Cdh3 cadherin 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cdh3provided by MGI
Official Full Name: cadherin 3provided by MGI
Primary source: MGI:MGI:88356
See related: Ensembl:ENSMUSG00000061048 AllianceGenome:MGI:88356
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Cadp; Cdhp; Pcad; P-cadherin
Summary: This gene encodes a calcium-dependent cell-cell adhesion protein containing five cadherin domains. The encoded protein plays a role in epithelial outgrowth, such as that which occurs during the development of hair follicles and limb buds. Loss of function of the related gene in humans results in ectodermal dysplasia, ectrodactyly, and macular dystrophy and congential hypotrichosis with juvenile macular dystrophy. This gene is located in the vicinity of similar cadherin genes on chromosome 8. The proprotein is further cleaved into a functional chain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]
Expression: Biased expression in placenta adult (RPKM 46.1), limb E14.5 (RPKM 21.0) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 D3; 8 53.16 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (107237484..107283543)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (106510852..106556911)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The transcription factors Junb and Fosl2 cooperate to regulate Cdh3 expression in 15P-1 Sertoli cells.
Title: The transcription factors Junb and Fosl2 cooperate to regulate Cdh3 expression in 15P-1 Sertoli cells.
P-Cadherin is not required for maintenance of retinal stem cells in vivo.
Title: P-Cadherin is necessary for retinal stem cell behavior in vitro, but not in vivo.
P-cadherin (CDH3) is highly dominant in both mouse and human retinal pigment epithelium in situ. The degree of dominance of P-cadherin is surprisingly large, with mouse Cdh3 and human CDH3 accounting for 82-85% and 92-93% of the total of the three cadherin mRNAs, respectively.
Title: Cadherins in the retinal pigment epithelium (RPE) revisited: P-cadherin is the highly dominant cadherin expressed in human and mouse RPE in vivo.
role of P-cadherin through beta-PIX-mediated Cdc42 activation in the regulation of cell polarity
Title: P-cadherin promotes collective cell migration via a Cdc42-mediated increase in mechanical forces.
P-cadherin is a direct PAX3-FOXO1A transcriptional target involved in Alveolar rhabdomyosarcoma aggressiveness.
Title: P-cadherin is a direct PAX3-FOXO1A target involved in alveolar rhabdomyosarcoma aggressiveness.
importance of cadherin-based cell-cell adhesions in coordinating mechanical activity of epithelial cells
Title: Cadherin-based intercellular adhesions organize epithelial cell-matrix traction forces.
Loss of P-cadherin is associated with melanoma.
Title: P-cadherin expression reduces melanoma growth, invasion, and responsiveness to growth factors in nude mice.
UVB exposure resulted in the overexpression of the cytokines, tumour necrosis factor (TNF)-alpha, interleukin (IL)-6 and the adhesion molecule P-cadherin.
Title: Topical isoflavonoids reduce experimental cutaneous inflammation in mice.
P-cadherin is a newly defined transcriptional target gene of p63, with a crucial role in hair follicle morphogenesis as well as the apical ectodermal ridge during limb bud outgrowth in humans whereas it is not required for either in mice.
Title: P-cadherin is a p63 target gene with a crucial role in the developing human limb bud and hair follicle.
Truncated P-cadherin promotes melanoma cell invasion and migration and therefore has an important role in the progression of malignant melanoma.
Title: Functional implication of truncated P-cadherin expression in malignant melanoma.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (1) 1 citation

General gene information

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Markers

AI385538 (e-PCR)
- UniSTS:179808

Cdh3 (e-PCR), detects polymorphism
- UniSTS:265060

Cdh3 (e-PCR), detects polymorphism
- UniSTS:545910

X06340 (e-PCR)
- UniSTS:186287

NoName (e-PCR)
- UniSTS:548531

Cdh3 (e-PCR), detects polymorphism
- UniSTS:548055

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables beta-catenin binding	IBA Inferred from Biological aspect of Ancestor more info
enables cadherin binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in adherens junction organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell-cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell-cell adhesion mediated by cadherin	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell junction assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in hair cycle process	IEA Inferred from Electronic Annotation more info
involved_in hair cycle process	ISO Inferred from Sequence Orthology more info
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	IEA Inferred from Electronic Annotation more info
involved_in keratinization	IEA Inferred from Electronic Annotation more info
involved_in keratinization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of timing of catagen	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of timing of catagen	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transforming growth factor beta receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within_negative_effect negative regulation of transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of insulin-like growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_positive_effect positive regulation of insulin-like growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of keratinocyte proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of keratinocyte proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of melanin biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of melanin biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of melanosome transport	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of melanosome transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of tyrosinase activity	ISO Inferred from Sequence Orthology more info
involved_in response to xenobiotic stimulus	IEA Inferred from Electronic Annotation more info
involved_in retina homeostasis	IEA Inferred from Electronic Annotation more info
involved_in retina homeostasis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in adherens junction	IBA Inferred from Biological aspect of Ancestor more info
located_in adherens junction	IDA Inferred from Direct Assay more info	PubMed
part_of catenin complex	IBA Inferred from Biological aspect of Ancestor more info
located_in cell junction	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cadherin-3

Names: RPE-specific cadherin; placental cadherin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001037809.5 → NP_001032898.1 cadherin-3 isoform a preproprotein

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).

Source sequence(s)

AC132132, AC164096, AK045041, BC098459

Consensus CDS

CCDS22637.1

UniProtKB/Swiss-Prot

P10287, Q61465, Q8BSL6

UniProtKB/TrEMBL

Q80VY6

Related

ENSMUSP00000079613.7, ENSMUST00000080797.8

Conserved Domains (4) summary

cd11304
Location:211 → 316

Cadherin_repeat; Cadherin tandem repeat domain

pfam01049
Location:672 → 819

Cadherin_C; Cadherin cytoplasmic region

cl09101
Location:536 → 630

E_set; Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus

cl28881
Location:103 → 203

CA_like; Cadherin repeat-like domain
NM_007665.3 → NP_031691.1 cadherin-3 isoform b preproprotein

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (b) is shorter than isoform a.

Source sequence(s)

AC132132, AC164096, AK045041

UniProtKB/TrEMBL

Q80VY6, Q8BRE1

Conserved Domains (3) summary

cd11304
Location:210 → 315

Cadherin_repeat; Cadherin tandem repeat domain

pfam01049
Location:679 → 816

Cadherin_C; Cadherin cytoplasmic region

cl09101
Location:102 → 202

E_set; Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus