Olfm2 olfactomedin 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Olfm2provided by MGI
Official Full Name: olfactomedin 2provided by MGI
Primary source: MGI:MGI:3045350
See related: Ensembl:ENSMUSG00000032172 AllianceGenome:MGI:3045350
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: A030009A06Rik
Summary: Involved in neurotransmitter receptor localization to postsynaptic specialization membrane. Acts upstream of or within locomotory behavior and visual perception. Located in synaptic membrane. Part of AMPA glutamate receptor complex. Is active in glutamatergic synapse. Is extrinsic component of postsynaptic density membrane. Is expressed in several structures, including central nervous system; eye; and orbito-sphenoid. Orthologous to human OLFM2 (olfactomedin 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in CNS E18 (RPKM 44.2), cortex adult (RPKM 37.9) and 9 other tissues See more
Orthologs: human all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 9 A3; 9 7.6 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (20578986..20657660, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (20667690..20746333, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results suggest that heterodimers of Olfm1 and Olfm2 interact with AMPAR more efficiently than Olfm2 homodimers and that Olfm2 plays a role in the organization of the AMPA receptor complexes.
Title: Deletion of olfactomedin 2 induces changes in the AMPA receptor complex and impairs visual, olfactory, and motor functions in mice.
Highly conserved OLFM2 protein may play an important role in the course of retinal and eye development.
Title: Olfactomedin 2: expression in the eye and interaction with other olfactomedin domain-containing proteins.

Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (2) 1 citation

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

NoName (e-PCR)
- UniSTS:493348

Olfm2 (e-PCR), detects polymorphism
- UniSTS:534579

Olfm2 (e-PCR), detects polymorphism
- UniSTS:534580

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neurotransmitter receptor localization to postsynaptic specialization membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in neurotransmitter receptor localization to postsynaptic specialization membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of smooth muscle cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of smooth muscle cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within protein secretion	ISO Inferred from Sequence Orthology more info
involved_in regulation of vascular associated smooth muscle cell dedifferentiation	ISO Inferred from Sequence Orthology more info
involved_in regulation of vascular associated smooth muscle cell dedifferentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within visual perception	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of AMPA glutamate receptor complex	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in extracellular region	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
is_active_in extrinsic component of postsynaptic density membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in extrinsic component of postsynaptic density membrane	IEP Inferred from Expression Pattern more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IEP Inferred from Expression Pattern more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in synaptic membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: noelin-2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001357635.1 → NP_001344564.1 noelin-2 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AC164565, AC166365

Consensus CDS

CCDS90507.1

UniProtKB/TrEMBL

A0A1L1SV46

Related

ENSMUSP00000151018.2, ENSMUST00000217198.2

Conserved Domains (2) summary

pfam02191
Location:222 → 466

OLF; Olfactomedin-like domain

pfam12308
Location:49 → 144

Noelin-1; Neurogenesis glycoprotein
NM_001357639.1 → NP_001344568.1 noelin-2 isoform 2 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.

Source sequence(s)

AC164565, AC166365

Consensus CDS

CCDS90508.1

UniProtKB/TrEMBL

A0A1L1SQX6

Related

ENSMUSP00000149231.2, ENSMUST00000215999.2

Conserved Domains (2) summary

pfam02191
Location:200 → 444

OLF; Olfactomedin-like domain

pfam12308
Location:27 → 122

Noelin-1; Neurogenesis glycoprotein
NM_173777.4 → NP_776138.2 noelin-2 isoform 3 precursor

See identical proteins and their annotated locations for NP_776138.2

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus compared to isoform 1.

Source sequence(s)

AC164565, AK037199, BE948965

Consensus CDS

CCDS40546.1

UniProtKB/Swiss-Prot

Q0VFZ0, Q0VG58, Q8BM13

Related

ENSMUSP00000034692.8, ENSMUST00000034692.9

Conserved Domains (2) summary

pfam02191
Location:192 → 436

OLF; Olfactomedin-like domain

pfam12308
Location:19 → 114

Noelin-1; Neurogenesis glycoprotein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

20578986..20657660 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030244363.2 → XP_030100223.1 noelin-2 isoform X1

Conserved Domains (2) summary

pfam02191
Location:187 → 431

OLF; Olfactomedin-like domain

pfam12308
Location:14 → 109

Noelin-1; Neurogenesis glycoprotein
XM_030244364.2 → XP_030100224.1 noelin-2 isoform X1

Conserved Domains (2) summary

pfam02191
Location:187 → 431

OLF; Olfactomedin-like domain

pfam12308
Location:14 → 109

Noelin-1; Neurogenesis glycoprotein
XM_030244365.2 → XP_030100225.1 noelin-2 isoform X2

Conserved Domains (2) summary

pfam02191
Location:120 → 364

OLF; Olfactomedin-like domain

pfam12308
Location:1 → 42

Noelin-1; Neurogenesis glycoprotein