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    Krt86 keratin 86 [ Mus musculus (house mouse) ]

    Gene ID: 16679, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Krt86provided by MGI
    Official Full Name
    keratin 86provided by MGI
    Primary source
    MGI:MGI:109362
    See related
    Ensembl:ENSMUSG00000067614 AllianceGenome:MGI:109362
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Khb4; MHb4; Krt2-10; Krt2-11; 5430421N21Rik
    Summary
    Predicted to be a structural constituent of skin epidermis. Predicted to be involved in intermediate filament organization and keratinization. Predicted to be active in keratin filament. Is expressed in digit epidermis and hair shaft. Human ortholog(s) of this gene implicated in hair disease and monilethrix. Orthologous to human KRT86 (keratin 86). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

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    See Krt86 in Genome Data Viewer
    Location:
    15 F2; 15 56.9 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (101371359..101377864)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (101473478..101479983)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene keratin 88 Neighboring gene keratin 81 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:101316581-101316768 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:101316810-101316963 Neighboring gene keratin 83 Neighboring gene STARR-seq mESC enhancer starr_39797 Neighboring gene type II keratin Kb32P

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Structure and site of expression of a murine type II hair keratin. Tobiasch E, et al. Mol Biol Rep, 1992 Feb. PMID 1372089
    2. Transient expression of mouse hair keratins in transfected HeLa cells: interactions between "hard" and "soft" keratins. Yu DW, et al. J Invest Dermatol, 1991 Aug. PMID 1712823
    3. Alternative splicing of amelogenins. Simmer JP. Connect Tissue Res, 1995. PMID 7554909
    4. Nonepidermal members of the keratin multigene family: cDNA sequences and in situ localization of the mRNAs. Knapp B, et al. Nucleic Acids Res, 1986 Jan 24. PMID 2418416, Free PMC Article
    5. Sequences and differential expression of three novel human type-II hair keratins. Rogers MA, et al. Differentiation, 1997 Feb. PMID 9084137

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables structural constituent of skin epidermis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in intermediate filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in keratinization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in keratin filament IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in keratin filament ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    keratin, type II cuticular Hb6
    Names
    K86
    keratin complex 2, basic, gene 10
    type II hair keratin Hb6
    type-II keratin Kb26

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010667.2 → NP_034797.1  keratin, type II cuticular Hb6

      See identical proteins and their annotated locations for NP_034797.1

      Status: PROVISIONAL

      Source sequence(s)
      AK161149
      Consensus CDS
      CCDS37218.1
      UniProtKB/Swiss-Prot
      P97861, Q3TTV9
      UniProtKB/TrEMBL
      B2RTB6, Q61726
      Related
      ENSMUSP00000085365.4, ENSMUST00000088049.5
      Conserved Domains (3) summary
      pfam00038
      Location:105 → 416
      Filament; Intermediate filament protein
      pfam16208
      Location:4 → 102
      Keratin_2_head; Keratin type II head
      cl23720
      Location:315 → 383
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      101371359..101377864
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P97861.2 GenPept UniProtKB/Swiss-Prot:P97861

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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