Alpk1 alpha-kinase 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Alpk1provided by MGI
Official Full Name: alpha-kinase 1provided by MGI
Primary source: MGI:MGI:1918731
See related: Ensembl:ENSMUSG00000028028 AllianceGenome:MGI:1918731
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: LAK; 8430410J10Rik
Summary: Predicted to enable monosaccharide binding activity and protein serine/threonine kinase activity. Involved in cytoplasmic pattern recognition receptor signaling pathway and innate immune response. Acts upstream of or within response to bacterium. Located in photoreceptor connecting cilium. Orthologous to human ALPK1 (alpha kinase 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in bladder adult (RPKM 6.6), large intestine adult (RPKM 3.3) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 G2; 3 56.54 cM

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (127460367..127574195, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (127666718..127780547, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The relationship of ALPK1, hyaluronic acid and M1 macrophage polarization in the temporomandibular joint synovitis.
Title: The relationship of ALPK1, hyaluronic acid and M1 macrophage polarization in the temporomandibular joint synovitis.
Alpha-kinase1 promotes tubular injury and interstitial inflammation in diabetic nephropathy by canonical pyroptosis pathway.
Title: Alpha-kinase1 promotes tubular injury and interstitial inflammation in diabetic nephropathy by canonical pyroptosis pathway.
Neuroprotective effect of alpha-kinase 1 knockdown against cerebral ischemia through inhibition of the NF-kappaB pathway and neuroinflammation.
Title: Neuroprotective effect of alpha-kinase 1 knockdown against cerebral ischemia through inhibition of the NF-κB pathway and neuroinflammation.
ALPK1 Accelerates the Pathogenesis of Osteoarthritis by Activating NLRP3 Signaling.
Title: ALPK1 Accelerates the Pathogenesis of Osteoarthritis by Activating NLRP3 Signaling.
Gain-of-function mutations in ALPK1 cause an NF-kappaB-mediated autoinflammatory disease: functional assessment, clinical phenotyping and disease course of patients with ROSAH syndrome.
Title: Gain-of-function mutations in ALPK1 cause an NF-κB-mediated autoinflammatory disease: functional assessment, clinical phenotyping and disease course of patients with ROSAH syndrome.
Alpk1 Sensitizes Pancreatic Beta Cells to Cytokine-Induced Apoptosis via Upregulating TNF-alpha Signaling Pathway.
Title: Alpk1 Sensitizes Pancreatic Beta Cells to Cytokine-Induced Apoptosis via Upregulating TNF-α Signaling Pathway.
findings identify ALPK1 and ADP-beta-D-manno-heptose as a pattern recognition receptor and an effective immunomodulator, respectively
Title: Alpha-kinase 1 is a cytosolic innate immune receptor for bacterial ADP-heptose.
Study demonstrates that Alpk1 promotes intestinal homoeostasis by regulating the balance of type 1/type 17 immunity following microbial challenge.
Title: Alpha kinase 1 controls intestinal inflammation by suppressing the IL-12/Th1 axis.
data suggests that the balance between ALPK1 and testosterone plays a critical role in the testosterone-mediated inhibition of proinflammatory cytokines
Title: ALPK1 affects testosterone mediated regulation of proinflammatory cytokines production.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (7) 1 citation
Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-152347 (e-PCR)
- UniSTS:177482

D3Mit109 (e-PCR), detects polymorphism
- UniSTS:129511

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 3-phosphoinositide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS121 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS139 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS14 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS36 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S28 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S57 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H4S1 kinase activity	IEA Inferred from Electronic Annotation more info
enables monosaccharide binding	IBA Inferred from Biological aspect of Ancestor more info
enables monosaccharide binding	ISO Inferred from Sequence Orthology more info
enables monosaccharide binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables ribosomal protein S6 kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in cilium assembly	ISO Inferred from Sequence Orthology more info
involved_in cilium assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in cytoplasmic pattern recognition receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cytoplasmic pattern recognition receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cytoplasmic pattern recognition receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in innate immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in innate immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in innate immune response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical NF-kappaB signal transduction	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within response to bacterium	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in centrosome	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cilium	IBA Inferred from Biological aspect of Ancestor more info
located_in cilium	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in photoreceptor connecting cilium	IDA Inferred from Direct Assay more info	PubMed
located_in spindle pole	ISO Inferred from Sequence Orthology more info
located_in spindle pole	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: alpha-protein kinase 1

Names: lymphocyte alpha-kinase; lymphocyte alpha-protein kinase

NP_082084.1

EC 2.7.11.1

XP_006502164.1

EC 2.7.11.1

XP_006502165.1

EC 2.7.11.1

XP_006502166.1

EC 2.7.11.1

XP_006502167.1

EC 2.7.11.1

XP_006502171.1

EC 2.7.11.1

XP_036019220.1

EC 2.7.11.1

XP_036019221.1

EC 2.7.11.1

XP_036019222.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_027808.1 → NP_082084.1 alpha-protein kinase 1

Status: VALIDATED

Source sequence(s)

AC158308, AC163391

Consensus CDS

CCDS51067.1

UniProtKB/Swiss-Prot

Q69ZH5, Q8BLT9, Q9CXB8

UniProtKB/TrEMBL

E9QNX4

Related

ENSMUSP00000029662.6, ENSMUST00000029662.12

Conserved Domains (1) summary

smart00811
Location:1007 → 1215

Alpha_kinase; Alpha-kinase family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000069.7 Reference GRCm39 C57BL/6J

Range

127460367..127574195 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006502102.4 → XP_006502165.1 alpha-protein kinase 1 isoform X2

UniProtKB/Swiss-Prot

Q69ZH5, Q8BLT9, Q9CXB8

Conserved Domains (1) summary

cd16969
Location:934 → 1160

Alpha_kinase_ALPK1; Alpha-kinase domain of alpha-protein kinase 1
XM_006502101.5 → XP_006502164.1 alpha-protein kinase 1 isoform X1

UniProtKB/Swiss-Prot

Q69ZH5, Q8BLT9, Q9CXB8

Conserved Domains (1) summary

cd16969
Location:990 → 1216

Alpha_kinase_ALPK1; Alpha-kinase domain of alpha-protein kinase 1
XM_036163328.1 → XP_036019221.1 alpha-protein kinase 1 isoform X6

Conserved Domains (1) summary

cd16969
Location:742 → 968

Alpha_kinase_ALPK1; Alpha-kinase domain of alpha-protein kinase 1
XM_006502103.3 → XP_006502166.1 alpha-protein kinase 1 isoform X3

UniProtKB/Swiss-Prot

Q69ZH5, Q8BLT9, Q9CXB8

Conserved Domains (1) summary

cd16969
Location:934 → 1160

Alpha_kinase_ALPK1; Alpha-kinase domain of alpha-protein kinase 1
XM_036163327.1 → XP_036019220.1 alpha-protein kinase 1 isoform X5

Conserved Domains (1) summary

cd16969
Location:742 → 968

Alpha_kinase_ALPK1; Alpha-kinase domain of alpha-protein kinase 1
XM_006502108.3 → XP_006502171.1 alpha-protein kinase 1 isoform X5

See identical proteins and their annotated locations for XP_006502171.1

Conserved Domains (1) summary

cd16969
Location:742 → 968

Alpha_kinase_ALPK1; Alpha-kinase domain of alpha-protein kinase 1
XM_036163329.1 → XP_036019222.1 alpha-protein kinase 1 isoform X7

Conserved Domains (1) summary

cd16969
Location:671 → 897

Alpha_kinase_ALPK1; Alpha-kinase domain of alpha-protein kinase 1
XM_006502104.4 → XP_006502167.1 alpha-protein kinase 1 isoform X4

UniProtKB/Swiss-Prot

Q69ZH5, Q8BLT9, Q9CXB8

Conserved Domains (1) summary

cl28917
Location:990 → 1103

Alpha_kinase; Alpha kinase family