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    Riok1 RIO kinase 1 [ Mus musculus (house mouse) ]

    Gene ID: 71340, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Riok1provided by MGI
    Official Full Name
    RIO kinase 1provided by MGI
    Primary source
    MGI:MGI:1918590
    See related
    Ensembl:ENSMUSG00000021428 AllianceGenome:MGI:1918590
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ad034; 3110046C13Rik; 5430416A05Rik
    Summary
    This gene encodes a member of the RIO family of atypical serine protein kinases. A similar protein in humans is a component of the protein arginine methyltransferase 5 complex that specifically recruits the RNA-binding protein nucleolin as a methylation substrate. [provided by RefSeq, Feb 2011]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 10.2), CNS E14 (RPKM 8.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Riok1 in Genome Data Viewer
    Location:
    13 A3.3; 13 17.91 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (38220965..38245409)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (38036989..38061433)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:37893604-37893840 Neighboring gene ras responsive element binding protein 1 Neighboring gene predicted gene, 46411 Neighboring gene STARR-positive B cell enhancer ABC_E1461 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:37972487-37972670 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:37974410-37974611 Neighboring gene STARR-seq mESC enhancer starr_34234 Neighboring gene STARR-positive B cell enhancer ABC_E11541 Neighboring gene STARR-positive B cell enhancer ABC_E7227 Neighboring gene STARR-positive B cell enhancer ABC_E10789 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:38086110-38086293 Neighboring gene predicted gene, 52041 Neighboring gene signal sequence receptor, alpha Neighboring gene STARR-positive B cell enhancer ABC_E9396 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:38129215-38129324 Neighboring gene cancer antigen 1 Neighboring gene STARR-seq mESC enhancer starr_34240 Neighboring gene STARR-seq mESC enhancer starr_34241 Neighboring gene STARR-positive B cell enhancer ABC_E3077 Neighboring gene desmoplakin Neighboring gene small nuclear ribonucleoprotein 48 (U11/U12)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Characterisation of tumour-associated antigens in colon cancer. Line A, et al. Cancer Immunol Immunother, 2002 Nov. PMID 12384809, Free PMC Article
    2. RREB1 regulates neuronal proteostasis and the microtubule network. Griffin EN, et al. Sci Adv, 2024 Jan 12. PMID 38198538, Free PMC Article
    3. Targeting posttranslational modifications of RIOK1 inhibits the progression of colorectal and gastric cancers. Hong X, et al. Elife, 2018 Jan 31. PMID 29384474, Free PMC Article
    4. The RIO kinases: an atypical protein kinase family required for ribosome biogenesis and cell cycle progression. LaRonde-LeBlanc N, et al. Biochim Biophys Acta, 2005 Dec 30. PMID 16182620
    5. Decreased expression levels of Ifi genes is associated to the increased resistance to spontaneous arthritis disease in mice deficiency of IL-1RA. Liu X, et al. BMC Immunol, 2016 Aug 2. PMID 27480124, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Describes a function for human RIOK1 as a component of the protein arginine methyltransferase 5 complex, conferring specificity for nucleolin as a methylation substrate.
      Title: RioK1, a new interactor of protein arginine methyltransferase 5 (PRMT5), competes with pICln for binding and modulates PRMT5 complex composition and substrate specificity.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Gene trapped (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC7300

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in maturation of SSU-rRNA IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in maturation of SSU-rRNA IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in maturation of SSU-rRNA ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of rRNA processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ribosomal small subunit biogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of methyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of methyltransferase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of preribosome, small subunit precursor IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of preribosome, small subunit precursor IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of preribosome, small subunit precursor ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein kinase RIO1
    NP_077204.2
    XP_017171095.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_024242.3 → NP_077204.2  serine/threonine-protein kinase RIO1

      See identical proteins and their annotated locations for NP_077204.2

      Status: REVIEWED

      Source sequence(s)
      AK152707, AV370421, CT010477
      Consensus CDS
      CCDS26461.1
      UniProtKB/Swiss-Prot
      Q3U7D5, Q922Q2, Q99LZ1, Q9CU84, Q9CXN9
      Related
      ENSMUSP00000021866.9, ENSMUST00000021866.10
      Conserved Domains (2) summary
      COG1718
      Location:147 → 386
      RIO1; Serine/threonine-protein kinase RIO1 [Signal transduction mechanisms]
      cd05147
      Location:181 → 370
      RIO1_euk; Catalytic domain of the atypical protein serine kinase, Eukaryotic RIO1 kinase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      38220965..38245409
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017315606.2 → XP_017171095.1  serine/threonine-protein kinase RIO1 isoform X1

      Conserved Domains (1) summary
      cd05147
      Location:15 → 204
      RIO1_euk; Catalytic domain of the atypical protein serine kinase, Eukaryotic RIO1 kinase

    RNA

    1. XR_001780817.3 RNA Sequence

    2. XR_382077.4 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q922Q2.2 GenPept UniProtKB/Swiss-Prot:Q922Q2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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