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    Ces1e carboxylesterase 1E [ Mus musculus (house mouse) ]

    Gene ID: 13897, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Ces1eprovided by MGI
    Official Full Name
    carboxylesterase 1Eprovided by MGI
    Primary source
    MGI:MGI:95432
    See related
    Ensembl:ENSMUSG00000061959 AllianceGenome:MGI:95432
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Eg; Es22; Es-22; egasyn
    Summary
    Enables carboxylesterase activity. Predicted to be involved in several processes, including cellular response to cholesterol; cholesterol homeostasis; and regulation of steroid metabolic process. Predicted to be located in cytoplasm and intracellular membrane-bounded organelle. Predicted to be active in endoplasmic reticulum and lipid droplet. Is expressed in several structures, including alimentary system; hemolymphoid system; liver; nose; and respiratory system. Human ortholog(s) of this gene implicated in colorectal cancer and gastrointestinal system cancer. Orthologous to human CES1 (carboxylesterase 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in liver adult (RPKM 36.8), kidney adult (RPKM 21.8) and 3 other tissues See more
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    Genomic context

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    See Ces1e in Genome Data Viewer
    Location:
    8 C5; 8 45.11 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (93927846..93956233, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (93201218..93229631, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene 45910 Neighboring gene STARR-seq mESC enhancer starr_22332 Neighboring gene carboxylesterase 1D Neighboring gene carboxylesterase 1F Neighboring gene carboxylesterase 1G

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification and androgen regulation of egasyn in the mouse epididymis. Abou-Haila A, et al. Biochim Biophys Acta, 1998 Feb 4. PMID 9531973
    2. Isolation, characterization, and radioimmunoassay of murine egasyn, a protein stabilizing glucuronidase membrane binding. Lusis AJ, et al. J Biol Chem, 1976 Dec 25. PMID 826534
    3. Inheritance in mice of the membrane anchor protein egasyn: the Eg locus determines egasyn levels. Lusis AJ, et al. Biochem Genet, 1977 Feb. PMID 849245
    4. Relationships between levels of membrane-bound glucuronidase and the associated protein egasyn in mouse tissues. Lusis AJ, et al. J Cell Biol, 1977 Jun. PMID 873997, Free PMC Article
    5. Separate genes determining the structure and intracellular location of hepatic glucuronidase. Ganschow R, et al. Proc Natl Acad Sci U S A, 1967 Sep. PMID 5233850, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Natural deletion of mouse carboxylesterases Ces1c/d/e impacts drug metabolism and metabolic syndrome development.
      Title: Natural deletion of mouse carboxylesterases Ces1c/d/e impacts drug metabolism and metabolic syndrome development.
    2. the carboxylesterase 1d (Ces1d) and carboxylesterase 1e (Ces1e) expression and the capacity of hydrolytic activity of liver and intestine decreased, whereas the Akt/mTOR/HIF-1alpha/ Stra13 (DEC1) signaling was activated in type 2 diabetes mice.
      Title: Decreased carboxylesterases expression and hydrolytic activity in type 2 diabetic mice through Akt/mTOR/HIF-1α/Stra13 pathway.
    3. The Es22 plays a role in liver retinoid metabolism.
      Title: Esterase 22 and beta-glucuronidase hydrolyze retinoids in mouse liver.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Spontaneous (1)  1 citation

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables carboxylesterase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables carboxylesterase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables carboxylic ester hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables retinyl-palmitate esterase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sterol ester esterase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to cholesterol ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to low-density lipoprotein particle stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cholesterol biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cholesterol homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cholesterol metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in epithelial cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lipid catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in medium-chain fatty acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cholesterol storage ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cholesterol efflux ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cholesterol metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of bile acid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of bile acid secretion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in retinol metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in reverse cholesterol transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum lumen IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in lipid droplet IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lipid droplet ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    carboxylesterase 1E
    Names
    esterase-22
    liver carboxylesterase 22
    NP_001390662.1
    NP_598421.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001403733.1 → NP_001390662.1  carboxylesterase 1E isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC162949
      UniProtKB/TrEMBL
      H3BL34
      Related
      ENSMUSP00000135636.2, ENSMUST00000176282.2

    2. NM_133660.4 → NP_598421.1  carboxylesterase 1E isoform 1 precursor

      See identical proteins and their annotated locations for NP_598421.1

      Status: VALIDATED

      Source sequence(s)
      AC162949
      Consensus CDS
      CCDS22529.1
      UniProtKB/Swiss-Prot
      Q64176
      UniProtKB/TrEMBL
      Q3UN14
      Related
      ENSMUSP00000034173.8, ENSMUST00000034173.14
      Conserved Domains (2) summary
      COG0657
      Location:44 → 242
      Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
      pfam00135
      Location:25 → 546
      COesterase; Carboxylesterase family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      93927846..93956233 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q64176.1 GenPept UniProtKB/Swiss-Prot:Q64176

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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