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    Scin scinderin [ Mus musculus (house mouse) ]

    Gene ID: 20259, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Scinprovided by MGI
    Official Full Name
    scinderinprovided by MGI
    Primary source
    MGI:MGI:1306794
    See related
    Ensembl:ENSMUSG00000002565 AllianceGenome:MGI:1306794
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    adseverin
    Summary
    Predicted to enable actin filament binding activity and phosphatidylinositol-4,5-bisphosphate binding activity. Predicted to be involved in several processes, including actin polymerization or depolymerization; positive regulation of megakaryocyte differentiation; and regulation of actin filament organization. Located in brush border. Is expressed in several structures, including adrenal gland; female reproductive system; gut; hemolymphoid system gland; and metanephros. Orthologous to human SCIN (scinderin). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in colon adult (RPKM 56.3), large intestine adult (RPKM 22.6) and 4 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Scin in Genome Data Viewer
    Location:
    12 B1; 12 18.06 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (40109768..40184227, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (40059769..40134228, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr12:40763838-40764139 Neighboring gene STARR-positive B cell enhancer ABC_E7130 Neighboring gene ADP-ribosylation factor-like 4A, opposite strand Neighboring gene ADP-ribosylation factor-like 4A Neighboring gene leucine-rich single-pass membrane protein 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:40926695-40926804 Neighboring gene interferon-related developmental regulator 1 Neighboring gene microRNA 1938

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Murine adseverin (D5), a novel member of the gelsolin family, and murine adseverin are induced by interleukin-9 in T-helper lymphocytes. Robbens J, et al. Mol Cell Biol, 1998 Aug. PMID 9671468, Free PMC Article
    2. Adseverin, an actin-binding protein, modulates hypertrophic chondrocyte differentiation and osteoarthritis progression. Chan B, et al. Sci Adv, 2023 Aug 4. PMID 37540756, Free PMC Article
    3. The actin binding protein adseverin regulates osteoclastogenesis. Hassanpour S, et al. PLoS One, 2014. PMID 25275604, Free PMC Article
    4. Adseverin plays a role in osteoclast differentiation and periodontal disease-mediated bone loss. Jiang H, et al. FASEB J, 2015 Jun. PMID 25681458
    5. Deletion of Adseverin in Osteoclasts Affects Cell Structure But Not Bone Metabolism. Cao Y, et al. Calcif Tissue Int, 2017 Aug. PMID 28389691, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Scinderin Promotes Hydrogen Peroxide-induced Lens Epithelial Cell Injury in Age-related Cataract.
      Title: Scinderin Promotes Hydrogen Peroxide-induced Lens Epithelial Cell Injury in Age-related Cataract.
    2. Autophagy regulation and protein kinase activity of PIK3C3 controls sertoli cell polarity through its negative regulation on SCIN (scinderin).
      Title: Autophagy regulation and protein kinase activity of PIK3C3 controls sertoli cell polarity through its negative regulation on SCIN (scinderin).
    3. Adseverin, an actin-binding protein, modulates hypertrophic chondrocyte differentiation and osteoarthritis progression.
      Title: Adseverin, an actin-binding protein, modulates hypertrophic chondrocyte differentiation and osteoarthritis progression.
    4. Scinderin promotes fusion of electron transport chain dysfunctional muscle stem cells with myofibers.
      Title: Scinderin promotes fusion of electron transport chain dysfunctional muscle stem cells with myofibers.
    5. IL1beta and TNFalpha enhance RANKL-dependent expression of adseverin, which contributes to fusion processes in osteoclastogenesis
      Title: IL1β and TNFα promote RANKL-dependent adseverin expression and osteoclastogenesis.
    6. indicate that in healthy, developing tissues, adseverin contributes to the regulation of osteoclast structure but not to bone metabolism in vivo
      Title: Deletion of Adseverin in Osteoclasts Affects Cell Structure But Not Bone Metabolism.
    7. Adseverin knockdown also suppressed the RANKL-mediated induction of nuclear factor of activated T-cell c1 (NFATc1), which is a key transcription factor in osteoclastogenesis.
      Title: Adseverin mediates RANKL-induced osteoclastogenesis by regulating NFATc1.
    8. Data indicate that adseverin (Ads) regulates actin cytoskeleton in osteoclasts.
      Title: Adseverin plays a role in osteoclast differentiation and periodontal disease-mediated bone loss.
    9. Ads is a RANKL induced early regulator of osteoclastogenesis with a potential role in pre-osteoclast differentiation and fusion.
      Title: The actin binding protein adseverin regulates osteoclastogenesis.
    10. Overexpression of Scin is associated with asthma.
      Title: New asthma biomarkers: lessons from murine models of acute and chronic asthma.
    Submit: New GeneRIF Correction See all GeneRIFs (11)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1) 
    • Endonuclease-mediated (3) 
    • Targeted (1)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables actin filament binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol-4,5-bisphosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin filament capping IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in actin filament capping ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in actin filament severing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin filament severing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in actin filament severing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in actin polymerization or depolymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in barbed-end actin filament capping IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell projection assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in central nervous system development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of actin nucleation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of actin nucleation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of megakaryocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of megakaryocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of chondrocyte differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in sequestering of actin monomers IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sequestering of actin monomers ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in anchoring junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in brush border IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in podosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of protein-containing complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    scinderin
    Names
    gelsolin-like protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001146196.1 → NP_001139668.1  scinderin isoform 1

      See identical proteins and their annotated locations for NP_001139668.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      BC063328, BY201136, Y13971
      Consensus CDS
      CCDS49055.1
      UniProtKB/Swiss-Prot
      O08988, O08990, Q60604, Q6P4N8
      UniProtKB/TrEMBL
      Q69Z71
      Related
      ENSMUSP00000002640.6, ENSMUST00000002640.6
      Conserved Domains (6) summary
      cd11288
      Location:508 → 598
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:136 → 225
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:10 → 121
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:613 → 711
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:246 → 346
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:390 → 486
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

    2. NM_009132.2 → NP_033158.2  scinderin isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks two exons in the 3' coding region compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1.
      Source sequence(s)
      AK136080, BY201136, Y13971
      Consensus CDS
      CCDS25891.1
      UniProtKB/TrEMBL
      Q69Z71
      Related
      ENSMUSP00000077573.8, ENSMUST00000078481.14
      Conserved Domains (5) summary
      cd11289
      Location:136 → 225
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:10 → 121
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:509 → 611
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:246 → 346
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:390 → 486
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      40109768..40184227 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q60604.3 GenPept UniProtKB/Swiss-Prot:Q60604

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
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