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    Spinkl serine protease inhibitor, Kazal type-like [ Mus musculus (house mouse) ]

    Gene ID: 77424, updated on 9-Dec-2024

    Summary

    Official Symbol
    Spinklprovided by MGI
    Official Full Name
    serine protease inhibitor, Kazal type-likeprovided by MGI
    Primary source
    MGI:MGI:1924674
    See related
    Ensembl:ENSMUSG00000053729 AllianceGenome:MGI:1924674
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    9530002K18Rik
    Summary
    Acts upstream of or within negative regulation of sperm capacitation and positive regulation of flagellated sperm motility. Located in extracellular space. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

    See Spinkl in Genome Data Viewer
    Location:
    18 B3; 18 23.74 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (44299425..44309774, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (44166358..44176707, complement)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene MARCO like Neighboring gene STARR-seq mESC enhancer starr_44456 Neighboring gene predicted gene 10267 Neighboring gene serine peptidase inhibitor, Kazal type 11 Neighboring gene predicted gene, 41716 Neighboring gene neuropeptide Y receptor Y6

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    General protein information

    Preferred Names
    serine protease inhibitor kazal-like protein, minor form
    Names
    SPINKL, minor form

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_183123.2NP_898946.1  serine protease inhibitor kazal-like protein, minor form precursor

      See identical proteins and their annotated locations for NP_898946.1

      Status: VALIDATED

      Source sequence(s)
      AK020535
      Consensus CDS
      CCDS50273.1
      UniProtKB/Swiss-Prot
      Q8CEK3
      Related
      ENSMUSP00000063376.4, ENSMUST00000066328.5
      Conserved Domains (1) summary
      cd00104
      Location:4874
      KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      44299425..44309774 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006526352.4XP_006526415.1  serine protease inhibitor kazal-like protein, minor form isoform X1

      See identical proteins and their annotated locations for XP_006526415.1

      UniProtKB/Swiss-Prot
      Q8CEK3
      Conserved Domains (1) summary
      cd00104
      Location:4874
      KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...