Cd40lg CD40 ligand [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cd40lgprovided by MGI
Official Full Name: CD40 ligandprovided by MGI
Primary source: MGI:MGI:88337
See related: Ensembl:ENSMUSG00000031132 AllianceGenome:MGI:88337
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: IGM; IMD3; Ly62; TRAP; gp39; CD154; Cd40l; HIGM1; Ly-62; T-BAM; CD40-L; Tnfsf5; Tnlg8b
Summary: Predicted to enable protein serine/threonine kinase activator activity and signaling receptor binding activity. Involved in isotype switching. Acts upstream of or within B cell differentiation and regulation of immunoglobulin production. Located in external side of plasma membrane. Is expressed in Meckel's cartilage; dorsal root ganglion; and limb. Used to study inflammatory bowel disease and systemic lupus erythematosus. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; artery disease (multiple); autoimmune disease (multiple); combined T cell and B cell immunodeficiency (multiple); and hematologic cancer (multiple). Orthologous to human CD40LG (CD40 ligand). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in thymus adult (RPKM 2.5), mammary gland adult (RPKM 1.2) and 4 other tissues See more
Orthologs: human all
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Genomic context

Location:: X A6; X 31.21 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (56257448..56269402)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (57212143..57224042)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The aged microenvironment impairs BCL6 and CD40L induction in CD4[+] T follicular helper cell differentiation.
Title: The aged microenvironment impairs BCL6 and CD40L induction in CD4(+) T follicular helper cell differentiation.
B cells in the pneumococcus-infected lung are heterogeneous and require CD4[+] T cell help including CD40L to become resident memory B cells.
Title: B cells in the pneumococcus-infected lung are heterogeneous and require CD4(+) T cell help including CD40L to become resident memory B cells.
CD40L modulates CD4[+] T-cell activation through receptor for activated C kinase 1.
Title: CD40L modulates CD4(+) T-cell activation through receptor for activated C kinase 1.
CD40-CD40 ligand interaction between periodontal ligament cells and cementoblasts enhances periodontal tissue remodeling in response to mechanical stress.
Title: CD40-CD40 ligand interaction between periodontal ligament cells and cementoblasts enhances periodontal tissue remodeling in response to mechanical stress.
Importance of CD40/CD40 dyad in the course of infection with Trypanosoma cruzi: Impact of its inhibition.
Title: Importance of CD40/CD40 dyad in the course of infection with Trypanosoma cruzi: Impact of its inhibition.
Platelets control liver tumor growth through P2Y12-dependent CD40L release in NAFLD.
Title: Platelets control liver tumor growth through P2Y12-dependent CD40L release in NAFLD.
Synergistic antitumor response with recombinant modified virus Ankara armed with CD40L and CD137L against peritoneal carcinomatosis.
Title: Synergistic antitumor response with recombinant modified virus Ankara armed with CD40L and CD137L against peritoneal carcinomatosis.
3-hydroxy butyrate dehydrogenase 2 deficiency aggravates systemic lupus erythematosus progression in a mouse model by promoting CD40 ligand demethylation.
Title: 3-hydroxy butyrate dehydrogenase 2 deficiency aggravates systemic lupus erythematosus progression in a mouse model by promoting CD40 ligand demethylation.
CD40L modulates transcriptional signatures of neutrophils in the bone marrow associated with development and trafficking.
Title: CD40L modulates transcriptional signatures of neutrophils in the bone marrow associated with development and trafficking.
Downregulation of CD40L-CD40 attenuates seizure susceptibility and severity of seizures.
Title: Downregulation of CD40L-CD40 attenuates seizure susceptibility and severity of seizures.

Submit: New GeneRIF Correction See all GeneRIFs (182)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1)
Endonuclease-mediated (5) 1 citation
Targeted (6) 1 citation

General gene information

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Markers

NoName (e-PCR)
- UniSTS:491368

PMC164515P3 (e-PCR)
- UniSTS:271490

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables CD40 receptor binding	ISO Inferred from Sequence Orthology more info
enables CD40 receptor binding	ISS Inferred from Sequence or Structural Similarity more info
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables cytokine activity	IEA Inferred from Electronic Annotation more info
enables integrin binding	IEA Inferred from Electronic Annotation more info
enables integrin binding	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine kinase activator activity	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine kinase activator activity	ISS Inferred from Sequence or Structural Similarity more info
enables tumor necrosis factor receptor binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within B cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in B cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in B cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in CD40 signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in CD40 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cell surface receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in dendritic cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within immunoglobulin production	IGI Inferred from Genetic Interaction more info	PubMed
involved_in inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in inflammatory response	ISS Inferred from Sequence or Structural Similarity more info
involved_in integrin-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in integrin-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in isotype switching	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in platelet activation	ISO Inferred from Sequence Orthology more info
involved_in platelet activation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of B cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MHC class II biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of NF-kappaB transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of canonical NF-kappaB signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of dendritic cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endothelial cell apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of endothelial cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of extrinsic apoptotic signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of immune response to tumor cell	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-10 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-10 production	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of interleukin-12 production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of interleukin-12 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-4 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-4 production	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of type II interferon production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of immunoglobulin production	IDA Inferred from Direct Assay more info	PubMed
involved_in signal transduction	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in cell body	ISO Inferred from Sequence Orthology more info
located_in cell projection	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: CD40 ligand

Names: T-cell antigen Gp39; TNF-related activation protein; tumor necrosis factor ligand 8b; tumor necrosis factor ligand superfamily member 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_011616.3 → NP_035746.2 CD40 ligand

Status: VALIDATED

Source sequence(s)

AL672128

Consensus CDS

CCDS30152.1

UniProtKB/Swiss-Prot

P27548

UniProtKB/TrEMBL

Q0VEI3

Related

ENSMUSP00000033466.2, ENSMUST00000033466.2

Conserved Domains (1) summary

pfam00229
Location:137 → 260

TNF; TNF(Tumour Necrosis Factor) family