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    Fdps farnesyl diphosphate synthetase [ Mus musculus (house mouse) ]

    Gene ID: 110196, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Fdpsprovided by MGI
    Official Full Name
    farnesyl diphosphate synthetaseprovided by MGI
    Primary source
    MGI:MGI:104888
    See related
    Ensembl:ENSMUSG00000059743 AllianceGenome:MGI:104888
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fdpsl1; mKIAA1293; 6030492I17Rik
    Summary
    Predicted to enable dimethylallyltranstransferase activity and geranyltranstransferase activity. Predicted to be involved in farnesyl diphosphate biosynthetic process; positive regulation of cell growth involved in cardiac muscle cell development; and positive regulation of cholesterol biosynthetic process. Located in mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in porokeratosis. Orthologous to human FDPS (farnesyl diphosphate synthase). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in liver E18 (RPKM 129.0), liver adult (RPKM 110.9) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Fdps in Genome Data Viewer
    Location:
    3 F1; 3 39.01 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (89000895..89009274, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (89093588..89101967, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene ASH1 like histone lysine methyltransferase Neighboring gene predicted gene, 24403 Neighboring gene STARR-seq mESC enhancer starr_08223 Neighboring gene STARR-positive B cell enhancer ABC_E1623 Neighboring gene STARR-positive B cell enhancer ABC_E2078 Neighboring gene RUN and SH3 domain containing 1 Neighboring gene predicted gene, 22935 Neighboring gene STARR-seq mESC enhancer starr_08224 Neighboring gene predicted gene, 29704 Neighboring gene pyruvate kinase liver and red blood cell Neighboring gene hyperpolarization-activated, cyclic nucleotide-gated K+ 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Cardiac-specific deletion of FDPS induces cardiac remodeling and dysfunction by enhancing the activity of small GTP-binding proteins. Wang X, et al. J Pathol, 2021 Dec. PMID 34467534
    2. Cardiac-specific overexpression of farnesyl pyrophosphate synthase induces cardiac hypertrophy and dysfunction in mice. Yang J, et al. Cardiovasc Res, 2013 Mar 1. PMID 23180723
    3. Overexpression of farnesyl pyrophosphate synthase increases myocardial ischemia/reperfusion injury in mice. Dai D, et al. Gene, 2018 Sep 25. PMID 29864496
    4. Transcriptional regulation of farnesyl pyrophosphate synthase by liver X receptors. Fukuchi J, et al. Steroids, 2003 Sep. PMID 12957674
    5. A novel role for farnesyl pyrophosphate synthase in fibroblast growth factor-mediated signal transduction. Reilly JF, et al. Biochem J, 2002 Sep 1. PMID 12020352, Free PMC Article

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Farnesyl diphosphate synthase exacerbates nonalcoholic steatohepatitis via the activation of AHR-CD36 axis.
      Title: Farnesyl diphosphate synthase exacerbates nonalcoholic steatohepatitis via the activation of AHR-CD36 axis.
    2. Overexpression of FPPS aggravates myocardial ischemia/reperfusion injury in mice.
      Title: Overexpression of farnesyl pyrophosphate synthase increases myocardial ischemia/reperfusion injury in mice.
    3. Farnesyl pyrophosphate synthase (FPPS) may function as a potent regulator in myocardial remodelling. The FPPS-regulated signalling pathway is relevant to the pathological changes in cardiac hypertrophy and heart failure.
      Title: Cardiac-specific overexpression of farnesyl pyrophosphate synthase induces cardiac hypertrophy and dysfunction in mice.
    4. identified a single putative direct repeat 4 (DR4) LXR response element in the FPS promoter isolated from immortalized murine astrocyte P11-5 cells
      Title: Transcriptional regulation of farnesyl pyrophosphate synthase by liver X receptors.
    5. novel role in fibroblast growth factor-mediated signal transduction
      Title: A novel role for farnesyl pyrophosphate synthase in fibroblast growth factor-mediated signal transduction.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC107162

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables dimethylallyltranstransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dimethylallyltranstransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables geranyltranstransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables geranyltranstransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables geranyltranstransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cholesterol biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in farnesyl diphosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in farnesyl diphosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in farnesyl diphosphate biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in geranyl diphosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of cell growth involved in cardiac muscle cell development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cholesterol biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in peroxisome ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    farnesyl pyrophosphate synthase
    Names
    (2E,6E)-farnesyl diphosphate synthase
    CR 39
    FPP synthase
    FPP synthetase
    FPS
    cholesterol-regulated 39 kDa protein
    dimethylallyltranstransferase
    farnesyl diphosphate synthase
    farnesyl pyrophosphate synthetase
    geranyltranstransferase
    NP_001240680.1
    NP_608219.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001253751.1 → NP_001240680.1  farnesyl pyrophosphate synthase isoform 1

      See identical proteins and their annotated locations for NP_001240680.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC140468, BC048497, BE994006, BY144580, CJ082322
      UniProtKB/TrEMBL
      Q3TMB3, Q3US29, Q5M8R9
      Conserved Domains (2) summary
      pfam00348
      Location:117 → 378
      polyprenyl_synt; Polyprenyl synthetase
      pfam07462
      Location:72 → 144
      MSP1_C; Merozoite surface protein 1 (MSP1) C-terminus

    2. NM_134469.4 → NP_608219.1  farnesyl pyrophosphate synthase isoform 2

      See identical proteins and their annotated locations for NP_608219.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      BC048497, BE994006, CJ082244
      Consensus CDS
      CCDS17488.1
      UniProtKB/Swiss-Prot
      Q920E5
      UniProtKB/TrEMBL
      Q3TMB3, Q3US29, Q4FJN9, Q5M8R9
      Related
      ENSMUSP00000080531.9, ENSMUST00000081848.13
      Conserved Domains (1) summary
      pfam00348
      Location:50 → 311
      polyprenyl_synt; Polyprenyl synthetase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      89000895..89009274 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_180985.1: Suppressed sequence

      Description
      NM_180985.1: This RefSeq record was removed by NCBI staff. Contact [email protected] for further information.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q920E5.1 GenPept UniProtKB/Swiss-Prot:Q920E5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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