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    Igk immunoglobulin kappa chain complex [ Mus musculus (house mouse) ]

    Gene ID: 243469, updated on 22-Oct-2024

    Summary

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    Official Symbol
    Igkprovided by MGI
    Official Full Name
    immunoglobulin kappa chain complexprovided by MGI
    Primary source
    MGI:MGI:96494
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    kappa
    Summary
    Summary:Immunoglobulins recognize foreign antigens and initiate immune responses such as phagocytosis and the complement system. Each immunoglobulin molecule consists of two identical heavy chains and two identical light chains. There are two classes of light chains, kappa and lambda. This region represents the germline organization of the kappa light chain locus from the C57BL/6J inbred mouse strain. The locus includes V (variable), J (joining), and C (constant) segments. During B cell development, a recombination event at the DNA level joins a single V segment with a J segment; the C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase, and by somatic hypermutation, which occurs during B cell maturation in the spleen and lymph nodes. Several V segments in this cluster are incapable of encoding a protein and are considered pseudogenes. [provided by RefSeq, Jul 2008]
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    Genomic context

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    See Igk in Genome Data Viewer
    Location:
    6 C1; 6 30.89 cM
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (67532620..70703738)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (67555636..70726754)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_16185 Neighboring gene STARR-seq mESC enhancer starr_16186 Neighboring gene myc induced nuclear antigen pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:67483136-67483367 Neighboring gene STARR-seq mESC enhancer starr_16187 Neighboring gene STARR-seq mESC enhancer starr_16188 Neighboring gene STARR-seq mESC enhancer starr_16189 Neighboring gene STARR-seq mESC enhancer starr_16190 Neighboring gene STARR-positive B cell enhancer mm9_chr6:67623335-67623635 Neighboring gene STARR-seq mESC enhancer starr_16191 Neighboring gene immunoglobulin kappa chain variable 2-137 Neighboring gene immunoglobulin kappa chain variable 14-134-1 Neighboring gene immunoglobulin kappa chain variable 1-136 Neighboring gene ribosomal protein L18A, pseudogene 2 Neighboring gene interleukin 23 receptor Neighboring gene immunoglobulin kappa variable 1-135 Neighboring gene tumor-associated calcium signal transducer 2 Neighboring gene STARR-seq mESC enhancer starr_16192 Neighboring gene immunoglobulin kappa chain variable 17-134 Neighboring gene ribosomal protein L18A, pseudogene 3 Neighboring gene immunoglobulin kappa variable 1-133 Neighboring gene immunoglobulin kappa chain variable 14-126-1 Neighboring gene immunoglobulin kappa variable 14-130 Neighboring gene STARR-seq mESC enhancer starr_16194 Neighboring gene immunoglobulin kappa variable 1-132 Neighboring gene immunoglobulin kappa variable 1-131 Neighboring gene tubulin, alpha 1A pseudogene Neighboring gene STARR-seq mESC enhancer starr_16196 Neighboring gene predicted gene, 38573 Neighboring gene immunoglobulin kappa variable 17-127 Neighboring gene immunoglobulin kappa variable 9-129 Neighboring gene immunoglobulin kappa chain variable 9-128 Neighboring gene immunoglobulin kappa variable 14-126 Neighboring gene immunoglobulin kappa variable 11-125 Neighboring gene tubulin, alpha 1A pseudogene Neighboring gene EGF-like repeats and discoidin I-like domains 3 pseudogene Neighboring gene predicted gene, 22425 Neighboring gene predicted gene, 24911 Neighboring gene immunoglobulin kappa chain variable 14-118-2 Neighboring gene immunoglobulin kappa chain variable 9-124 Neighboring gene immunoglobulin kappa chain variable 14-118-1 Neighboring gene immunoglobulin kappa variable 9-123 Neighboring gene immunoglobulin kappa variable 17-121 Neighboring gene predicted gene, 25910 Neighboring gene immunoglobulin kappa chain variable 1-122 Neighboring gene ARP2 actin-related protein 2 homolog pseudogene Neighboring gene immunoglobulin kappa chain variable 9-120 Neighboring gene immunoglobulin kappa chain variable 9-119 Neighboring gene immunoglobulin kappa chain variable 11-118 Neighboring gene immunoglobulin kappa variable 1-117 Neighboring gene immunoglobulin kappa chain variable Neighboring gene immunoglobulin kappa variable 2-116 Neighboring gene immunoglobulin kappa variable 1-115 Neighboring gene STARR-positive B cell enhancer mm9_chr6:68252207-68252508 Neighboring gene immunoglobulin kappa chain variable 2-113 Neighboring gene STARR-seq mESC enhancer starr_16198 Neighboring gene immunoglobulin kappa variable 14-111 Neighboring gene immunoglobulin kappa variable 2-112 Neighboring gene nucleosome assembly protein 1-like 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_16199 Neighboring gene STARR-seq mESC enhancer starr_16200 Neighboring gene immunoglobulin kappa variable 1-110 Neighboring gene immunoglobulin kappa variable 11-106 Neighboring gene immunoglobulin kappa variable 2-109 Neighboring gene immunoglobulin kappa variable 1-108 Neighboring gene immunoglobulin kappa variable 2-107 Neighboring gene immunoglobulin kappa chain variable 20-101-2 Neighboring gene immunoglobulin kappa chain variable 15-101-1 Neighboring gene immunoglobulin kappa chain variable 2-105 Neighboring gene predicted gene, 25436 Neighboring gene cortactin pseudogene Neighboring gene immunoglobulin kappa variable 16-104 Neighboring gene immunoglobulin kappa chain variable 15-103 Neighboring gene immunoglobulin kappa chain variable 15-102 Neighboring gene immunoglobulin kappa chain variable 15-101 Neighboring gene immunoglobulin kappa chain variable 14-100 Neighboring gene cortactin pseudogene Neighboring gene immunoglobulin kappa variable 12-98 Neighboring gene immunoglobulin kappa variable 1-99 Neighboring gene immunoglobulin kappa chain variable 15-97 Neighboring gene immunoglobulin kappa variable 2-95-2 Neighboring gene immunoglobulin kappa chain variable Neighboring gene predicted gene, 25833 Neighboring gene immunoglobulin kappa variable 10-96 Neighboring gene immunoglobulin kappa chain variable 2-93-1 Neighboring gene STARR-seq mESC enhancer starr_16202 Neighboring gene STARR-seq mESC enhancer starr_16201 Neighboring gene immunoglobulin kappa variable 10-95 Neighboring gene immunoglobulin kappa variable 10-94 Neighboring gene STARR-seq mESC enhancer starr_16204 Neighboring gene immunoglobulin kappa chain variable 13-89-1 Neighboring gene immunoglobulin kappa chain variable 19-93 Neighboring gene immunoglobulin kappa variable 4-92 Neighboring gene immunoglobulin kappa chain variable 4-91 Neighboring gene immunoglobulin kappa chain variable 12-89 Neighboring gene immunoglobulin kappa chain variable 4-90 Neighboring gene STARR-seq mESC enhancer starr_16205 Neighboring gene immunoglobulin kappa variable 13-87 Neighboring gene immunoglobulin kappa chain variable 1-88 Neighboring gene immunoglobulin kappa chain variable 13-80-1 Neighboring gene immunoglobulin kappa chain variable 13-85 Neighboring gene STARR-seq mESC enhancer starr_16206 Neighboring gene immunoglobulin kappa chain variable 13-84 Neighboring gene immunoglobulin kappa variable 4-86 Neighboring gene immunoglobulin kappa variable 13-78-1 Neighboring gene predicted gene, 53190 Neighboring gene immunoglobulin kappa chain variable 13-82 Neighboring gene immunoglobulin kappa chain variable 4-83 Neighboring gene STARR-seq mESC enhancer starr_16207 Neighboring gene immunoglobulin kappa variable 4-81 Neighboring gene immunoglobulin kappa variable 4-80 Neighboring gene immunoglobulin kappa chain variable 13-74-1 Neighboring gene immunoglobulin kappa chain variable 13-73-1 Neighboring gene immunoglobulin kappa variable 4-79 Neighboring gene immunoglobulin kappa variable 4-78 Neighboring gene immunoglobulin kappa chain variable 13-76 Neighboring gene immunoglobulin kappa chain variable 13-71-1 Neighboring gene STARR-seq mESC enhancer starr_16209 Neighboring gene immunoglobulin kappa variable 4-77 Neighboring gene immunoglobulin kappa chain variable 4-75 Neighboring gene STARR-seq mESC enhancer starr_16210 Neighboring gene immunoglobulin kappa variable 4-74 Neighboring gene immunoglobulin kappa variable 4-73 Neighboring gene STARR-seq mESC enhancer starr_16212 Neighboring gene STARR-seq mESC enhancer starr_16211 Neighboring gene immunoglobulin kappa chain variable 4-72 Neighboring gene immunoglobulin kappa chain variable 4-71 Neighboring gene immunoglobulin kappa chain variable 13-62-1 Neighboring gene immunoglobulin kappa chain variable 4-70 Neighboring gene immunoglobulin kappa chain variable 13-61-1 Neighboring gene immunoglobulin kappa chain variable 12-67 Neighboring gene immunoglobulin kappa variable 4-69 Neighboring gene immunoglobulin kappa chain variable 12-66 Neighboring gene STARR-seq mESC enhancer starr_16214 Neighboring gene immunoglobulin kappa variable 4-68 Neighboring gene immunoglobulin kappa chain variable 13-64 Neighboring gene immunoglobulin kappa chain variable 4-65 Neighboring gene immunoglobulin kappa variable 4-63 Neighboring gene immunoglobulin kappa variable 13-57-2 Neighboring gene immunoglobulin kappa variable 4-62 Neighboring gene immunoglobulin kappa chain variable 4-61 Neighboring gene immunoglobulin kappa chain variable 13-57-1 Neighboring gene immunoglobulin kappa chain variable 13-56-1 Neighboring gene immunoglobulin kappa variable 4-59 Neighboring gene immunoglobulin kappa variable 4-57-1 Neighboring gene immunoglobulin kappa chain variable 13-55-1 Neighboring gene immunoglobulin kappa variable 4-60 Neighboring gene ribonuclease P RNA-like 1 Neighboring gene immunoglobulin kappa chain variable 13-54-1 Neighboring gene immunoglobulin kappa variable 4-58 Neighboring gene immunoglobulin kappa variable 4-57 Neighboring gene immunoglobulin kappa chain variable 4-56 Neighboring gene immunoglobulin kappa variable 4-55 Neighboring gene immunoglobulin kappa chain variable 4-54 Neighboring gene immunoglobulin kappa variable 4-53 Neighboring gene immunoglobulin kappa chain variable 12-49 Neighboring gene immunoglobulin kappa chain variable 4-51 Neighboring gene STARR-seq mESC enhancer starr_16217 Neighboring gene immunoglobulin kappa variable 4-50 Neighboring gene immunoglobulin kappa variable 12-47 Neighboring gene immunoglobulin kappa variable 12-46 Neighboring gene immunoglobulin kappa variable 5-48 Neighboring gene STARR-seq mESC enhancer starr_16218 Neighboring gene STARR-seq mESC enhancer starr_16219 Neighboring gene STARR-seq mESC enhancer starr_16220 Neighboring gene immunoglobulin kappa variable 12-44 Neighboring gene immunoglobulin kappa chain variable 5-40-1 Neighboring gene immunoglobulin kappa chain variable 5-45 Neighboring gene immunoglobulin kappa chain variable 12-42 Neighboring gene immunoglobulin kappa chain variable 12-41 Neighboring gene immunoglobulin kappa chain variable 5-43 Neighboring gene STARR-seq mESC enhancer starr_16221 Neighboring gene immunoglobulin kappa chain variable 12-40 Neighboring gene STARR-positive B cell enhancer ABC_E6435 Neighboring gene STARR-seq mESC enhancer starr_16222 Neighboring gene immunoglobulin kappa variable 5-39 Neighboring gene immunoglobulin kappa chain variable 12-38 Neighboring gene STARR-seq mESC enhancer starr_16224 Neighboring gene STARR-seq mESC enhancer starr_16226 Neighboring gene STARR-seq mESC enhancer starr_16225 Neighboring gene immunoglobulin kappa chain variable 18-36 Neighboring gene STARR-seq mESC enhancer starr_16227 Neighboring gene STARR-seq mESC enhancer starr_16228 Neighboring gene immunoglobulin kappa variable 5-37 Neighboring gene STARR-seq mESC enhancer starr_16229 Neighboring gene STARR-seq mESC enhancer starr_16230 Neighboring gene immunoglobulin kappa variable 1-35 Neighboring gene immunoglobulin kappa variable 8-34 Neighboring gene immunoglobulin kappa chain variable 7-33 Neighboring gene immunoglobulin kappa variable 6-32 Neighboring gene immunoglobulin kappa chain variable 8-31 Neighboring gene immunoglobulin kappa chain variable 8-30 Neighboring gene STARR-seq mESC enhancer starr_16231 Neighboring gene immunoglobulin kappa chain variable 6-29 Neighboring gene immunoglobulin kappa variable 8-28 Neighboring gene immunoglobulin kappa variable 8-23-1 Neighboring gene immunoglobulin kappa chain variable 8-27 Neighboring gene S-adenosylmethionine decarboxylase, pseudogene 2 Neighboring gene immunoglobulin kappa variable 8-26 Neighboring gene STARR-seq mESC enhancer starr_16232 Neighboring gene immunoglobulin kappa chain variable 6-25 Neighboring gene immunoglobulin kappa chain variable 8-24 Neighboring gene immunoglobulin kappa variable 6-23 Neighboring gene predicted gene, 46962 Neighboring gene immunoglobulin kappa chain variable 8-22 Neighboring gene ornithine decarboxylase, structural 1 pseudogene Neighboring gene immunoglobulin kappa variable 8-21 Neighboring gene immunoglobulin kappa variable 6-20 Neighboring gene STARR-seq mESC enhancer starr_16234 Neighboring gene immunoglobulin kappa variable 8-19 Neighboring gene ornithine decarboxylase, structural 1 pseudogene Neighboring gene immunoglobulin kappa variable 8-18 Neighboring gene S-adenosylmethionine decarboxylase, pseudogene 5 Neighboring gene STARR-seq mESC enhancer starr_16235 Neighboring gene immunoglobulin kappa variable 6-17 Neighboring gene immunoglobulin kappa variable 8-16 Neighboring gene immunoglobulin kappa variable 6-15 Neighboring gene immunoglobulin kappa chain variable 3-12-1 Neighboring gene immunoglobulin kappa variable 6-14 Neighboring gene immunoglobulin kappa variable 6-13 Neighboring gene STARR-seq mESC enhancer starr_16236 Neighboring gene ornithine decarboxylase, structural 1 pseudogene Neighboring gene ornithine decarboxylase, structural 1 pseudogene Neighboring gene solute carrier family 5 (sodium-dependent vitamin transporter), member 6 pseudogene Neighboring gene immunoglobulin kappa variable 3-12 Neighboring gene STARR-positive B cell enhancer ABC_E6436 Neighboring gene STARR-seq mESC enhancer starr_16238 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:70712736-70712889 Neighboring gene STARR-positive B cell enhancer mm9_chr6:70702533-70702834 Neighboring gene STARR-positive B cell enhancer mm9_chr6:70694043-70694344 Neighboring gene STARR-positive B cell enhancer ABC_E2193 Neighboring gene STARR-positive B cell enhancer ABC_E11318 Neighboring gene STARR-positive B cell enhancer ABC_E11317 Neighboring gene STARR-positive B cell enhancer ABC_E9273 Neighboring gene ornithine decarboxylase, structural 1 pseudogene Neighboring gene ornithine decarboxylase, structural 1 pseudogene Neighboring gene immunoglobulin kappa variable 3-11 Neighboring gene immunoglobulin kappa variable 3-10 Neighboring gene immunoglobulin kappa variable 3-9 Neighboring gene immunoglobulin kappa variable 3-8 Neighboring gene immunoglobulin kappa variable 3-7 Neighboring gene immunoglobulin kappa variable 3-6 Neighboring gene immunoglobulin kappa chain variable 3-5 Neighboring gene immunoglobulin kappa variable 3-4 Neighboring gene immunoglobulin kappa variable 3-3 Neighboring gene immunoglobulin kappa variable 3-2 Neighboring gene immunoglobulin kappa variable 3-1 Neighboring gene predicted gene, 30211 Neighboring gene predicted gene, 57753 Neighboring gene predicted gene, 46961 Neighboring gene immunoglobulin kappa joining 4 Neighboring gene immunoglobulin kappa joining 5 Neighboring gene immunoglobulin kappa joining 3 Neighboring gene immunoglobulin kappa joining 2 Neighboring gene immunoglobulin kappa joining 1 Neighboring gene immunoglobulin kappa constant Neighboring gene ribose 5-phosphate isomerase A

    Genomic regions, transcripts, and products

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    Bibliography

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    Related articles in PubMed

    1. The kinetics of V-J joining throughout 3.5 megabases of the mouse Ig kappa locus fit a constrained diffusion model of nuclear organization. Li S, et al. FEBS Lett, 2003 Feb 11. PMID 12586350
    2. Subdomain structure of the matrix attachment region located within the mouse immunoglobulin kappa gene intron. Okada S, et al. Biochem Biophys Res Commun, 1996 May 15. PMID 8670229
    3. A targeted deletion of a region upstream from the Jkappa cluster impairs kappa chain rearrangement in cis in mice and in the 103/bcl2 cell line. Cocea L, et al. J Exp Med, 1999 May 3. PMID 10224284, Free PMC Article
    4. A plasma cell differentiation quality control ablates B cell clones with biallelic Ig rearrangements and truncated Ig production. Srour N, et al. J Exp Med, 2016 Jan 11. PMID 26666261, Free PMC Article
    5. Selection at multiple checkpoints focuses V(H)12 B cell differentiation toward a single B-1 cell specificity. Tatu C, et al. J Exp Med, 1999 Oct 4. PMID 10510080, Free PMC Article

    See all (223) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Hepatocyte-Derived Igkappa Exerts a Protective Effect against ConA-Induced Acute Liver Injury.
      Title: Hepatocyte-Derived Igκ Exerts a Protective Effect against ConA-Induced Acute Liver Injury.
    2. data suggest that Dnmt3a and Dnmt3b are critical to regulate the onset of Igkappa light chain rearrangement during early B-cell development
      Title: De novo DNA Methyltransferases Dnmt3a and Dnmt3b regulate the onset of Igκ light chain rearrangement during early B-cell development.
    3. ATM kinases activated by RAG DSBs during Igkappa recombination transduce transient H2AX/MDC1-independent signals that suppress initiation of further Igkappa rearrangements to control Igkappa allelic exclusion.
      Title: The ataxia telangiectasia mutated kinase controls Igκ allelic exclusion by inhibiting secondary Vκ-to-Jκ rearrangements.
    4. using mouse immunoglobulin-kappa (Igkappa) as a model system, we demonstrate that although individual haematopoietic stem cells are characterized by allelic plasticity, early lymphoid lineage cells become committed to the choice of a single allele, and this decision is then stably maintained in a clonal manner that predetermines monoallelic rearrangement in B cells
      Title: Clonal allelic predetermination of immunoglobulin-κ rearrangement.
    5. Igkappa rearrangements play an important role in receptor editing, a role that may explain why Igkappa recombination clearly fails to approach an equal rearrangement frequency for each variable (V) gene that might be considered optimal for diversity.
      Title: Skewed primary Igκ repertoire and V-J joining in C57BL/6 mice: implications for recombination accessibility and receptor editing.
    6. We conclude that the HS10, E3', and Ed differentially regulate Igkappa gene dynamics.
      Title: A new hypersensitive site, HS10, and the enhancers, E3' and Ed, differentially regulate Igκ gene expression.
    7. Sis(-/-) mice exhibit a skewed Igkappa repertoire with markedly decreased distal and enhanced proximal Vkappa gene usage for primary rearrangement
      Title: A multifunctional element in the mouse Igκ locus that specifies repertoire and Ig loci subnuclear location.
    8. The Igkappa gene enhancers, E3' and Ed, are essential for triggering transcription.
      Title: The Igκ gene enhancers, E3' and Ed, are essential for triggering transcription.
    9. Non-allergen-mediated hypersensitivity responses in the colon and ileum are associated with increases in Ig kappa chain production in a murine model of mast cell-dependent colitis.
      Title: Ig-free light chains play a crucial role in murine mast cell-dependent colitis and are associated with human inflammatory bowel diseases.
    10. Splicing inhibition, nonsense-mediated decay and nonsense-altered splicing each has an individual partial effect that together associate into an efficient surveillance machinery, downregulating nonfunctional immunoglobulin kappa mRNA.
      Title: Multiple RNA surveillance mechanisms cooperate to reduce the amount of nonfunctional Ig kappa transcripts.
    Submit: New GeneRIF Correction See all GeneRIFs (23)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Other Names

    • kappa light chain variable region

    Clone Names

    • MGC6612, MGC28604, MGC41421, MGC102615, MGC150007

    General protein information

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    Names
    immunoglobulin kappa chain complex
    kappa light chain variable region

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_005612.1 

      Range
      656..3171774
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      67532620..70703738
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001013763.1: Suppressed sequence

      Description
      NM_001013763.1: This RefSeq record was removed by NCBI staff. Contact [email protected] for further information.
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.