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    Gpn1 GPN-loop GTPase 1 [ Mus musculus (house mouse) ]

    Gene ID: 74254, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Gpn1provided by MGI
    Official Full Name
    GPN-loop GTPase 1provided by MGI
    Primary source
    MGI:MGI:1921504
    See related
    Ensembl:ENSMUSG00000064037 AllianceGenome:MGI:1921504
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Xab1; MBDIN; NTPBP; 2410004J02Rik
    Summary
    Predicted to enable GTPase activity. Predicted to be located in cytosol; mitochondrion; and nucleoplasm. Is expressed in embryo; sublingual gland primordium; and submandibular gland primordium. Orthologous to human GPN1 (GPN-loop GTPase 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 11.8), CNS E14 (RPKM 10.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Gpn1 in Genome Data Viewer
    Location:
    5 B1; 5 17.27 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (31652085..31670250)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (31494741..31512904)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_12770 Neighboring gene zinc finger protein 512 Neighboring gene STARR-seq mESC enhancer starr_12771 Neighboring gene coiled-coil domain containing 121 Neighboring gene STARR-positive B cell enhancer ABC_E6315 Neighboring gene STARR-seq mESC enhancer starr_12772 Neighboring gene SPT7-like, STAGA complex gamma subunit Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:31829068-31829342 Neighboring gene solute carrier family 4 (anion exchanger), member 1, adaptor protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. MBDin, a novel MBD2-interacting protein, relieves MBD2 repression potential and reactivates transcription from methylated promoters. Lembo F, et al. Mol Cell Biol, 2003 Mar. PMID 12588985, Free PMC Article
    2. ALS-linked loss of Cyclin-F function affects HSP90. Siebert A, et al. Life Sci Alliance, 2022 Sep 16. PMID 36114006, Free PMC Article
    3. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
    4. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
    5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    GPN-loop GTPase 1
    Names
    MBD2-interacting protein
    XPA binding protein 1
    methyl-CpG binding domain protein 2 interacting protein
    NP_598517.1
    XP_006504224.1
    XP_006504225.1
    XP_011239076.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133756.6 → NP_598517.1  GPN-loop GTPase 1

      See identical proteins and their annotated locations for NP_598517.1

      Status: VALIDATED

      Source sequence(s)
      AC113276
      Consensus CDS
      CCDS19185.1
      UniProtKB/Swiss-Prot
      Q8VCE2
      UniProtKB/TrEMBL
      Q4VAB2
      Related
      ENSMUSP00000076217.7, ENSMUST00000076949.13
      Conserved Domains (2) summary
      COG1100
      Location:20 → 229
      Gem1; GTPase SAR1 family domain [General function prediction only]
      pfam03029
      Location:24 → 261
      ATP_bind_1; Conserved hypothetical ATP binding protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      31652085..31670250
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006504162.3 → XP_006504225.1  GPN-loop GTPase 1 isoform X2

      See identical proteins and their annotated locations for XP_006504225.1

      Conserved Domains (1) summary
      cd17870
      Location:1 → 180
      GPN1; GPN-loop GTPase 1

    2. XM_006504161.5 → XP_006504224.1  GPN-loop GTPase 1 isoform X1

      Conserved Domains (1) summary
      cd17870
      Location:2 → 223
      GPN1; GPN-loop GTPase 1

    3. XM_011240774.4 → XP_011239076.1  GPN-loop GTPase 1 isoform X2

      See identical proteins and their annotated locations for XP_011239076.1

      Conserved Domains (1) summary
      cd17870
      Location:1 → 180
      GPN1; GPN-loop GTPase 1
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VCE2.1 GenPept UniProtKB/Swiss-Prot:Q8VCE2

    Gene LinkOut

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