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    Ssmem1 serine-rich single-pass membrane protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 75647, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ssmem1provided by MGI
    Official Full Name
    serine-rich single-pass membrane protein 1provided by MGI
    Primary source
    MGI:MGI:1922897
    See related
    Ensembl:ENSMUSG00000029784 AllianceGenome:MGI:1922897
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1700016K02Rik; 1700025E21Rik
    Summary
    Orthologous to human SSMEM1 (serine rich single-pass membrane protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward testis adult (RPKM 30.5) See more
    Orthologs
    human all
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    Genomic context

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    See Ssmem1 in Genome Data Viewer
    Location:
    6 A3.3; 6 12.52 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (30509790..30520253)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (30509791..30520254)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700012C14 gene Neighboring gene transmembrane protein 209 Neighboring gene STARR-seq mESC enhancer starr_15468 Neighboring gene predicted gene, 53278 Neighboring gene carboxypeptidase A2, pancreatic Neighboring gene carboxypeptidase A4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Knockout of serine-rich single-pass membrane protein 1 (Ssmem1) causes globozoospermia and sterility in male mice†. Nozawa K, et al. Biol Reprod, 2020 Aug 4. PMID 32301969, Free PMC Article
    2. Identification and integrative analysis of 28 novel genes specifically expressed and developmentally regulated in murine spermatogenic cells. Hong S, et al. J Biol Chem, 2005 Mar 4. PMID 15613475
    3. Mutagenesis of diploid mammalian genes by gene entrapment. Lin Q, et al. Nucleic Acids Res, 2006. PMID 17062627, Free PMC Article
    4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Knockout of serine-rich single-pass membrane protein 1 (Ssmem1) causes globozoospermia and sterility in male micedagger.
      Title: Knockout of serine-rich single-pass membrane protein 1 (Ssmem1) causes globozoospermia and sterility in male mice†.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    serine-rich single-pass membrane protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_027073.1 → NP_081349.1  serine-rich single-pass membrane protein 1 isoform a

      See identical proteins and their annotated locations for NP_081349.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript but encodes the shorter isoform (a).
      Source sequence(s)
      AC155848, AK006038
      Consensus CDS
      CCDS57417.1
      UniProtKB/TrEMBL
      Q9DAA0
      Related
      ENSMUSP00000031797.5, ENSMUST00000031797.11
      Conserved Domains (1) summary
      pfam15468
      Location:1 → 195
      DUF4636; Domain of unknown function (DUF4636)

    2. NM_029373.4 → NP_083649.1  serine-rich single-pass membrane protein 1 isoform b

      See identical proteins and their annotated locations for NP_083649.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate exon in the 5' UTR and 5' coding region, compared to variant 1. It encodes isoform b which is longer and has a distinct N-terminus, compared to isoform a.
      Source sequence(s)
      AC155848, AK006038, AK006332, BU938696
      Consensus CDS
      CCDS19973.1
      UniProtKB/TrEMBL
      Q9D9Y8
      Related
      ENSMUSP00000031798.8, ENSMUST00000031798.14
      Conserved Domains (1) summary
      pfam15468
      Location:1 → 243
      DUF4636; Domain of unknown function (DUF4636)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      30509790..30520253
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006505195.4 → XP_006505258.1  serine-rich single-pass membrane protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006505258.1

      UniProtKB/TrEMBL
      Q78FQ7
      Conserved Domains (1) summary
      pfam15468
      Location:1 → 182
      DUF4636; Domain of unknown function (DUF4636)

    2. XM_006505194.4 → XP_006505257.1  serine-rich single-pass membrane protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006505257.1

      UniProtKB/TrEMBL
      Q78FQ7
      Conserved Domains (1) summary
      pfam15468
      Location:1 → 182
      DUF4636; Domain of unknown function (DUF4636)

    3. XM_017321817.1 → XP_017177306.1  serine-rich single-pass membrane protein 1 isoform X1

      UniProtKB/TrEMBL
      Q78FQ7
      Conserved Domains (1) summary
      pfam15468
      Location:1 → 182
      DUF4636; Domain of unknown function (DUF4636)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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