Txnl1 thioredoxin-like 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Txnl1provided by MGI
Official Full Name: thioredoxin-like 1provided by MGI
Primary source: MGI:MGI:1860078
See related: Ensembl:ENSMUSG00000024583 AllianceGenome:MGI:1860078
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Txnl; 32kDa; TRP32
Summary: Predicted to enable protein-disulfide reductase activity. Predicted to be located in cytoplasm. Predicted to be part of proteasome complex. Predicted to be active in cytosol. Is expressed in several structures, including adrenal gland; alimentary system; brain; genitourinary system; and immune system. Orthologous to human TXNL1 (thioredoxin like 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in placenta adult (RPKM 33.3), liver E14 (RPKM 29.9) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 18 E1; 18 37.06 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	18	NC_000084.7 (63795872..63825535, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	18	NC_000084.6 (63662801..63692359, complement)

Chromosome 18 - NC_000084.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TRP32 was identified as a novel subunit of the 26 S proteasome.
Title: Thioredoxin-related Protein 32 is an arsenite-regulated Thiol Reductase of the proteasome 19 S particle.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Gene trapped (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH125726 (e-PCR)
- UniSTS:162485

NoName (e-PCR)
- UniSTS:237822

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables disulfide oxidoreductase activity	ISO Inferred from Sequence Orthology more info
enables protein-disulfide reductase activity	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of proteasome complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: thioredoxin-like protein 1

Names: 32 kDa thioredoxin-related protein; thioredoxin-like (32kD); thioredoxin-related protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_016792.4 → NP_058072.2 thioredoxin-like protein 1

See identical proteins and their annotated locations for NP_058072.2

Status: PROVISIONAL

Source sequence(s)

AC102040

Consensus CDS

CCDS29297.1

UniProtKB/Swiss-Prot

O70379, Q3TI92, Q8CDN6

UniProtKB/TrEMBL

Q3U8R9

Related

ENSMUSP00000158375.2, ENSMUST00000237004.2

Conserved Domains (2) summary

cd02947
Location:12 → 104

TRX_family; TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox ...

pfam06201
Location:128 → 268

PITH; PITH domain