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    TLK2 tousled like kinase 2 [ Homo sapiens (human) ]

    Gene ID: 11011, updated on 9-Dec-2024

    Summary

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    Official Symbol
    TLK2provided by HGNC
    Official Full Name
    tousled like kinase 2provided by HGNC
    Primary source
    HGNC:HGNC:11842
    See related
    Ensembl:ENSG00000146872 MIM:608439; AllianceGenome:HGNC:11842
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HsHPK; MRD57; PKU-ALPHA
    Summary
    This gene encodes a nuclear serine/threonine kinase that was first identified in Arabidopsis. The encoded protein is thought to function in the regulation of chromatin assembly in the S phase of the cell cycle by regulating the levels of a histone H3/H4 chaperone. This protein is associated with double-strand break repair of DNA damage caused by radiation. Pseudogenes of this gene are present on chromosomes 10 and 17. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
    Expression
    Broad expression in testis (RPKM 14.1), bone marrow (RPKM 5.4) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See TLK2 in Genome Data Viewer
    Location:
    17q23.2
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (62470914..62615481)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (63340853..63485425)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (60555172..60692842)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:60500991-60501521 Neighboring gene methyltransferase 2A, tRNA N3-cytidine Neighboring gene uncharacterized LOC112268200 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:60541227-60541728 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:60541729-60542228 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8805 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8806 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8807 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8808 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr17:60562255-60562754 Neighboring gene MPRA-validated peak2934 silencer Neighboring gene ribosomal protein S10 pseudogene 26 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:60622822-60623322 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:60636816-60637174 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr17:60642433-60643632 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:60645420-60645891 Neighboring gene MPRA-validated peak2935 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12540 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:60696223-60696734 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:60702756-60703256 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:60703257-60703757 Neighboring gene uncharacterized LOC107985020 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8809 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8810 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:60707912-60708768 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:60729214-60729925 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:60729926-60730636 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:60731349-60732059 Neighboring gene mannose receptor C-type 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:60743431-60744021 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:60746820-60747579 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:60747580-60748338 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:60748658-60749158 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:60749159-60749659 Neighboring gene Sharpr-MPRA regulatory region 5505 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:60757143-60757871 Neighboring gene RNA, U6 small nuclear 446, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Tousled-like kinases modulate reactivation of gammaherpesviruses from latency. Dillon PJ, et al. Cell Host Microbe, 2013 Feb 13. PMID 23414760, Free PMC Article
    2. Tousled-like kinase 2 regulates recovery from a DNA damage-induced G2 arrest. Bruinsma W, et al. EMBO Rep, 2016 May. PMID 26931568, Free PMC Article
    3. Amplification of TLK2 Induces Genomic Instability via Impairing the G2-M Checkpoint. Kim JA, et al. Mol Cancer Res, 2016 Oct. PMID 27489360, Free PMC Article
    4. Comprehensive functional analysis of the tousled-like kinase 2 frequently amplified in aggressive luminal breast cancers. Kim JA, et al. Nat Commun, 2016 Oct 3. PMID 27694828, Free PMC Article
    5. De Novo and Inherited Loss-of-Function Variants in TLK2: Clinical and Genotype-Phenotype Evaluation of a Distinct Neurodevelopmental Disorder. Reijnders MRF, et al. Am J Hum Genet, 2018 Jun 7. PMID 29861108, Free PMC Article

    See all (72) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. [Effect of TLK2 Expression Regulated by MiR-21 on Proliferation and Apoptosis of Acute Myeloid Leukemia Cells].
      Title: [Effect of TLK2 Expression Regulated by MiR-21 on Proliferation and Apoptosis of Acute Myeloid Leukemia Cells].
    2. Tousled-like kinase 2 targets ASF1 histone chaperones through client mimicry.
      Title: Tousled-like kinase 2 targets ASF1 histone chaperones through client mimicry.
    3. Functional analysis of TLK2 variants and their proximal interactomes implicates impaired kinase activity and chromatin maintenance defects in their pathogenesis.
      Title: Functional analysis of TLK2 variants and their proximal interactomes implicates impaired kinase activity and chromatin maintenance defects in their pathogenesis.
    4. Tousled-Like Kinases Suppress Innate Immune Signaling Triggered by Alternative Lengthening of Telomeres.
      Title: Tousled-Like Kinases Suppress Innate Immune Signaling Triggered by Alternative Lengthening of Telomeres.
    5. Study shows that TLK2 expression is increased in glioblastoma. Furthermore, TLK2 overexpression resulted in tumor growth and metastasis via SRC signaling pathway.
      Title: TLK2 enhances aggressive phenotypes of glioblastoma cells through the activation of SRC signaling pathway.
    6. haploinsufficiency of TLK2 is the most likely underlying disease mechanism, leading to a consistent neurodevelopmental phenotype.
      Title: De Novo and Inherited Loss-of-Function Variants in TLK2: Clinical and Genotype-Phenotype Evaluation of a Distinct Neurodevelopmental Disorder.
    7. Molecular basis of TLK2 activation and inhibition has been dissected.
      Title: Molecular basis of Tousled-Like Kinase 2 activation.
    8. TLK2 is amplified in aggressive luminal breast neoplasms
      Title: Comprehensive functional analysis of the tousled-like kinase 2 frequently amplified in aggressive luminal breast cancers.
    9. Tlk2 promotes Asf1A function during the DNA damage response in G2 to allow for proper restoration of chromatin structure at the break site and subsequent recovery from the arrest.
      Title: Tousled-like kinase 2 regulates recovery from a DNA damage-induced G2 arrest.
    10. Results show that TLK2 overexpression correlates with increased genome-wide copy number aberrations in breast cancer cells, impairs cell-cycle checkpoint signaling in response to DNA damage.
      Title: Amplification of TLK2 Induces Genomic Instability via Impairing the G2-M Checkpoint.
    Submit: New GeneRIF Correction See all GeneRIFs (15)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Intellectual disability, autosomal dominant 57
    MedGen: C4748003 OMIM: 618050 GeneReviews: Not available
    		Compare labs

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of tousled-like kinase 2 (TLK2) by siRNA has both activating and inhibiting activities on HIV-1 replication in HeLa P4/R5 cells, suggesting a regulatory role in HIV replication PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC44450

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cellular response to gamma radiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromosome segregation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of autophagy NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nucleus localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in peptidyl-serine phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of chromatin organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in intermediate filament IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in perinuclear region of cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    serine/threonine-protein kinase tousled-like 2
    NP_001271262.1
    NP_001271292.1
    NP_001317347.1
    NP_001362198.1
    NP_001362199.1
    NP_001362200.1
    NP_001362201.1
    NP_001362202.1
    NP_001398003.1
    NP_006843.2
    XP_011522517.2
    XP_011522518.1
    XP_011522520.2
    XP_011522522.2
    XP_011522523.1
    XP_011522524.1
    XP_011522525.1
    XP_011522528.1
    XP_011522529.1
    XP_011522533.2
    XP_016879533.2
    XP_016879537.1
    XP_016879538.1
    XP_016879539.1
    XP_016879540.1
    XP_016879542.1
    XP_016879543.1
    XP_016879544.1
    XP_024306320.1
    XP_024306321.1
    XP_047291130.1
    XP_047291131.1
    XP_047291132.1
    XP_047291133.1
    XP_047291134.1
    XP_047291135.1
    XP_047291136.1
    XP_047291137.1
    XP_047291138.1
    XP_047291139.1
    XP_047291141.1
    XP_047291142.1
    XP_047291143.1
    XP_054170754.1
    XP_054170755.1
    XP_054170756.1
    XP_054170757.1
    XP_054170758.1
    XP_054170759.1
    XP_054170760.1
    XP_054170761.1
    XP_054170762.1
    XP_054170763.1
    XP_054170764.1
    XP_054170765.1
    XP_054170766.1
    XP_054170767.1
    XP_054170768.1
    XP_054170769.1
    XP_054170770.1
    XP_054170771.1
    XP_054170772.1
    XP_054170773.1
    XP_054170774.1
    XP_054170775.1
    XP_054170776.1
    XP_054170777.1
    XP_054170778.1
    XP_054170779.1
    XP_054170780.1
    XP_054170781.1
    XP_054170782.1
    XP_054170783.1
    XP_054170784.1
    XP_054170785.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001284333.3 → NP_001271262.1  serine/threonine-protein kinase tousled-like 2 isoform C

      See identical proteins and their annotated locations for NP_001271262.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (C) represents the longest transcript and encodes the longest isoform (C).
      Source sequence(s)
      AC080038, AI381985, BC044925, BX647225
      Consensus CDS
      CCDS62283.1
      UniProtKB/Swiss-Prot
      D3DU07, Q86UE8, Q9UKI7, Q9Y4F7
      UniProtKB/TrEMBL
      B4DUC2
      Related
      ENSP00000316512.9, ENST00000326270.13
      Conserved Domains (2) summary
      cd14041
      Location:455 → 763
      STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2
      cl25732
      Location:202 → 437
      SMC_N; RecF/RecN/SMC N terminal domain

    2. NM_001284363.1 → NP_001271292.1  serine/threonine-protein kinase tousled-like 2 isoform B

      See identical proteins and their annotated locations for NP_001271292.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (B) differs in the 5' UTR and lacks two alternate in-frame exons in the coding region compared to variant C. The encoded protein (isoform B) is shorter than isoform C.
      Source sequence(s)
      AC008026, AC080038, AK300586, BM668399, BX647225
      Consensus CDS
      CCDS45753.1
      UniProtKB/TrEMBL
      B4DUC2
      Related
      ENSP00000508242.1, ENST00000683104.1
      Conserved Domains (2) summary
      COG1196
      Location:174 → 471
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd14041
      Location:401 → 709
      STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2

    3. NM_001330418.3 → NP_001317347.1  serine/threonine-protein kinase tousled-like 2 isoform D

      Status: REVIEWED

      Source sequence(s)
      AC008026, AC080038, BM668399
      Consensus CDS
      CCDS82182.1
      UniProtKB/TrEMBL
      B4DUC2, J3QLK5
      Related
      ENSP00000508315.1, ENST00000683536.1
      Conserved Domains (2) summary
      COG1196
      Location:57 → 354
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd14041
      Location:284 → 592
      STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2

    4. NM_001375269.1 → NP_001362198.1  serine/threonine-protein kinase tousled-like 2 isoform E

      Status: REVIEWED

      Source sequence(s)
      AC008026, AC080038
      UniProtKB/TrEMBL
      B4DUC2
      Conserved Domains (2) summary
      COG1196
      Location:220 → 517
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd14041
      Location:447 → 755
      STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2

    5. NM_001375270.1 → NP_001362199.1  serine/threonine-protein kinase tousled-like 2 isoform A

      Status: REVIEWED

      Source sequence(s)
      AC008026, AC080038
      Consensus CDS
      CCDS11633.1
      UniProtKB/TrEMBL
      B4DUC2
      Conserved Domains (2) summary
      COG1196
      Location:206 → 503
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd14041
      Location:433 → 741
      STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2

    6. NM_001375271.1 → NP_001362200.1  serine/threonine-protein kinase tousled-like 2 isoform A

      Status: REVIEWED

      Source sequence(s)
      AC008026, AC080038
      Consensus CDS
      CCDS11633.1
      UniProtKB/TrEMBL
      B4DUC2
      Related
      ENSP00000506744.1, ENST00000682085.1
      Conserved Domains (2) summary
      COG1196
      Location:206 → 503
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd14041
      Location:433 → 741
      STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2

    7. NM_001375272.1 → NP_001362201.1  serine/threonine-protein kinase tousled-like 2 isoform B

      Status: REVIEWED

      Source sequence(s)
      AC008026, AC080038
      Consensus CDS
      CCDS45753.1
      UniProtKB/TrEMBL
      B4DUC2
      Related
      ENSP00000506988.1, ENST00000682075.1
      Conserved Domains (2) summary
      COG1196
      Location:174 → 471
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd14041
      Location:401 → 709
      STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2

    8. NM_001375273.1 → NP_001362202.1  serine/threonine-protein kinase tousled-like 2 isoform D

      Status: REVIEWED

      Source sequence(s)
      AC008026, AC080038
      Consensus CDS
      CCDS82182.1
      UniProtKB/TrEMBL
      B4DUC2, J3QLK5
      Related
      ENSP00000507584.1, ENST00000682203.1
      Conserved Domains (2) summary
      COG1196
      Location:57 → 354
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd14041
      Location:284 → 592
      STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2

    9. NM_001411074.1 → NP_001398003.1  serine/threonine-protein kinase tousled-like 2 isoform F

      Status: REVIEWED

      Source sequence(s)
      AC008026, AC080038
      Consensus CDS
      CCDS92374.1
      UniProtKB/TrEMBL
      A0A804HK10, A0A804HKF1

    10. NM_006852.6 → NP_006843.2  serine/threonine-protein kinase tousled-like 2 isoform A

      See identical proteins and their annotated locations for NP_006843.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (A) lacks an alternate in-frame exon in the 3' coding region compared to variant C. The encoded protein (isoform A) is shorter than isoform C.
      Source sequence(s)
      AB004884, AC008026, AC080038, AF162667, AI381985, BX647225
      Consensus CDS
      CCDS11633.1
      UniProtKB/TrEMBL
      B4DUC2
      Related
      ENSP00000275780.7, ENST00000346027.10
      Conserved Domains (2) summary
      COG1196
      Location:206 → 503
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd14041
      Location:433 → 741
      STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      62470914..62615481
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024450552.2 → XP_024306320.1  serine/threonine-protein kinase tousled-like 2 isoform X7

      UniProtKB/TrEMBL
      B4DUC2
      Conserved Domains (2) summary
      cd14041
      Location:462 → 770
      STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2
      cl25732
      Location:209 → 444
      SMC_N; RecF/RecN/SMC N terminal domain

    2. XM_024450553.2 → XP_024306321.1  serine/threonine-protein kinase tousled-like 2 isoform X8

      UniProtKB/Swiss-Prot
      D3DU07, Q86UE8, Q9UKI7, Q9Y4F7
      UniProtKB/TrEMBL
      B4DUC2
      Conserved Domains (2) summary
      cd14041
      Location:455 → 763
      STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2
      cl25732
      Location:202 → 437
      SMC_N; RecF/RecN/SMC N terminal domain

    3. XM_047435179.1 → XP_047291135.1  serine/threonine-protein kinase tousled-like 2 isoform X12

      UniProtKB/TrEMBL
      B4DUC2

    4. XM_011524221.3 → XP_011522523.1  serine/threonine-protein kinase tousled-like 2 isoform X13

      UniProtKB/TrEMBL
      B4DUC2
      Conserved Domains (2) summary
      cd14041
      Location:423 → 731
      STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2
      cl25732
      Location:170 → 405
      SMC_N; RecF/RecN/SMC N terminal domain

    5. XM_047435182.1 → XP_047291138.1  serine/threonine-protein kinase tousled-like 2 isoform X16

      UniProtKB/TrEMBL
      B4DUC2

    6. XM_011524216.3 → XP_011522518.1  serine/threonine-protein kinase tousled-like 2 isoform X8

      See identical proteins and their annotated locations for XP_011522518.1

      UniProtKB/Swiss-Prot
      D3DU07, Q86UE8, Q9UKI7, Q9Y4F7
      UniProtKB/TrEMBL
      B4DUC2
      Conserved Domains (2) summary
      cd14041
      Location:455 → 763
      STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2
      cl25732
      Location:202 → 437
      SMC_N; RecF/RecN/SMC N terminal domain

    7. XM_047435183.1 → XP_047291139.1  serine/threonine-protein kinase tousled-like 2 isoform X17

      UniProtKB/TrEMBL
      A0A804HKF1

    8. XM_047435185.1 → XP_047291141.1  serine/threonine-protein kinase tousled-like 2 isoform X19

      UniProtKB/TrEMBL
      A0A804HJZ9, A0A804HKF1

    9. XM_047435180.1 → XP_047291136.1  serine/threonine-protein kinase tousled-like 2 isoform X13

      UniProtKB/TrEMBL
      B4DUC2

    10. XM_017024053.3 → XP_016879542.1  serine/threonine-protein kinase tousled-like 2 isoform X16

      UniProtKB/TrEMBL
      B4DUC2
      Conserved Domains (2) summary
      COG1196
      Location:174 → 471
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd14041
      Location:401 → 709
      STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2

    11. XM_011524222.4 → XP_011522524.1  serine/threonine-protein kinase tousled-like 2 isoform X8

      See identical proteins and their annotated locations for XP_011522524.1

      UniProtKB/Swiss-Prot
      D3DU07, Q86UE8, Q9UKI7, Q9Y4F7
      UniProtKB/TrEMBL
      B4DUC2
      Conserved Domains (2) summary
      cd14041
      Location:455 → 763
      STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2
      cl25732
      Location:202 → 437
      SMC_N; RecF/RecN/SMC N terminal domain

    12. XM_017024054.3 → XP_016879543.1  serine/threonine-protein kinase tousled-like 2 isoform X19

      UniProtKB/TrEMBL
      A0A804HJZ9, A0A804HKF1
      Related
      ENSP00000507712.1, ENST00000684440.1

    13. XM_017024048.3 → XP_016879537.1  serine/threonine-protein kinase tousled-like 2 isoform X13

      UniProtKB/TrEMBL
      B4DUC2
      Conserved Domains (2) summary
      cd14041
      Location:423 → 731
      STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2
      cl25732
      Location:170 → 405
      SMC_N; RecF/RecN/SMC N terminal domain

    14. XM_017024051.3 → XP_016879540.1  serine/threonine-protein kinase tousled-like 2 isoform X16

      UniProtKB/TrEMBL
      B4DUC2
      Related
      ENSP00000340800.7, ENST00000343388.11
      Conserved Domains (2) summary
      COG1196
      Location:174 → 471
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd14041
      Location:401 → 709
      STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2

    15. XM_017024055.3 → XP_016879544.1  serine/threonine-protein kinase tousled-like 2 isoform X21

      UniProtKB/TrEMBL
      A0A804HK10, A0A804HKF1
      Related
      ENSP00000507724.1, ENST00000684772.1

    16. XM_017024049.3 → XP_016879538.1  serine/threonine-protein kinase tousled-like 2 isoform X13

      UniProtKB/TrEMBL
      B4DUC2
      Conserved Domains (2) summary
      cd14041
      Location:423 → 731
      STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2
      cl25732
      Location:170 → 405
      SMC_N; RecF/RecN/SMC N terminal domain

    17. XM_011524223.4 → XP_011522525.1  serine/threonine-protein kinase tousled-like 2 isoform X18

      UniProtKB/TrEMBL
      A0A804HKF1
      Conserved Domains (2) summary
      smart00220
      Location:410 → 678
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14041
      Location:392 → 700
      STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2

    18. XM_047435174.1 → XP_047291130.1  serine/threonine-protein kinase tousled-like 2 isoform X1

      UniProtKB/TrEMBL
      B4DUC2

    19. XM_047435176.1 → XP_047291132.1  serine/threonine-protein kinase tousled-like 2 isoform X3

      UniProtKB/TrEMBL
      B4DUC2

    20. XM_011524215.3 → XP_011522517.2  serine/threonine-protein kinase tousled-like 2 isoform X5

      UniProtKB/TrEMBL
      A0A804HKF1

    21. XM_011524218.3 → XP_011522520.2  serine/threonine-protein kinase tousled-like 2 isoform X9

      UniProtKB/TrEMBL
      A0A804HKF1

    22. XM_011524220.3 → XP_011522522.2  serine/threonine-protein kinase tousled-like 2 isoform X11

      UniProtKB/TrEMBL
      A0A804HKF1

    23. XM_047435181.1 → XP_047291137.1  serine/threonine-protein kinase tousled-like 2 isoform X14

      UniProtKB/TrEMBL
      A0A804HKF1

    24. XM_047435177.1 → XP_047291133.1  serine/threonine-protein kinase tousled-like 2 isoform X6

      UniProtKB/TrEMBL
      B4DUC2

    25. XM_047435178.1 → XP_047291134.1  serine/threonine-protein kinase tousled-like 2 isoform X10

      UniProtKB/TrEMBL
      B4DUC2

    26. XM_047435175.1 → XP_047291131.1  serine/threonine-protein kinase tousled-like 2 isoform X2

      UniProtKB/TrEMBL
      B4DUC2

    27. XM_017024044.2 → XP_016879533.2  serine/threonine-protein kinase tousled-like 2 isoform X4

      UniProtKB/TrEMBL
      B4DUC2

    28. XM_017024050.2 → XP_016879539.1  serine/threonine-protein kinase tousled-like 2 isoform X15

      UniProtKB/TrEMBL
      A0A804HKF1
      Related
      ENSP00000507902.1, ENST00000684012.1

    29. XM_011524231.2 → XP_011522533.2  serine/threonine-protein kinase tousled-like 2 isoform X22

    30. XM_011524226.3 → XP_011522528.1  serine/threonine-protein kinase tousled-like 2 isoform X20

      See identical proteins and their annotated locations for XP_011522528.1

      UniProtKB/TrEMBL
      B4DUC2
      Conserved Domains (2) summary
      smart00220
      Location:369 → 637
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14041
      Location:351 → 659
      STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2

    31. XM_011524227.3 → XP_011522529.1  serine/threonine-protein kinase tousled-like 2 isoform X20

      See identical proteins and their annotated locations for XP_011522529.1

      UniProtKB/TrEMBL
      B4DUC2
      Conserved Domains (2) summary
      smart00220
      Location:369 → 637
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14041
      Location:351 → 659
      STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2

    32. XM_047435187.1 → XP_047291143.1  serine/threonine-protein kinase tousled-like 2 isoform X20

      UniProtKB/TrEMBL
      B4DUC2

    33. XM_047435186.1 → XP_047291142.1  serine/threonine-protein kinase tousled-like 2 isoform X20

      UniProtKB/TrEMBL
      B4DUC2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      63340853..63485425
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054314785.1 → XP_054170760.1  serine/threonine-protein kinase tousled-like 2 isoform X7

      UniProtKB/TrEMBL
      B4DUC2

    2. XM_054314788.1 → XP_054170763.1  serine/threonine-protein kinase tousled-like 2 isoform X8

      UniProtKB/Swiss-Prot
      D3DU07, Q86UE8, Q9UKI7, Q9Y4F7
      UniProtKB/TrEMBL
      B4DUC2

    3. XM_054314792.1 → XP_054170767.1  serine/threonine-protein kinase tousled-like 2 isoform X12

      UniProtKB/TrEMBL
      B4DUC2

    4. XM_054314796.1 → XP_054170771.1  serine/threonine-protein kinase tousled-like 2 isoform X13

      UniProtKB/TrEMBL
      B4DUC2

    5. XM_054314800.1 → XP_054170775.1  serine/threonine-protein kinase tousled-like 2 isoform X16

      UniProtKB/TrEMBL
      B4DUC2

    6. XM_054314786.1 → XP_054170761.1  serine/threonine-protein kinase tousled-like 2 isoform X8

      UniProtKB/Swiss-Prot
      D3DU07, Q86UE8, Q9UKI7, Q9Y4F7
      UniProtKB/TrEMBL
      B4DUC2

    7. XM_054314802.1 → XP_054170777.1  serine/threonine-protein kinase tousled-like 2 isoform X17

      UniProtKB/TrEMBL
      A0A804HKF1

    8. XM_054314804.1 → XP_054170779.1  serine/threonine-protein kinase tousled-like 2 isoform X19

      UniProtKB/TrEMBL
      A0A804HJZ9, A0A804HKF1

    9. XM_054314794.1 → XP_054170769.1  serine/threonine-protein kinase tousled-like 2 isoform X13

      UniProtKB/TrEMBL
      B4DUC2

    10. XM_054314799.1 → XP_054170774.1  serine/threonine-protein kinase tousled-like 2 isoform X16

      UniProtKB/TrEMBL
      B4DUC2

    11. XM_054314787.1 → XP_054170762.1  serine/threonine-protein kinase tousled-like 2 isoform X8

      UniProtKB/Swiss-Prot
      D3DU07, Q86UE8, Q9UKI7, Q9Y4F7
      UniProtKB/TrEMBL
      B4DUC2

    12. XM_054314805.1 → XP_054170780.1  serine/threonine-protein kinase tousled-like 2 isoform X19

      UniProtKB/TrEMBL
      A0A804HJZ9, A0A804HKF1

    13. XM_054314795.1 → XP_054170770.1  serine/threonine-protein kinase tousled-like 2 isoform X13

      UniProtKB/TrEMBL
      B4DUC2

    14. XM_054314801.1 → XP_054170776.1  serine/threonine-protein kinase tousled-like 2 isoform X16

      UniProtKB/TrEMBL
      B4DUC2

    15. XM_054314809.1 → XP_054170784.1  serine/threonine-protein kinase tousled-like 2 isoform X21

      UniProtKB/TrEMBL
      A0A804HK10, A0A804HKF1

    16. XM_054314793.1 → XP_054170768.1  serine/threonine-protein kinase tousled-like 2 isoform X13

      UniProtKB/TrEMBL
      B4DUC2

    17. XM_054314803.1 → XP_054170778.1  serine/threonine-protein kinase tousled-like 2 isoform X18

      UniProtKB/TrEMBL
      A0A804HKF1

    18. XM_054314779.1 → XP_054170754.1  serine/threonine-protein kinase tousled-like 2 isoform X1

      UniProtKB/TrEMBL
      B4DUC2

    19. XM_054314781.1 → XP_054170756.1  serine/threonine-protein kinase tousled-like 2 isoform X3

      UniProtKB/TrEMBL
      B4DUC2

    20. XM_054314783.1 → XP_054170758.1  serine/threonine-protein kinase tousled-like 2 isoform X5

      UniProtKB/TrEMBL
      A0A804HKF1

    21. XM_054314789.1 → XP_054170764.1  serine/threonine-protein kinase tousled-like 2 isoform X9

      UniProtKB/TrEMBL
      A0A804HKF1

    22. XM_054314791.1 → XP_054170766.1  serine/threonine-protein kinase tousled-like 2 isoform X11

      UniProtKB/TrEMBL
      A0A804HKF1

    23. XM_054314797.1 → XP_054170772.1  serine/threonine-protein kinase tousled-like 2 isoform X14

      UniProtKB/TrEMBL
      A0A804HKF1

    24. XM_054314784.1 → XP_054170759.1  serine/threonine-protein kinase tousled-like 2 isoform X6

      UniProtKB/TrEMBL
      B4DUC2

    25. XM_054314790.1 → XP_054170765.1  serine/threonine-protein kinase tousled-like 2 isoform X10

      UniProtKB/TrEMBL
      B4DUC2

    26. XM_054314780.1 → XP_054170755.1  serine/threonine-protein kinase tousled-like 2 isoform X2

      UniProtKB/TrEMBL
      B4DUC2

    27. XM_054314782.1 → XP_054170757.1  serine/threonine-protein kinase tousled-like 2 isoform X4

      UniProtKB/TrEMBL
      B4DUC2

    28. XM_054314798.1 → XP_054170773.1  serine/threonine-protein kinase tousled-like 2 isoform X15

      UniProtKB/TrEMBL
      A0A804HKF1

    29. XM_054314810.1 → XP_054170785.1  serine/threonine-protein kinase tousled-like 2 isoform X22

    30. XM_054314806.1 → XP_054170781.1  serine/threonine-protein kinase tousled-like 2 isoform X20

      UniProtKB/TrEMBL
      B4DUC2

    31. XM_054314807.1 → XP_054170782.1  serine/threonine-protein kinase tousled-like 2 isoform X20

      UniProtKB/TrEMBL
      B4DUC2

    32. XM_054314808.1 → XP_054170783.1  serine/threonine-protein kinase tousled-like 2 isoform X20

      UniProtKB/TrEMBL
      B4DUC2

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001112707.1: Suppressed sequence

      Description
      NM_001112707.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q86UE8.2 GenPept UniProtKB/Swiss-Prot:Q86UE8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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