Il17ra interleukin 17 receptor A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Il17raprovided by MGI
Official Full Name: interleukin 17 receptor Aprovided by MGI
Primary source: MGI:MGI:107399
See related: Ensembl:ENSMUSG00000002897 AllianceGenome:MGI:107399
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Il17r; Cdw217; VDw217
Summary: Enables interleukin-17 receptor activity and signaling receptor binding activity. Involved in several processes, including T-helper 17 type immune response; interleukin-17-mediated signaling pathway; and positive regulation of cytokine production involved in inflammatory response. Acts upstream of or within positive regulation of interleukin-13 production and positive regulation of interleukin-5 production. Located in plasma membrane. Is expressed in thymus primordium. Human ortholog(s) of this gene implicated in immunodeficiency 51. Orthologous to human IL17RA (interleukin 17 receptor A). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in thymus adult (RPKM 57.0), spleen adult (RPKM 39.4) and 19 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 F1; 6 56.95 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (120440143..120460692)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (120463181..120483731)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Decreased interleukin-17RA expression is associated with good prognosis in patients with colorectal cancer and inhibits tumor growth and vascularity in mice.
Title: Decreased interleukin-17RA expression is associated with good prognosis in patients with colorectal cancer and inhibits tumor growth and vascularity in mice.
Increased levels and activation of the IL-17 receptor in microglia contribute to enhanced neuroinflammation in cerebellum of hyperammonemic rats.
Title: Increased levels and activation of the IL-17 receptor in microglia contribute to enhanced neuroinflammation in cerebellum of hyperammonemic rats.
IL-17RA-Mediated Epithelial Cell Activity Prevents Severe Inflammatory Response to Helicobacter pylori Infection.
Title: IL-17RA-Mediated Epithelial Cell Activity Prevents Severe Inflammatory Response to Helicobacter pylori Infection.
IL-17RA promotes pathologic epithelial inflammation in a mouse model of upper respiratory influenza infection.
Title: IL-17RA promotes pathologic epithelial inflammation in a mouse model of upper respiratory influenza infection.
IL-17-driven induction of Paneth cell antimicrobial functions protects the host from microbiota dysbiosis and inflammation in the ileum.
Title: IL-17-driven induction of Paneth cell antimicrobial functions protects the host from microbiota dysbiosis and inflammation in the ileum.
Ets1 and IL17RA cooperate to regulate autoimmune responses and skin immunity to Staphylococcus aureus.
Title: Ets1 and IL17RA cooperate to regulate autoimmune responses and skin immunity to Staphylococcus aureus.
IL-17-induced dimerization of IL-17RA drives the formation of the IL-17 signalosome to potentiate signaling.
Title: IL-17-induced dimerization of IL-17RA drives the formation of the IL-17 signalosome to potentiate signaling.
IL-17 Receptor Signaling through IL-17A or IL-17F Is Sufficient to Maintain Innate Response and Control of Helicobacter pylori Immunopathogenesis.
Title: IL-17 Receptor Signaling through IL-17A or IL-17F Is Sufficient to Maintain Innate Response and Control of Helicobacter pylori Immunopathogenesis.
Mucosal fungi promote gut barrier function and social behavior via Type 17 immunity.
Title: Mucosal fungi promote gut barrier function and social behavior via Type 17 immunity.
IL-17RA-signaling in Lgr5(+) intestinal stem cells induces expression of transcription factor ATOH1 to promote secretory cell lineage commitment.
Title: IL-17RA-signaling in Lgr5(+) intestinal stem cells induces expression of transcription factor ATOH1 to promote secretory cell lineage commitment.

Submit: New GeneRIF Correction See all GeneRIFs (76)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (9) 1 citation
Targeted (9) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI132377 (e-PCR)
- UniSTS:208027

AW538159 (e-PCR)
- UniSTS:179451

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables interleukin-17 receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables interleukin-17 receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables interleukin-17 receptor activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in T-helper 17 type immune response	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to cytokine stimulus	ISO Inferred from Sequence Orthology more info
involved_in defense response to fungus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in fibroblast activation	IEA Inferred from Electronic Annotation more info
involved_in fibroblast activation	ISO Inferred from Sequence Orthology more info
involved_in granulocyte chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in interleukin-17-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in interleukin-17-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in interleukin-17A-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in interleukin-17A-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of chemokine (C-X-C motif) ligand 1 production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of chemokine (C-X-C motif) ligand 1 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytokine production involved in inflammatory response	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of cytokine production involved in inflammatory response	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of cytokine production involved in inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of inflammatory response	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of interleukin-13 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of interleukin-23 production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of interleukin-23 production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of interleukin-5 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of interleukin-6 production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of interleukin-6 production	ISO Inferred from Sequence Orthology more info
involved_in protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in response to virus	IDA Inferred from Direct Assay more info	PubMed
involved_in response to virus	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: interleukin-17 receptor A

Names: IL-17 receptor A; IL-17RA

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008359.2 → NP_032385.1 interleukin-17 receptor A precursor

See identical proteins and their annotated locations for NP_032385.1

Status: VALIDATED

Source sequence(s)

AK080226, BY267308, U31993

Consensus CDS

CCDS20482.1

UniProtKB/Swiss-Prot

Q60943

Related

ENSMUSP00000002976.4, ENSMUST00000002976.5

Conserved Domains (3) summary

pfam08357
Location:380 → 539

SEFIR; SEFIR domain

pfam16556
Location:48 → 198

IL17R_fnIII_D1; Interleukin-17 receptor, fibronectin-III-like domain 1

pfam16578
Location:199 → 303

IL17R_fnIII_D2; Interleukin 17 receptor D

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

120440143..120460692

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006505618.2 → XP_006505681.1 interleukin-17 receptor A isoform X1

See identical proteins and their annotated locations for XP_006505681.1

Conserved Domains (3) summary

pfam08357
Location:378 → 537

SEFIR; SEFIR domain

pfam16556
Location:48 → 198

IL17R_fnIII_D1; Interleukin-17 receptor, fibronectin-III-like domain 1

pfam16578
Location:199 → 303

IL17R_fnIII_D2; Interleukin 17 receptor D