 332
      MgtE; Divalent cation transporter

    12. NM_001387132.1 → NP_001374061.1  solute carrier family 41 member 2 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (13), as well as variants 12 and 14, encodes isoform c.
      Source sequence(s)
      AC089985, AC090051
      Conserved Domains (1) summary
      pfam01769
      Location:200 → 332
      MgtE; Divalent cation transporter

    13. NM_001387133.1 → NP_001374062.1  solute carrier family 41 member 2 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (14), as well as variants 12 and 13, encodes isoform c.
      Source sequence(s)
      AC089985, AC090051
      Conserved Domains (1) summary
      pfam01769
      Location:200 → 332
      MgtE; Divalent cation transporter

    14. NM_032148.6 → NP_115524.3  solute carrier family 41 member 2 isoform a

      See identical proteins and their annotated locations for NP_115524.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Variants 1-8 all encode the same isoform (a).
      Source sequence(s)
      AC089985, AC090051
      Consensus CDS
      CCDS9100.2
      UniProtKB/Swiss-Prot
      Q3KP68, Q96JW4, Q9H0E5
      Conserved Domains (1) summary
      pfam01769
      Location:414 → 555
      MgtE; Divalent cation transporter

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      104801801..104958746 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047429648.1 → XP_047285604.1  solute carrier family 41 member 2 isoform X1

      UniProtKB/Swiss-Prot
      Q3KP68, Q96JW4, Q9H0E5

    2. XM_017020013.2 → XP_016875502.1  solute carrier family 41 member 2 isoform X1

      UniProtKB/Swiss-Prot
      Q3KP68, Q96JW4, Q9H0E5
      Conserved Domains (1) summary
      pfam01769
      Location:414 → 555
      MgtE; Divalent cation transporter

    3. XM_005269179.2 → XP_005269236.1  solute carrier family 41 member 2 isoform X1

      See identical proteins and their annotated locations for XP_005269236.1

      UniProtKB/Swiss-Prot
      Q3KP68, Q96JW4, Q9H0E5
      Conserved Domains (1) summary
      pfam01769
      Location:414 → 555
      MgtE; Divalent cation transporter

    4. XM_011538811.3 → XP_011537113.1  solute carrier family 41 member 2 isoform X1

      See identical proteins and their annotated locations for XP_011537113.1

      UniProtKB/Swiss-Prot
      Q3KP68, Q96JW4, Q9H0E5
      Conserved Domains (1) summary
      pfam01769
      Location:414 → 555
      MgtE; Divalent cation transporter

    5. XM_017020016.3 → XP_016875505.1  solute carrier family 41 member 2 isoform X4

    6. XM_011538813.3 → XP_011537115.1  solute carrier family 41 member 2 isoform X5

      Conserved Domains (1) summary
      pfam01769
      Location:188 → 328
      MgtE; Divalent cation transporter

    7. XM_047429649.1 → XP_047285605.1  solute carrier family 41 member 2 isoform X2

    8. XM_047429650.1 → XP_047285606.1  solute carrier family 41 member 2 isoform X3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      104763412..104920359 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054373422.1 → XP_054229397.1  solute carrier family 41 member 2 isoform X1

      UniProtKB/Swiss-Prot
      Q3KP68, Q96JW4, Q9H0E5

    2. XM_054373423.1 → XP_054229398.1  solute carrier family 41 member 2 isoform X1

      UniProtKB/Swiss-Prot
      Q3KP68, Q96JW4, Q9H0E5

    3. XM_054373424.1 → XP_054229399.1  solute carrier family 41 member 2 isoform X1

      UniProtKB/Swiss-Prot
      Q3KP68, Q96JW4, Q9H0E5

    4. XM_054373425.1 → XP_054229400.1  solute carrier family 41 member 2 isoform X1

      UniProtKB/Swiss-Prot
      Q3KP68, Q96JW4, Q9H0E5

    5. XM_054373428.1 → XP_054229403.1  solute carrier family 41 member 2 isoform X4

    6. XM_054373430.1 → XP_054229405.1  solute carrier family 41 member 2 isoform X5

    7. XM_054373429.1 → XP_054229404.1  solute carrier family 41 member 2 isoform X6

    8. XM_054373426.1 → XP_054229401.1  solute carrier family 41 member 2 isoform X2

    9. XM_054373427.1 → XP_054229402.1  solute carrier family 41 member 2 isoform X3

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96JW4.2 GenPept UniProtKB/Swiss-Prot:Q96JW4

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