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    Mpped2 metallophosphoesterase domain containing 2 [ Mus musculus (house mouse) ]

    Gene ID: 77015, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Mpped2provided by MGI
    Official Full Name
    metallophosphoesterase domain containing 2provided by MGI
    Primary source
    MGI:MGI:1924265
    See related
    Ensembl:ENSMUSG00000016386 AllianceGenome:MGI:1924265
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    239Fb; 2700082O15Rik
    Summary
    Predicted to enable manganese ion binding activity; phosphoric diester hydrolase activity; and purine ribonucleotide binding activity. Is expressed in axial skeleton; head mesenchyme; midbrain ventricular layer; telencephalon; and thyroid cartilage. Orthologous to human MPPED2 (metallophosphoesterase domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in CNS E14 (RPKM 10.1), whole brain E14.5 (RPKM 7.9) and 14 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mpped2 in Genome Data Viewer
    Location:
    2 E3; 2 55.8 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (106523526..106699684)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (106693181..106868361)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_05325 Neighboring gene predicted gene, 36544 Neighboring gene STARR-seq mESC enhancer starr_05326 Neighboring gene expressed sequence BB218582 Neighboring gene STARR-seq mESC enhancer starr_05327 Neighboring gene predicted gene, 29885 Neighboring gene RIKEN cDNA C130023O10 gene Neighboring gene predicted gene, 22813 Neighboring gene predicted gene, 54139 Neighboring gene high mobility group box 2 pseudogene Neighboring gene predicted gene, 39902

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Characterization of a novel gene adjacent to PAX6, revealing synteny conservation with functional significance. Kleinjan DA, et al. Mamm Genome, 2002 Feb. PMID 11889558
    2. Analysis of Pax6 contiguous gene deletions in the mouse, Mus musculus, identifies regions distinct from Pax6 responsible for extreme small-eye and belly-spotting phenotypes. Favor J, et al. Genetics, 2009 Aug. PMID 19474196, Free PMC Article
    3. Single-cell transcriptomics of the early developing mouse cerebral cortex disentangle the spatial and temporal components of neuronal fate acquisition. Moreau MX, et al. Development, 2021 Jul 15. PMID 34170322
    4. Transcriptional heterogeneity of ventricular zone cells in the ganglionic eminences of the mouse forebrain. Lee DR, et al. Elife, 2022 Feb 17. PMID 35175194, Free PMC Article
    5. A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome. Mural RJ, et al. Science, 2002 May 31. PMID 12040188

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables AMP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables AMP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables GMP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables GMP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables manganese ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables manganese ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables phosphoric diester hydrolase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphoric diester hydrolase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    metallophosphoesterase MPPED2
    Names
    metallophosphoesterase domain-containing protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001143683.2 → NP_001137155.1  metallophosphoesterase MPPED2 isoform a

      See identical proteins and their annotated locations for NP_001137155.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1, 2, and 3 all encode the same isoform (a).
      Source sequence(s)
      AL512587, AL773516
      Consensus CDS
      CCDS50654.1
      UniProtKB/Swiss-Prot
      Q9CZJ0
      UniProtKB/TrEMBL
      B1APT1, B1APT2
      Related
      ENSMUSP00000106692.2, ENSMUST00000111063.8
      Conserved Domains (1) summary
      cd07379
      Location:59 → 271
      MPP_239FB; Homo sapiens 239FB and related proteins, metallophosphatase domain

    2. NM_001356554.1 → NP_001343483.1  metallophosphoesterase MPPED2 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 all encode the same isoform (a).
      Source sequence(s)
      AL512587, AL773516
      Consensus CDS
      CCDS50654.1
      UniProtKB/Swiss-Prot
      Q9CZJ0
      UniProtKB/TrEMBL
      B1APT1, B1APT2
      Conserved Domains (1) summary
      cd07379
      Location:59 → 271
      MPP_239FB; Homo sapiens 239FB and related proteins, metallophosphatase domain

    3. NM_001356555.1 → NP_001343484.1  metallophosphoesterase MPPED2 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a.
      Source sequence(s)
      AL512587, AL773516
      Conserved Domains (1) summary
      cd07379
      Location:72 → 145
      MPP_239FB; Homo sapiens 239FB and related proteins, metallophosphatase domain

    4. NM_029837.1 → NP_084113.1  metallophosphoesterase MPPED2 isoform a

      See identical proteins and their annotated locations for NP_084113.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 all encode the same isoform (a).
      Source sequence(s)
      AK012553, AK165186, AV230002
      Consensus CDS
      CCDS50654.1
      UniProtKB/Swiss-Prot
      Q9CZJ0
      UniProtKB/TrEMBL
      B1APT1, B1APT2
      Related
      ENSMUSP00000016530.8, ENSMUST00000016530.14
      Conserved Domains (1) summary
      cd07379
      Location:59 → 271
      MPP_239FB; Homo sapiens 239FB and related proteins, metallophosphatase domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      106523526..106699684
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030252204.1 → XP_030108064.1  metallophosphoesterase MPPED2 isoform X1

    2. XM_011239842.4 → XP_011238144.1  metallophosphoesterase MPPED2 isoform X3

      See identical proteins and their annotated locations for XP_011238144.1

      Conserved Domains (1) summary
      cd07379
      Location:72 → 145
      MPP_239FB; Homo sapiens 239FB and related proteins, metallophosphatase domain

    3. XM_030252205.2 → XP_030108065.1  metallophosphoesterase MPPED2 isoform X2

      UniProtKB/TrEMBL
      B1APT1
      Conserved Domains (1) summary
      cd07379
      Location:26 → 238
      MPP_239FB; Homo sapiens 239FB and related proteins, metallophosphatase domain

    4. XM_006500394.5 → XP_006500457.1  metallophosphoesterase MPPED2 isoform X3

      See identical proteins and their annotated locations for XP_006500457.1

      Conserved Domains (1) summary
      cd07379
      Location:72 → 145
      MPP_239FB; Homo sapiens 239FB and related proteins, metallophosphatase domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CZJ0.1 GenPept UniProtKB/Swiss-Prot:Q9CZJ0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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