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    Decr2 2-4-dienoyl-Coenzyme A reductase 2, peroxisomal [ Mus musculus (house mouse) ]

    Gene ID: 26378, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Decr2provided by MGI
    Official Full Name
    2-4-dienoyl-Coenzyme A reductase 2, peroxisomalprovided by MGI
    Primary source
    MGI:MGI:1347059
    See related
    Ensembl:ENSMUSG00000036775 AllianceGenome:MGI:1347059
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable 2,4-dienoyl-CoA reductase (NADPH) activity and trans-2-enoyl-CoA reductase (NADPH) activity. Predicted to be involved in unsaturated fatty acid biosynthetic process. Predicted to be located in peroxisomal membrane. Predicted to be active in peroxisome. Orthologous to human DECR2 (2,4-dienoyl-CoA reductase 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in liver adult (RPKM 56.4), bladder adult (RPKM 32.6) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Decr2 in Genome Data Viewer
    Location:
    17 A3.3; 17 13.06 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (26300182..26309096, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (26081208..26090322, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700022N22 gene Neighboring gene RAB11 family interacting protein 3 (class II) Neighboring gene STARR-positive B cell enhancer ABC_E1937 Neighboring gene STARR-seq mESC enhancer starr_42116 Neighboring gene membrane-associated ring finger (C3HC4) 5 pseudogene Neighboring gene NME/NM23 nucleoside diphosphate kinase 4 Neighboring gene small nuclear ribonucleoprotein polypeptide G pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The mouse gene PDCR encodes a peroxisomal delta(2), delta(4)-dienoyl-CoA reductase. Geisbrecht BV, et al. J Biol Chem, 1999 Sep 3. PMID 10464321
    2. Characterisation of human peroxisomal 2,4-dienoyl-CoA reductase. De Nys K, et al. Biochim Biophys Acta, 2001 Aug 29. PMID 11514237
    3. TRIB3 promotes pulmonary fibrosis through inhibiting SLUG degradation by physically interacting with MDM2. Lv X, et al. Acta Pharm Sin B, 2023 Apr. PMID 37139431, Free PMC Article
    4. Searching QTL by gene expression: analysis of diabesity. Brown AC, et al. BMC Genet, 2005 Mar 10. PMID 15760467, Free PMC Article
    5. Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant. Quinlan MA, et al. Front Mol Neurosci, 2020. PMID 32581705, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 2,4-dienoyl-CoA reductase (NADPH) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 2,4-dienoyl-CoA reductase (NADPH) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables 2,4-dienoyl-CoA reductase (NADPH) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables trans-2-enoyl-CoA reductase (NADPH) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in fatty acid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fatty acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in unsaturated fatty acid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in unsaturated fatty acid biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in peroxisomal membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in peroxisome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in peroxisome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in peroxisome ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    peroxisomal 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing]
    Names
    2,4-dienoyl-CoA reductase 2
    peroxisomal 2,4-dienoyl-CoA reductase
    NP_001398237.1
    NP_001398238.1
    NP_001398239.1
    NP_001398240.1
    NP_001398241.1
    NP_001398242.1
    NP_001398243.1
    NP_001398244.1
    NP_001398245.1
    NP_001398246.1
    NP_001398247.1
    NP_036063.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001411308.1 → NP_001398237.1  peroxisomal 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing] isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC140047
      UniProtKB/TrEMBL
      A0A494B909
      Related
      ENSMUSP00000157435.2, ENSMUST00000237265.2

    2. NM_001411309.1 → NP_001398238.1  peroxisomal 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing] isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC140047

    3. NM_001411310.1 → NP_001398239.1  peroxisomal 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing] isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC140047
      UniProtKB/Swiss-Prot
      Q9WV68
      UniProtKB/TrEMBL
      Q3UVJ7

    4. NM_001411311.1 → NP_001398240.1  peroxisomal 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing] isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC140047
      UniProtKB/Swiss-Prot
      Q9WV68
      UniProtKB/TrEMBL
      Q3UVJ7

    5. NM_001411312.1 → NP_001398241.1  peroxisomal 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing] isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC140047

    6. NM_001411313.1 → NP_001398242.1  peroxisomal 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing] isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC140047
      Related
      ENSMUST00000235318.2

    7. NM_001411314.1 → NP_001398243.1  peroxisomal 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing] isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC140047
      UniProtKB/TrEMBL
      A0A494BB28
      Related
      ENSMUSP00000158287.2, ENSMUST00000236268.2

    8. NM_001411315.1 → NP_001398244.1  peroxisomal 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing] isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC140047

    9. NM_001411316.1 → NP_001398245.1  peroxisomal 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing] isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC140047
      Related
      ENSMUSP00000158163.2, ENSMUST00000150534.9

    10. NM_001411317.1 → NP_001398246.1  peroxisomal 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing] isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC140047
      Related
      ENSMUSP00000157417.2, ENSMUST00000237875.2

    11. NM_001411318.1 → NP_001398247.1  peroxisomal 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing] isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC140047

    12. NM_011933.3 → NP_036063.1  peroxisomal 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing] isoform 1

      See identical proteins and their annotated locations for NP_036063.1

      Status: VALIDATED

      Source sequence(s)
      AC140047
      Consensus CDS
      CCDS28543.1
      UniProtKB/Swiss-Prot
      Q9WV68
      UniProtKB/TrEMBL
      Q3TR93, Q3UEY0, Q3UVJ7
      Related
      ENSMUSP00000045621.7, ENSMUST00000040907.8
      Conserved Domains (2) summary
      cd05369
      Location:26 → 273
      TER_DECR_SDR_a; Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR
      PRK07576
      Location:26 → 271
      PRK07576; short chain dehydrogenase; Provisional

    RNA

    1. NR_177215.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC140047
      Related
      ENSMUST00000137672.3

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      26300182..26309096 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9WV68.1 GenPept UniProtKB/Swiss-Prot:Q9WV68

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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