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    Mro maestro [ Mus musculus (house mouse) ]

    Gene ID: 71263, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mroprovided by MGI
    Official Full Name
    maestroprovided by MGI
    Primary source
    MGI:MGI:2152817
    See related
    Ensembl:ENSMUSG00000064036 AllianceGenome:MGI:2152817
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4930507C04Rik; 4933435E20Rik
    Summary
    Located in nucleolus. Is expressed in reproductive system. Orthologous to human MRO (maestro). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis adult (RPKM 3.0), ovary adult (RPKM 2.7) and 11 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mro in Genome Data Viewer
    Location:
    18 E2; 18 50.21 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (73992465..74014405)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (73851826..73881334)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene malic enzyme 2, NAD(+)-dependent, mitochondrial Neighboring gene STARR-positive B cell enhancer ABC_E11003 Neighboring gene STARR-seq mESC enhancer starr_44997 Neighboring gene predicted gene, 52346 Neighboring gene predicted gene, 32661 Neighboring gene mitogen-activated protein kinase 4 Neighboring gene RIKEN cDNA D730045A05 gene Neighboring gene STARR-seq mESC enhancer starr_45000 Neighboring gene predicted gene 9925

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Candidate testis-determining gene, Maestro (Mro), encodes a novel HEAT repeat protein. Smith L, et al. Dev Dyn, 2003 Aug. PMID 12889070
    2. The Maestro (Mro) gene is dispensable for normal sexual development and fertility in mice. Smith L, et al. PLoS One, 2008. PMID 19116663, Free PMC Article
    3. A gene-driven ENU-based approach to generating an allelic series in any gene. Quwailid MM, et al. Mamm Genome, 2004 Aug. PMID 15457338
    4. Using real time RT-PCR analysis to determine multiple gene expression patterns during XX and XY mouse fetal gonad development. Bouma GJ, et al. Gene Expr Patterns, 2004 Nov. PMID 15533830
    5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Maestro is dispensable for normal male sexual development and fertility in laboratory mice
      Title: The Maestro (Mro) gene is dispensable for normal sexual development and fertility in mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein maestro
    Names
    male-specific transcription in the developing reproductive organs

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001305882.2 → NP_001292811.1  protein maestro isoform 1

      See identical proteins and their annotated locations for NP_001292811.1

      Status: VALIDATED

      Source sequence(s)
      AC124367
      Consensus CDS
      CCDS79663.1
      UniProtKB/Swiss-Prot
      Q7TNB4, Q9D3T8
      UniProtKB/TrEMBL
      E9QNX2
      Related
      ENSMUSP00000113434.2, ENSMUST00000120033.8
      Conserved Domains (1) summary
      sd00044
      Location:46 → 74
      HEAT; HEAT repeat [structural motif]

    2. NM_001360973.2 → NP_001347902.1  protein maestro isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC124367
      Conserved Domains (1) summary
      sd00044
      Location:183 → 211
      HEAT; HEAT repeat [structural motif]

    3. NM_001403901.1 → NP_001390830.1  protein maestro isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC124367

    4. NM_001403902.1 → NP_001390831.1  protein maestro isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC124367

    5. NM_001403903.1 → NP_001390832.1  protein maestro isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC124367

    6. NM_001403904.1 → NP_001390833.1  protein maestro isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC124367

    7. NM_001403905.1 → NP_001390834.1  protein maestro isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC124367

    8. NM_001403906.1 → NP_001390835.1  protein maestro isoform 10

      Status: VALIDATED

      Source sequence(s)
      AC124367

    9. NM_001403907.1 → NP_001390836.1  protein maestro isoform 11

      Status: VALIDATED

      Source sequence(s)
      AC124367

    10. NM_001403908.1 → NP_001390837.1  protein maestro isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC124367
      UniProtKB/Swiss-Prot
      Q7TNB4, Q9D3T8
      UniProtKB/TrEMBL
      E9QNX2
      Related
      ENSMUSP00000136775.2, ENSMUST00000179472.8

    11. NM_001403909.1 → NP_001390838.1  protein maestro isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC124367
      UniProtKB/Swiss-Prot
      Q7TNB4, Q9D3T8
      UniProtKB/TrEMBL
      E9PUF9

    12. NM_001403910.1 → NP_001390839.1  protein maestro isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC124367

    13. NM_001403911.1 → NP_001390840.1  protein maestro isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC124367

    14. NM_027741.4 → NP_082017.2  protein maestro isoform 2

      See identical proteins and their annotated locations for NP_082017.2

      Status: VALIDATED

      Source sequence(s)
      AC124367
      Consensus CDS
      CCDS50319.1
      UniProtKB/Swiss-Prot
      Q7TNB4, Q9D3T8
      UniProtKB/TrEMBL
      E9PUF9
      Related
      ENSMUSP00000113392.2, ENSMUST00000119239.8
      Conserved Domains (1) summary
      sd00044
      Location:46 → 74
      HEAT; HEAT repeat [structural motif]

    RNA

    1. NR_175778.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC124367

    2. NR_175779.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC124367

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      73992465..74014405
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036161280.1 → XP_036017173.1  protein maestro isoform X13

    2. XM_017317980.3 → XP_017173469.1  protein maestro isoform X6

    3. XM_036161278.1 → XP_036017171.1  protein maestro isoform X3

      Conserved Domains (1) summary
      sd00044
      Location:183 → 211
      HEAT; HEAT repeat [structural motif]

    4. XM_030250600.2 → XP_030106460.1  protein maestro isoform X12

      UniProtKB/Swiss-Prot
      Q7TNB4, Q9D3T8
      UniProtKB/TrEMBL
      E9PUF9
      Conserved Domains (1) summary
      sd00044
      Location:46 → 74
      HEAT; HEAT repeat [structural motif]

    5. XM_030250599.2 → XP_030106459.1  protein maestro isoform X11

      UniProtKB/Swiss-Prot
      Q7TNB4, Q9D3T8
      UniProtKB/TrEMBL
      E9QNX2
      Conserved Domains (1) summary
      sd00044
      Location:46 → 74
      HEAT; HEAT repeat [structural motif]

    6. XM_006526251.5 → XP_006526314.1  protein maestro isoform X4

      Conserved Domains (1) summary
      sd00044
      Location:176 → 208
      HEAT; HEAT repeat [structural motif]

    7. XM_006526260.5 → XP_006526323.1  protein maestro isoform X11

      See identical proteins and their annotated locations for XP_006526323.1

      UniProtKB/Swiss-Prot
      Q7TNB4, Q9D3T8
      UniProtKB/TrEMBL
      E9QNX2
      Conserved Domains (1) summary
      sd00044
      Location:46 → 74
      HEAT; HEAT repeat [structural motif]

    8. XM_036161282.1 → XP_036017175.1  protein maestro isoform X18

      Conserved Domains (1) summary
      sd00044
      Location:9 → 41
      HEAT; HEAT repeat [structural motif]

    9. XM_036161283.1 → XP_036017176.1  protein maestro isoform X18

      Conserved Domains (1) summary
      sd00044
      Location:9 → 41
      HEAT; HEAT repeat [structural motif]

    RNA

    1. XR_003952542.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7TNB4.1 GenPept UniProtKB/Swiss-Prot:Q7TNB4

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