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    Tmem52 transmembrane protein 52 [ Mus musculus (house mouse) ]

    Gene ID: 69671, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tmem52provided by MGI
    Official Full Name
    transmembrane protein 52provided by MGI
    Primary source
    MGI:MGI:1916921
    See related
    Ensembl:ENSMUSG00000023153 AllianceGenome:MGI:1916921
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2310043I08Rik
    Summary
    Predicted to be located in membrane. Orthologous to human TMEM52 (transmembrane protein 52). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in adrenal adult (RPKM 47.2), mammary gland adult (RPKM 11.6) and 4 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tmem52 in Genome Data Viewer
    Location:
    4 E2; 4 86.17 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (155553571..155555315)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (155469114..155470858)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 5830444B04 gene Neighboring gene gamma-aminobutyric acid (GABA) A receptor, subunit delta Neighboring gene cilia and flagella associated protein 74 Neighboring gene STARR-positive B cell enhancer ABC_E4738 Neighboring gene STARR-seq mESC enhancer starr_12263 Neighboring gene guanine nucleotide binding protein (G protein), beta 1 Neighboring gene NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 pseudogene Neighboring gene STARR-seq mESC enhancer starr_12266 Neighboring gene STARR-positive B cell enhancer ABC_E340 Neighboring gene STARR-positive B cell enhancer ABC_E10296 Neighboring gene NAD kinase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A mouse knockout library for secreted and transmembrane proteins. Tang T, et al. Nat Biotechnol, 2010 Jul. PMID 20562862
    2. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    3. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane protein 52

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001253856.1 → NP_001240785.1  transmembrane protein 52 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001240785.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AL670227
      Consensus CDS
      CCDS57319.1
      UniProtKB/Swiss-Prot
      Q9D702
      UniProtKB/TrEMBL
      B2RWS8
      Related
      ENSMUSP00000023920.3, ENSMUST00000023920.3
      Conserved Domains (1) summary
      pfam14979
      Location:37 → 176
      TMEM52; Transmembrane 52

    2. NM_001253858.1 → NP_001240787.1  transmembrane protein 52 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an in-frame exon in the coding region, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
      Source sequence(s)
      AL670227
      Consensus CDS
      CCDS57320.1
      UniProtKB/TrEMBL
      B2RWS8, J3QNP8
      Related
      ENSMUSP00000136899.2, ENSMUST00000178188.8
      Conserved Domains (1) summary
      pfam14979
      Location:49 → 162
      TMEM52; Transmembrane 52

    3. NM_027161.2 → NP_081437.1  transmembrane protein 52 isoform 1 precursor

      See identical proteins and their annotated locations for NP_081437.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AL670227, BC144992
      Consensus CDS
      CCDS57318.1
      UniProtKB/TrEMBL
      B2RWS8, B7ZN39
      Related
      ENSMUSP00000136919.2, ENSMUST00000178238.8
      Conserved Domains (1) summary
      pfam14979
      Location:44 → 182
      TMEM52; Transmembrane 52

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      155553571..155555315
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D702.1 GenPept UniProtKB/Swiss-Prot:Q9D702

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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