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    Rad17 RAD17 checkpoint clamp loader component [ Mus musculus (house mouse) ]

    Gene ID: 19356, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rad17provided by MGI
    Official Full Name
    RAD17 checkpoint clamp loader componentprovided by MGI
    Primary source
    MGI:MGI:1333807
    See related
    Ensembl:ENSMUSG00000021635 AllianceGenome:MGI:1333807
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MmRad24
    Summary
    Predicted to enable chromatin binding activity and chromatin-protein adaptor activity. Predicted to contribute to DNA clamp loader activity. Acts upstream of or within DNA damage response. Predicted to be located in nucleoplasm. Predicted to be part of Rad17 RFC-like complex. Predicted to be active in site of double-strand break. Predicted to colocalize with chromosome, telomeric region. Is expressed in cerebral cortex; embryo; and telencephalon. Orthologous to human RAD17 (RAD17 checkpoint clamp loader component). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in placenta adult (RPKM 6.8), CNS E11.5 (RPKM 6.5) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rad17 in Genome Data Viewer
    Location:
    13 D1; 13 53.23 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (100753672..100787569, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (100617164..100651061, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 4, gamma 1 pseudogene Neighboring gene MARVEL (membrane-associating) domain containing 2 Neighboring gene predicted gene, 24261 Neighboring gene STARR-positive B cell enhancer ABC_E7268 Neighboring gene TATA-box binding protein associated factor 9 Neighboring gene adenylate kinase 6 Neighboring gene STARR-seq mESC enhancer starr_35476 Neighboring gene coiled-coil domain containing 125 Neighboring gene cyclin dependent kinase 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The mammalian Rad24 homologous to yeast Saccharomyces cerevisiae Rad24 and Schizosaccharomyces pombe Rad17 is involved in DNA damage checkpoint. Bao S, et al. Cell Growth Differ, 1998 Dec. PMID 9869296
    2. Human and mouse homologs of the Schizosaccharomyces pombe rad17+ cell cycle checkpoint control gene. Bluyssen HA, et al. Genomics, 1999 Jan 15. PMID 9933569
    3. HRad17, a human homologue of the Schizosaccharomyces pombe checkpoint gene rad17, is overexpressed in colon carcinoma. Bao S, et al. Cancer Res, 1999 May 1. PMID 10232579
    4. Phosphorylation of serines 635 and 645 of human Rad17 is cell cycle regulated and is required for G(1)/S checkpoint activation in response to DNA damage. Post S, et al. Proc Natl Acad Sci U S A, 2001 Nov 6. PMID 11687627, Free PMC Article
    5. Mutation of the mouse Rad17 gene leads to embryonic lethality and reveals a role in DNA damage-dependent recombination. Budzowska M, et al. EMBO J, 2004 Sep 1. PMID 15297881, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • 9430035O09Rik

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to DNA clamp loader activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA clamp loader activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chromatin-protein adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables chromatin-protein adaptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within DNA damage response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in DNA repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic DNA replication checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic intra-S DNA damage checkpoint signaling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic intra-S DNA damage checkpoint signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of DNA replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to site of double-strand break ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to site of double-strand break ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of Rad17 RFC-like complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome, telomeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    colocalizes_with chromosome, telomeric region ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in site of double-strand break ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in site of double-strand break ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    cell cycle checkpoint protein RAD17
    Names
    RAD17 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001044371.2 → NP_001037836.1  cell cycle checkpoint protein RAD17 isoform 1

      See identical proteins and their annotated locations for NP_001037836.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AC165159, AK134277, BC066855, BY129390
      Consensus CDS
      CCDS26733.1
      UniProtKB/Swiss-Prot
      O88934, O89024, Q6NXW6
      UniProtKB/TrEMBL
      Q3UYY2
      Related
      ENSMUSP00000136292.2, ENSMUST00000177848.3
      Conserved Domains (1) summary
      TIGR00602
      Location:13 → 653
      rad24; checkpoint protein rad24

    2. NM_001283011.1 → NP_001269940.1  cell cycle checkpoint protein RAD17 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains an alternate exon in its 5' UTR and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC165159, AK134277, AK167358, BC066855, BY129390
      UniProtKB/Swiss-Prot
      Q6NXW6
      UniProtKB/TrEMBL
      Q3UYY2
      Conserved Domains (1) summary
      TIGR00602
      Location:1 → 444
      rad24; checkpoint protein rad24

    3. NM_011233.3 → NP_035363.2  cell cycle checkpoint protein RAD17 isoform 1

      See identical proteins and their annotated locations for NP_035363.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1). Both variants 1 and 2 encode the same isoform.
      Source sequence(s)
      AC165159, AK134277, BC066855, BY129390, CF916039
      Consensus CDS
      CCDS26733.1
      UniProtKB/Swiss-Prot
      O88934, O89024, Q6NXW6
      UniProtKB/TrEMBL
      Q3UYY2
      Related
      ENSMUSP00000022136.7, ENSMUST00000022136.14
      Conserved Domains (1) summary
      TIGR00602
      Location:13 → 653
      rad24; checkpoint protein rad24

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      100753672..100787569 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036157920.1 → XP_036013813.1  cell cycle checkpoint protein RAD17 isoform X1

      UniProtKB/Swiss-Prot
      O88934, O89024, Q6NXW6
      UniProtKB/TrEMBL
      Q3UYY2
      Conserved Domains (1) summary
      TIGR00602
      Location:13 → 653
      rad24; checkpoint protein rad24
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6NXW6.2 GenPept UniProtKB/Swiss-Prot:Q6NXW6

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