Tff2 trefoil factor 2 (spasmolytic protein 1) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tff2provided by MGI
Official Full Name: trefoil factor 2 (spasmolytic protein 1)provided by MGI
Primary source: MGI:MGI:1306805
See related: Ensembl:ENSMUSG00000024028 AllianceGenome:MGI:1306805
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: SP; mSP
Summary: Enables CXCR4 chemokine receptor binding activity. Acts upstream of or within several processes, including negative regulation of gastric acid secretion; negative regulation of macrophage activation; and positive regulation of ERK1 and ERK2 cascade. Located in extracellular space. Is expressed in several structures, including alimentary system; genitourinary system; liver; skeleton; and thymus. Orthologous to human TFF2 (trefoil factor 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in duodenum adult (RPKM 2097.9), stomach adult (RPKM 1770.2) and 1 other tissue See more
Orthologs: human all
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Genomic context

Location:: 17 A3.3; 17 15.8 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (31360036..31363256, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (31141062..31144282, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Trefoil Factor 2 Expressed by the Murine Pancreatic Acinar Cells Is Required for the Development of Islets and for beta-Cell Function During Aging.
Title: Trefoil Factor 2 Expressed by the Murine Pancreatic Acinar Cells Is Required for the Development of Islets and for β-Cell Function During Aging.
The Forms of the Lectin Tff2 Differ in the Murine Stomach and Pancreas: Indications for Different Molecular Functions.
Title: The Forms of the Lectin Tff2 Differ in the Murine Stomach and Pancreas: Indications for Different Molecular Functions.
Trefoil factor family 2 inhibits cholangiocarcinogenesis by regulating the PTEN pathway in mice.
Title: Trefoil factor family 2 inhibits cholangiocarcinogenesis by regulating the PTEN pathway in mice.
Trefoil factor 2 secreted from damaged hepatocytes activates hepatic stellate cells to induce fibrogenesis.
Title: Trefoil factor 2 secreted from damaged hepatocytes activates hepatic stellate cells to induce fibrogenesis.
Deoxycholic acid-stimulated macrophage-derived exosomes promote spasmolytic polypeptide-expressing metaplasia in the stomach.
Title: Deoxycholic acid-stimulated macrophage-derived exosomes promote spasmolytic polypeptide-expressing metaplasia in the stomach.
Exocrine tissue-driven TFF2 prevents apoptotic cell death of endocrine lineage during pancreas organogenesis.
Title: Exocrine tissue-driven TFF2 prevents apoptotic cell death of endocrine lineage during pancreas organogenesis.
this work demonstrates that lung macrophages rely upon Trefoil factor 2 to promote epithelial proliferation following damage caused by sterile wounding, Nippostrongylus brasiliensis or Bleomycin sulfate
Title: Macrophages promote epithelial proliferation following infectious and non-infectious lung injury through a Trefoil factor 2-dependent mechanism.
we show a previously unappreciated role for TFF2, produced by either hematopoietic or nonhematopoietic sources, as a pro-proliferative factor for lung epithelial cells under steady-state and infectious injury conditions.
Title: Trefoil Factor 2 Promotes Type 2 Immunity and Lung Repair through Intrinsic Roles in Hematopoietic and Nonhematopoietic Cells.
the Tg(Tff1-CreERT2;Tff2-rtTA;Tff3-Luc) strain can confer intermittent transgene expression to gastric epithelial cells that have undergone previous gene modification, and may be suitable to genetically model therapeutic intervention during development, tumorigenesis, and other genetically tractable diseases
Title: Inducible gene modification in the gastric epithelium of Tff1-CreERT2, Tff2-rtTA, Tff3-luc mice.
Splenic TFF2 is released by vagally modulated memory T cells to suppress expansion of myeloid-derived suppressor cells (MDSC) through CXCR4. TFF2 is important to the anti-inflammatory reflex arc and has an essential role in arresting MDSC proliferation.
Title: Neural innervation stimulates splenic TFF2 to arrest myeloid cell expansion and cancer.

Submit: New GeneRIF Correction See all GeneRIFs (34)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (4) 1 citation

General gene information

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Markers

PMC150833P1 (e-PCR)
- UniSTS:271112

Tff2 (e-PCR), detects polymorphism
- UniSTS:234020

Tff2 (e-PCR), detects polymorphism
- UniSTS:259662

Tff2 (e-PCR), detects polymorphism
- UniSTS:259155

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables CXCR4 chemokine receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables CXCR4 chemokine receptor binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within calcium-mediated signaling	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chemokine-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within chemokine-mediated signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of establishment of localization in cell	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of gastric acid secretion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of macrophage activation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in maintenance of gastrointestinal epithelium	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of gastric acid secretion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of gastric acid secretion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of macrophage activation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of ERK1 and ERK2 cascade	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of cell population proliferation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of cell migration	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: trefoil factor 2

Names: spasmolytic polypeptide

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_009363.3 → NP_033389.2 trefoil factor 2 precursor

Status: PROVISIONAL

Source sequence(s)

AK003093

Consensus CDS

CCDS37545.1

UniProtKB/Swiss-Prot

O08913, Q03404

UniProtKB/TrEMBL

Q9QX97

Related

ENSMUSP00000024826.8, ENSMUST00000024826.8

Conserved Domains (2) summary

smart00018
Location:79 → 124

PD; P or trefoil or TFF domain

pfam00088
Location:36 → 72

Trefoil; Trefoil (P-type) domain