Slc5a9 solute carrier family 5 (sodium/glucose cotransporter), member 9 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc5a9provided by MGI
Official Full Name: solute carrier family 5 (sodium/glucose cotransporter), member 9provided by MGI
Primary source: MGI:MGI:2140201
See related: Ensembl:ENSMUSG00000028544 AllianceGenome:MGI:2140201
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: SGLT4
Summary: Predicted to enable D-glucose:sodium symporter activity. Predicted to be involved in sodium ion transport and transmembrane transport. Predicted to be active in plasma membrane. Orthologous to human SLC5A9 (solute carrier family 5 member 9). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in kidney adult (RPKM 7.9), thymus adult (RPKM 7.5) and 7 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 D1; 4 51.53 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (111732571..111759993, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (111875374..111902796, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SGLT4 would have unique physiological functions (i.e., absorption and/or reabsorption of Man, 1,5AG, and Fru, in addition to Glc).
Title: SLC5A9/SGLT4, a new Na+-dependent glucose transporter, is an essential transporter for mannose, 1,5-anhydro-D-glucitol, and fructose.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (1)

General gene information

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Markers

AI159731 (e-PCR)
- UniSTS:159271

D4Mit199 (e-PCR), detects polymorphism
- UniSTS:116299

Slc5a9 (e-PCR), detects polymorphism
- UniSTS:546016

Slc5a9 (e-PCR), detects polymorphism
- UniSTS:546017

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables D-glucose:sodium symporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables symporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in sodium ion transport	IEA Inferred from Electronic Annotation more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: sodium/glucose cotransporter 4

Names: Na(+)/glucose cotransporter 4; mSGLT4; solute carrier family 5 member 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_145551.4 → NP_663526.3 sodium/glucose cotransporter 4

Status: VALIDATED

Source sequence(s)

AI159731, AK028743, AK029158, AK033425

Consensus CDS

CCDS18474.1

UniProtKB/Swiss-Prot

Q8BGU9, Q8BZW1, Q8VDT1

Related

ENSMUSP00000099782.2, ENSMUST00000102721.8

Conserved Domains (1) summary

cl00456
Location:45 → 685

SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

111732571..111759993 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006503000.3 → XP_006503063.1 sodium/glucose cotransporter 4 isoform X1

UniProtKB/Swiss-Prot

Q8BGU9, Q8BZW1, Q8VDT1

Related

ENSMUSP00000099780.2, ENSMUST00000102719.8

Conserved Domains (1) summary

cl00456
Location:45 → 685

SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
XM_006503001.2 → XP_006503064.1 sodium/glucose cotransporter 4 isoform X2

Conserved Domains (1) summary

cl00456
Location:1 → 593

SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
XM_006503002.4 → XP_006503065.1 sodium/glucose cotransporter 4 isoform X3

Conserved Domains (1) summary

cl00456
Location:45 → 377

SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain