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    Arhgap9 Rho GTPase activating protein 9 [ Mus musculus (house mouse) ]

    Gene ID: 216445, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Arhgap9provided by MGI
    Official Full Name
    Rho GTPase activating protein 9provided by MGI
    Primary source
    MGI:MGI:2143764
    See related
    Ensembl:ENSMUSG00000040345 AllianceGenome:MGI:2143764
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable GTPase activator activity and phosphatidylinositol-3,4,5-trisphosphate binding activity. Predicted to be involved in small GTPase-mediated signal transduction. Predicted to be active in cytoplasm and plasma membrane. Is expressed in thymus primordium. Orthologous to human ARHGAP9 (Rho GTPase activating protein 9). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in spleen adult (RPKM 29.2), thymus adult (RPKM 26.5) and 14 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Arhgap9 in Genome Data Viewer
    Location:
    10 D3; 10 74.5 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (127157829..127165816)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (127321913..127329947)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene DNA-damage inducible transcript 3 Neighboring gene methionine-tRNA synthetase 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:126748829-126749012 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E10653 Neighboring gene GLI-Kruppel family member GLI1 Neighboring gene STARR-positive B cell enhancer ABC_E10654 Neighboring gene STARR-positive B cell enhancer ABC_E9811 Neighboring gene inhibin beta-E Neighboring gene inhibin beta-C

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. WDFY4 is required for cross-presentation in response to viral and tumor antigens. Theisen DJ, et al. Science, 2018 Nov 9. PMID 30409884, Free PMC Article
    2. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
    3. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    4. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
    5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC37568

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol-3,4,5-trisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in small GTPase-mediated signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    rho GTPase-activating protein 9

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001285785.2 → NP_001272714.1  rho GTPase-activating protein 9 isoform 1

      See identical proteins and their annotated locations for NP_001272714.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC114678
      Consensus CDS
      CCDS88101.1
      UniProtKB/TrEMBL
      Q1HDU4
      Related
      ENSMUSP00000151690.2, ENSMUST00000219511.2
      Conserved Domains (5) summary
      cd04403
      Location:438 → 642
      RhoGAP_ARHGAP27_15_12_9; RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. ...
      cd13233
      Location:236 → 349
      PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
      pfam00169
      Location:250 → 348
      PH; PH domain
      cl01020
      Location:346 → 432
      ASCH; ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation, ...
      cl17036
      Location:26 → 82
      SH3; Src Homology 3 domain superfamily

    2. NM_001359656.1 → NP_001346585.1  rho GTPase-activating protein 9 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC114678, AK047280, AK049245
      Consensus CDS
      CCDS36079.1
      UniProtKB/TrEMBL
      Q3TIR9, Q8C293, Q8QZW8
      Related
      ENSMUSP00000151574.2, ENSMUST00000219026.2
      Conserved Domains (2) summary
      cd04403
      Location:263 → 467
      RhoGAP_ARHGAP27_15_12_9; RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. ...
      cd13233
      Location:61 → 174
      PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain

    3. NM_001359657.1 → NP_001346586.1  rho GTPase-activating protein 9 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC114678, AK049245, AK083474
      UniProtKB/TrEMBL
      Q3TIR9, Q78T58
      Conserved Domains (2) summary
      cd04403
      Location:196 → 400
      RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...
      cd13233
      Location:1 → 107
      PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain

    4. NM_146011.3 → NP_666123.2  rho GTPase-activating protein 9 isoform 2

      See identical proteins and their annotated locations for NP_666123.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate exon in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC114678, AK049245, BY315862
      Consensus CDS
      CCDS36079.1
      UniProtKB/TrEMBL
      Q3TIR9, Q8C293, Q8QZW8
      Related
      ENSMUSP00000066455.6, ENSMUST00000069548.7
      Conserved Domains (2) summary
      cd04403
      Location:263 → 467
      RhoGAP_ARHGAP27_15_12_9; RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. ...
      cd13233
      Location:61 → 174
      PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      127157829..127165816
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006513569.5 → XP_006513632.1  rho GTPase-activating protein 9 isoform X1

      Conserved Domains (3) summary
      cd13233
      Location:236 → 349
      PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
      cl02570
      Location:438 → 592
      RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
      cl17036
      Location:26 → 82
      SH3; Src Homology 3 domain superfamily

    2. XM_006513571.5 → XP_006513634.1  rho GTPase-activating protein 9 isoform X2

      See identical proteins and their annotated locations for XP_006513634.1

      UniProtKB/TrEMBL
      Q3TIR9, Q78T58
      Conserved Domains (2) summary
      cd04403
      Location:196 → 400
      RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...
      cd13233
      Location:1 → 107
      PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
    Nucleotide Protein Strain
    Heading Accession and Version

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