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    Il24 interleukin 24 [ Mus musculus (house mouse) ]

    Gene ID: 93672, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Il24provided by MGI
    Official Full Name
    interleukin 24provided by MGI
    Primary source
    MGI:MGI:2135548
    See related
    Ensembl:ENSMUSG00000026420 AllianceGenome:MGI:2135548
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    FISP; If2e; Mda7; St16; Mda-7
    Summary
    Predicted to enable cytokine activity. Acts upstream of or within positive regulation of apoptotic process and positive regulation of cysteine-type endopeptidase activity involved in apoptotic process. Located in extracellular space. Is expressed in alimentary system; brain; gonad; hemolymphoid system gland; and metanephros. Orthologous to human IL24 (interleukin 24). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    human all
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    Genomic context

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    See Il24 in Genome Data Viewer
    Location:
    1 E4; 1 56.89 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (130809801..130815153, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (130882074..130887411, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene polymeric immunoglobulin receptor Neighboring gene STARR-positive B cell enhancer ABC_E9184 Neighboring gene STARR-positive B cell enhancer ABC_E9478 Neighboring gene Fc fragment of IgM receptor Neighboring gene STARR-seq mESC enhancer starr_02206 Neighboring gene interleukin 20 Neighboring gene interleukin 19

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. IL-24 is the key effector of Th9 cell-mediated tumor immunotherapy. Chen J, et al. iScience, 2023 Sep 15. PMID 37680459, Free PMC Article
    2. Interleukin 24 promotes cell death in renal epithelial cells and is associated with acute renal injury. Schütte-Nütgen K, et al. Am J Transplant, 2022 Nov. PMID 35801504
    3. Apogossypol derivative BI-97C1 (Sabutoclax) targeting Mcl-1 sensitizes prostate cancer cells to mda-7/IL-24-mediated toxicity. Dash R, et al. Proc Natl Acad Sci U S A, 2011 May 24. PMID 21555592, Free PMC Article
    4. Interleukin-24 protects against liver injury in mouse models. Wang HH, et al. EBioMedicine, 2021 Feb. PMID 33508745, Free PMC Article
    5. Interleukin-24 suppresses the growth of vascular smooth muscle cells by inhibiting H(2)O(2)-induced reactive oxygen species production. Lee KM, et al. Pharmacology, 2012. PMID 23052189

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Spinal interleukin-24 contributes to neuropathic pain after peripheral nerve injury through interleukin-20 receptor2 in mice.
      Title: Spinal interleukin-24 contributes to neuropathic pain after peripheral nerve injury through interleukin-20 receptor2 in mice.
    2. A tissue injury sensing and repair pathway distinct from host pathogen defense.
      Title: A tissue injury sensing and repair pathway distinct from host pathogen defense.
    3. Interleukin 24 promotes cell death in renal epithelial cells and is associated with acute renal injury.
      Title: Interleukin 24 promotes cell death in renal epithelial cells and is associated with acute renal injury.
    4. Methyltransferase-like 3 leads to lung injury by up-regulation of interleukin 24 through N6-methyladenosine-dependent mRNA stability and translation efficiency in mice exposed to fine particulate matter 2.5.
      Title: Methyltransferase-like 3 leads to lung injury by up-regulation of interleukin 24 through N6-methyladenosine-dependent mRNA stability and translation efficiency in mice exposed to fine particulate matter 2.5.
    5. IL-24 intrinsically regulates Th17 cell pathogenicity in mice.
      Title: IL-24 intrinsically regulates Th17 cell pathogenicity in mice.
    6. Protein kinase R is an innate immune sensor of proteotoxic stress via accumulation of cytoplasmic IL-24.
      Title: Protein kinase R is an innate immune sensor of proteotoxic stress via accumulation of cytoplasmic IL-24.
    7. IL-24 deficiency protects mice against bleomycin-induced pulmonary fibrosis by repressing IL-4-induced M2 program in macrophages.
      Title: IL-24 deficiency protects mice against bleomycin-induced pulmonary fibrosis by repressing IL-4-induced M2 program in macrophages.
    8. Interleukin-24 protects against liver injury in mouse models.
      Title: Interleukin-24 protects against liver injury in mouse models.
    9. Interleukin-24 regulates mucosal remodeling in inflammatory bowel diseases.
      Title: Interleukin-24 regulates mucosal remodeling in inflammatory bowel diseases.
    10. The Cytokine IL-17A Limits Th17 Pathogenicity via a Negative Feedback Loop Driven by Autocrine Induction of IL-24.
      Title: The Cytokine IL-17A Limits Th17 Pathogenicity via a Negative Feedback Loop Driven by Autocrine Induction of IL-24.
    Submit: New GeneRIF Correction See all GeneRIFs (27)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (3)  1 citation

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cytokine activity ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of cysteine-type endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of tyrosine phosphorylation of STAT protein ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    interleukin-24
    Names
    IL-24
    IL-4-induced secreted protein
    interferon 2e
    melanoma differentiation-associated gene 7 protein
    th2-specific cytokine FISP

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053095.3 → NP_444325.3  interleukin-24 precursor

      Status: VALIDATED

      Source sequence(s)
      AC165322
      Consensus CDS
      CCDS15262.2
      UniProtKB/Swiss-Prot
      Q925J3, Q925S4
      UniProtKB/TrEMBL
      A0A087WQD7, A0A0R4J1N5
      Related
      ENSMUSP00000113064.3, ENSMUST00000121040.8
      Conserved Domains (1) summary
      cl02501
      Location:33 → 175
      IL10; Interleukin 10

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      130809801..130815153 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q925S4.1 GenPept UniProtKB/Swiss-Prot:Q925S4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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