Akr7a5 aldo-keto reductase family 7, member A5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Akr7a5provided by MGI
Official Full Name: aldo-keto reductase family 7, member A5provided by MGI
Primary source: MGI:MGI:107796
See related: Ensembl:ENSMUSG00000028743 AllianceGenome:MGI:107796
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Afar; Afar1; Akr7a2; 0610025K21Rik
Summary: Predicted to enable aldose reductase (NADPH) activity; identical protein binding activity; and phenanthrene-9,10-epoxide hydrolase activity. Predicted to be involved in lipid metabolic process. Located in mitochondrion. Is expressed in cerebral cortex ventricular layer. Orthologous to several human genes including AKR7A2 (aldo-keto reductase family 7 member A2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in duodenum adult (RPKM 97.0), kidney adult (RPKM 73.4) and 19 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 D3; 4 70.64 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (139038005..139046097)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (139310720..139318786)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

AKR7A5 knockout promote acute liver injury by inducing inflammatory response, oxidative stress and apoptosis in mice.
Title: AKR7A5 knockout promote acute liver injury by inducing inflammatory response, oxidative stress and apoptosis in mice.
These findings indicate the importance of AKR7A5 in protecting cells from the damaging effects of oxidative stress, and that this cytoprotective function is carried out through multiple pathways.
Title: Aldo-keto reductase 7A5 (AKR7A5) attenuates oxidative stress and reactive aldehyde toxicity in V79-4 cells.
AKR7A5 has selective substrate specificity towards naphthoquinone derivatives, suggesting that the aldo-keto reductase could play an important role in metabolism of certain naphthoquinone derivatives.
Title: [Purification of recombinant AKR7A5 protein and measurement of substrate specificity of AKR7A5 towards naphthoquinone and its derivatives].
AKR7A isozymes may be important in protecting against toxic aldehydes derived from lipid peroxidation in vivo
Title: Mouse aldo-keto reductase AKR7A5 protects V79 cells against 4-hydroxynonenal-induced apoptosis.
structure and tissue-related expression of AFAR genes
Title: Aflatoxin B1 aldehyde reductase (AFAR) genes cluster at 1p35-1p36.1 in a region frequently altered in human tumour cells.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Afar (e-PCR), detects polymorphism
- UniSTS:141046

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables aldo-keto reductase (NADPH) activity	IBA Inferred from Biological aspect of Ancestor more info
enables aldose reductase (NADPH) activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables phenanthrene-9,10-epoxide hydrolase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in lipid metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	HDA more info	PubMed
located_in nuclear envelope	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: aflatoxin B1 aldehyde reductase member 2

Names: SSA reductase; aldo-keto reductase family 7, member A5 (aflatoxin aldehyde reductase); succinic semialdehyde reductase

NP_079613.3

EC 1.1.1.n11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_025337.3 → NP_079613.3 aflatoxin B1 aldehyde reductase member 2

See identical proteins and their annotated locations for NP_079613.3

Status: VALIDATED

Source sequence(s)

AK143203, BE652423

Consensus CDS

CCDS18844.1

UniProtKB/Swiss-Prot

A2AMV3, Q3UPU2, Q8CG76, Q8CG77, Q8JZQ8, Q9D157

Related

ENSMUSP00000073459.7, ENSMUST00000073787.7

Conserved Domains (2) summary

cd06660
Location:46 → 354

Aldo_ket_red; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial ...

COG0667
Location:46 → 363

Tas; Predicted oxidoreductase (related to aryl-alcohol dehydrogenase) [General function prediction only]